Searched for: subject:"microfabrication"
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Galiti, Danai (author)
Currently, preclinical drug testing and disease modelling are based on static cell cultures and animal models that often fail at predicting the human pathophysiology. Alternatively, Organ-on-Chips (OoCs), dynamic microphysiological platforms, can be employed to recapitulate organ functions and mimic the cell's microphysiological environment....
master thesis 2021
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Dostanic, M. (author), Stein, Jeroen (author), Windt, Laura (author), van Meer, Berend (author), Bellin, Milena (author), Orlova, Valeria (author), Mastrangeli, M. (author), Mummery, Christine (author), Sarro, P.M. (author)
We present a wafer-scale fabricated, PDMS-based platform for culturing miniaturized engineered heart tissues (EHTs) which allows highly accurate measurements of the contractile properties of these tissues. The design of the platform is an anisometrically downscaled version of the Heart-Dyno system, consisting of two elastic micropillars inside...
journal article 2020
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Demirci, Eda (author)
[Background] This project provides a proof of principle to use microneedles in combination with optical spectroscopy for bilirubin detection. For newborns, high bilirubin levels in the blood can lead to serious health consequences, such as jaundice, which can lead to brain damage. Therefore, it should be detected as early as possible. However,...
master thesis 2019
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Naaborg, Jeroen (author)
The Flex-to-Rigid (F2R) technology platform is an interconnect platform to integrate heterogeneous electronic systems and devices onto a partially flexible chip for minimally invasive medical instruments. This technology platform allows for the integration of micro electro-mechanical systems (MEMS) and integrated circuits (IC) on a chip in a...
master thesis 2019
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Mytnyk, S. (author)
Growing importance of hydrogels in various areas of human life has led to increasing need in controlling their properties, which is generally achieved by adjusting hydrogels shape and microstructure. Even though standard microfabrication and microstructuring techniques can be currently applied in hydrogel research, the variety of properties of...
doctoral thesis 2019
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Lambert, Pierre (author), Mastrangeli, M. (author)
contribution to periodical 2019
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Hol, F.J.H. (author), Whitesides, George M. (author), Dekker, C. (author)
Habitat spatial structure has a profound influence on bacterial life, yet there currently are no low-cost equipment-free laboratory techniques to reproduce the intricate structure of natural bacterial habitats. Here, we demonstrate the use of paper scaffolds to create landscapes spatially structured at the scales relevant to bacterial ecology...
journal article 2019
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Huang, Chengyu (author)
Optogenetics is a biological technique that uses light to control cells in living tissues, typically neurons, that have been genetically modified to express light-sensitive ion channels. Using this technique, neuroscientists can investigate the neural circuits underlying neurological diseases with a higher spatio-temporal resolution when...
master thesis 2018
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Joshi, S. (author)
Advancements in stretchable electronic systems have changed the way modern electronics interact with their target systems, by their conformability to more complex shapes as compared to conventional rigid or flexible electronics. By utilizing this, limitless applications in the field of healthcare can be realized, such as wearable and implantable...
doctoral thesis 2018
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Aher, Amol (author), Kok, M.W.A. (author), Sharma, Ashwani (author), Rai, Ankit (author), Olieric, Natacha (author), Rodriguez-Garcia, Ruddi (author), Katrukha, Eugene A. (author), Weinert, Tobias (author), Olieric, Vincent (author), Kapitein, Lukas C. (author), Steinmetz, Michel O. (author), Dogterom, A.M. (author), Akhmanova, Anna (author)
The dynamic instability of microtubules plays a key role in controlling their organization and function, but the cellular mechanisms regulating this process are poorly understood. Here, we show that cytoplasmic linker-associated proteins (CLASPs) suppress transitions from microtubule growth to shortening, termed catastrophes, including those...
journal article 2018
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van Assenbergh, S.P. (author), Meinders, Erwin (author), Geraedts, Jo M.P. (author), Dodou, D. (author)
When designing a new nanostructure or microstructure, one can follow a processing-based manufacturing pathway, in which the structure properties are defined based on the processing capabilities of the fabrication method at hand. Alternatively, a performance-based pathway can be followed, where the envisioned performance is first defined, and...
review 2018
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Zhang, S. (author), Zeng, X. (author), Igartua, A. (author), Rodriguez-Vidal, E. (author), van der Heide, E. (author)
Surface texture is important for contact mechanical and tribological phenomena such as the contact area and friction. In this research, three different types of geometrical microstructures were designed and fabricated by pulsed laser surface texturing as semi-symmetric (grooved channel), asymmetric fractal (Hilbert curve), and symmetric...
journal article 2017
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Silvestri, C. (author)
The performances of microelectronic and optoelectronic devices are often severely limited by high temperatures and insufficient heat management. Therefore, when considering device fabrication and packaging, it is important to select materials based on their thermal performance. The increasing demand for more integrated functionality and...
doctoral thesis 2017
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Gritti, N. (author)
doctoral thesis 2017
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Dahar, S. (author)
This thesis presents a fabrication process for medical microfluidic devices that is performed with purely silicon microfabrication methods, which is a better option for mass-production than commonly used soft lithography. The fluids passing through the channels of a microfluidic device that is fabricated using this developed method can be...
master thesis 2016
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Zhang, S. (author), Zeng, X. (author), Matthews, D. T A (author), Igartua, A. (author), Rodriguez-Vidal, E. (author), Contreras Fortes, J. (author), Saenz de Viteri, V. (author), Pagano, F. (author), Wadman, B. (author), Wiklund, E. D. (author), van der Heide, E. (author)
This review gives a concise introduction to the state-of-art techniques used for surface texturing, e.g., wet etching, plasma etching, laser surface texturing (LST), 3D printing, etc. In order to fabricate deterministic textures with the desired geometric structures and scales, the innovative texturing technologies are developed and extended....
journal article 2016
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Stoute, R. (author), Louwerse, M.C. (author), Henneken, VA (author), Dekker, R. (author)
Minimally invasive surgery of the most lethal disease worldwide, coronary artery disease, benefits from better diagnostic tools during the treatment. With this in mind, a novel concept is introduced for intravascular ultrasound on a 360 μm diameter guidewire. The complex manufacture of this medical instrument, and other devices that require...
journal article 2016
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Moolman, M.C. (author)
Investigating DNA replication in live E. coli cells using fluorescence microscopy and microfluidics.
doctoral thesis 2015
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Ma, X (author), Kato, Y (author), van Kempen, F.C.M. (author), Hirai, Y (author), Tsuchiya, T (author), van Keulen, A. (author), Tabata, O (author)
We report a multiple patterning approach utilizing digital-micromirror-device (DMD)-based grayscale lithography, providing a solution to improve fabrication accuracy for entire target three-dimensional structure. Because DMD-based lithography system consists a projection lens system, better resolution can be obtained around focal position...
conference paper 2015
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Hol, F.J.H. (author)
In this thesis, I describe experiments aimed at understanding bacterial population dynamics in ecosystems that are spatially structured at the micro-scale. We combine microfabrication and microfluidics to create synthetic ecosystems that have a complex yet well-defined geometry and chemical composition. Bacteria that inhabit such ecosystems can...
doctoral thesis 2014
Searched for: subject:"microfabrication"
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