Searched for: subject%3A%22microfabrication%22
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Pak, A. (author)
Currently, neurostimulation holds the capability of treating symptoms associated with epilepsy, essential tremor, depression, migraine, incontinence, Parkinson's, Tourette's, and other diseases and disorders. Given the constant evolution in the field of biomedical technology and the increasing demand for advanced solutions in neural interface...
doctoral thesis 2024
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Li, J. (author)
Around 10% of the population will have to go through a catheterization procedure for the treatment of a cardiovascular disease at a certain stage of their lives. During such a procedure, smart catheters will be the "eyes and ears" of the surgeons, significantly improving the diagnosis and treatment. However, there have been very limited...
doctoral thesis 2024
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Carballás Boluda, Ramón (author)
The current drug development process is a costly effort both in terms of budget and time. Organ-on-Chip (OoC) technologies are rapidly developing and are used for various applications and studies that aim to reduce the costs of this process. They represent the convergence between tissue engineering and microfluidic technology to provide...
master thesis 2023
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Puchol Morejón, Eduardo (author)
master thesis 2023
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van Damme, Niels (author)
In the emerging research field of bioelectronic medicine, it has been indicated that neuromodulation of the Vagus Nerve (VN) has the potential to treat various conditions such as epilepsy, depression, and autoimmune diseases. In order to reduce side effects, as well as to increase the effectiveness of the delivered therapy, sub-fascicle...
master thesis 2023
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Woerdman, Hidde (author)
master thesis 2023
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kadel, Himanshu (author)
The brain is the most intricate organ in the human body, yet the underlying mechanisms of its cells and networks are not fully mapped. In addition to this lack of understanding, there are numerous neurological disorders and diseases for which a cure remains elusive. There has been persistent research to understand how neuronal cells function...
master thesis 2023
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Dostanic, M. (author)
The high death toll of cardiovascular diseases worldwide and the lack of effective treatments for them are the main motivation for developing alternative and more efficient models for cardiac drug development and disease research. The missing link between current laboratory research on static in vitro and animal models and the clinical stage...
doctoral thesis 2023
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Dostanic, M. (author), Windt, Laura (author), Wiendels, Maury (author), van Meer, Berend J. (author), Mummery, Christine L. (author), Sarro, Pasqualina M (author), Mastrangeli, Massimo (author)
We present a novel design of elastic micropillars for tissue self-assembly in engineered heart tissue (EHT) platforms. The innovative tapered profile confines reproducibly the tissue position along the main micropillar axis, increasing the accuracy of tissue contraction force measurement. Polydimethylsiloxane-based pillars were designed and...
conference paper 2023
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Burghoorn, Niels (author)
Medical technology has seen great progress over the last centuries, developing increasingly more specialised therapy to benefit human health. The rise of the pharmaceutical industry and the research it drives are contributors to this success. However, in humanity's attempt to tackle more and more complex health issues, the conventional methods...
master thesis 2022
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Karim, Tawab (author)
Treatment of diseases, illnesses or disorders are always sought without any undesired side-effects and complications. Neurological disorders, such as Epilepsy and Parkinson’s, are currently treated using pharmaceuticals. However, drugs have a low specificity and lose their effectiveness after several years. In addition, prolonged drug usage...
master thesis 2022
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Schoonhoven, Jilian (author)
The current standard for organ-on-chip substrate materials is polydimethylsiloxane (PDMS). PDMS has many beneficial properties such as biocompatibility, transparency, elasticity, and easy prototyping. The main disadvantages of PDMS are its hydrophobicity (reducing cell attachment and cell proliferation), quick hydrophobic recovery (within a few...
master thesis 2022
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Kasi, D.G. (author), de Graaf, M.N.S. (author), Motreuil-Ragot, P.A. (author), Frimat, Jean-Phillipe M. S. (author), Ferrari, Michel D. (author), Sarro, Pasqualina M (author), Mastrangeli, Massimo (author), van den Maagdenberg, Arn M.J.M. (author), Mummery, Christine (author), Orlova, Valeria (author)
Organ-on-a-chip (OoC) and microfluidic devices are conventionally produced using microfabrication procedures that require cleanrooms, silicon wafers, and photomasks. The prototyping stage often requires multiple iterations of design steps. A simplified prototyping process could therefore offer major advantages. Here, we describe a rapid and...
journal article 2022
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Revyn, N. (author), Hu, Michel H.Y. (author), Frimat, Jean-Philippe (author), de Wagenaar, B. (author), van den Maagdenberg, Arn M.J.M. (author), Sarro, Pasqualina M (author), Mastrangeli, Massimo (author)
We present preliminary recordings on chip of three-dimensional (3D) electric neuronal activity from cultures of cortical neurons derived from human-induced pluripotent stem cells (hiPSCs). The recordings were obtained through 3D microelectrode arrays (MEAs) composed of truncated, 90 μm-high Si micropyramids endowed with multiple, electrically...
conference paper 2022
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Roy, Kaustav (author), Shastri, V.U. (author), Kumar, Akshay (author), Rout, Jagi (author), Isha, Isha (author), Kalyan, Kritank (author), Prakash, Jaya (author), Pratap, Rudra (author)
We report on the development of a novel piezo-MEMS-based optofluidic platform to detect the concentration of various species dissolved in a fluid. This platform employs piezoelectric micromachined ultrasound transducers (PMUTs) to work as a photoacoustic receiver, receiving ultrasound from fluid targets present in microfluidic channels while...
conference paper 2022
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Li, J. (author), Li, Chenhui (author), Henneken, Vincent (author), Louwerse, Marcus (author), Van Rens, Jeannet (author), Dijkstra, Paul (author), Raz, Oded (author), Dekker, R. (author)
The digitization of smart catheters will dramatically increase the demand for reliable and high data transmission in the distal tips. Optical fiber is a good candidate to provide high-speed data transmission. However, the extremely small size of the smart catheter tip, with less than a few millimeters in diameter, hampers the integration of...
journal article 2022
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Castillo Ransanz, Lucía (author), van Altena, P.F.J. (author), Heine, Vivi M. (author), Accardo, A. (author)
The biomechanical properties of the brain microenvironment, which is composed of different neural cell types, the extracellular matrix, and blood vessels, are critical for normal brain development and neural functioning. Stiffness, viscoelasticity and spatial organization of brain tissue modulate proliferation, migration, differentiation, and...
review 2022
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Krishnaswamy, Medha (author)
Optogenetics is a neuromodulation technique that uses light to control genetically modified cells to express light sensitive ion channels. Optogenetics allows stimulation of only the specific cells in the region that have been genetically modified and thus results in a high resolution of stimulation.<br/>Currently optogenetic implants are used...
master thesis 2021
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Ivančević, Lovro (author)
The lack of reliable human physiology models in vitro combined with an ever-increasing set of health and safety requirements imposed by pharmaceutical regulatory agencies across the world is causing a concerningly low number of new drugs to reach the market. Organ-on-Chip (OoC) technology aims to aid faster development of new drugs by providing...
master thesis 2021
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Spinatelli, Vieri (author)
The on-field performance and lifespan of PV modules are affected by the interaction of numerous parameters, among which temperature, strain, and humidity. Among these parameters, only temperature is occasionally measured in PV installations, and such monitoring is often external to the module. This limits its use and does not provide accurate...
master thesis 2021
Searched for: subject%3A%22microfabrication%22
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