- document
-
van Tienderen, Gilles S. (author), van Beek, M.E.A. (author), Schurink, Ivo J. (author), Rosmark, Oskar (author), Roest, Henk P. (author), Demmers, J.A.A. (author), Muntz, I.A.A. (author), Conboy, J.P. (author), Koenderink, G.H. (author)Cholangiocarcinoma (CCA) is a type of liver cancer with an aggressive phenotype and dismal outcome in patients. The metastasis of CCA cancer cells to distant organs, commonly lung and lymph nodes, drastically reduces overall survival. However, mechanistic insight how CCA invades these metastatic sites is still lacking. This is partly because...journal article 2023
- document
-
van Tienderen, Gilles S. (author), Conboy, J.P. (author), Muntz, I.A.A. (author), Willemse, Jorke (author), Tieleman, Jantine (author), Monfils, Kathryn (author), Schurink, Ivo J. (author), Demmers, J.A.A. (author), Koenderink, G.H. (author)Tumor initiation and progression are critically dependent on interaction of cancer cells with their cellular and extracellular microenvironment. Alterations in the composition, integrity, and mechanical properties of the extracellular matrix (ECM) dictate tumor processes including cell proliferation, migration, and invasion. Also in primary...journal article 2023