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Braem, Sarah (author)Drug efficacy and side effects are significantly impacted by the first-pass metabolism, a sequence of events that occurs in the stomach and the liver after oral ingestion. Accurate prediction of this mechanism is crucial for a faster and more cost-efficient drug development process. Replicating the first-pass metabolism in vitro using standard...master thesis 2023
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Blöbaum, Luisa (author), Haringa, C. (author), Grünberger, Alexander (author)Bioprocesses are scaled up for the production of large product quantities. With larger fermenter volumes, mixing becomes increasingly inefficient and environmental gradients get more prominent than in smaller scales. Environmental gradients have an impact on the microorganism's metabolism, which makes the prediction of large-scale performance...review 2023
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Nagalingam, Nagaraj (author), Raghunathan, Aswin (author), Korede, V.B. (author), Overmars, E.F.J. (author), Hung, S. (author), Hartkamp, R.M. (author), Padding, J.T. (author), Smith, C.S. (author), Eral, H.B. (author)Optofluidic devices have revolutionized the manipulation and transportation of fluid at smaller length scales ranging from micrometers to millimeters. We describe a dedicated optical setup for studying laser-induced cavitation inside a microchannel. In a typical experiment, we use a tightly focused laser beam to locally evaporate the solution...journal article 2023
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Trapp, S. (author), Lammers, Tom (author), Engudar, Gokce (author), Hoehr, Cornelia (author), Denkova, A.G. (author), Paulssen, E. (author), de Kruijff, R.M. (author)Background: The radionuclide Ga-68 is commonly used in nuclear medicine, specifically in positron emission tomography (PET). Recently, the interest in producing Ga-68 by cyclotron irradiation of [<sup>68</sup>Zn]Zn nitrate liquid targets is increasing. However, current purification methods of Ga-68 from the target solution consist of multi...journal article 2023
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Muralidharan, A. (author)Delivery of biomolecules using pulsed electric fields or electrotransfer has applications such as biomedical engineering, bioprocess engineering and genomic engineering. When a cell is placed in an electric field, the induced transmembrane voltage catalyzes the formation of pores on the cell membrane. This enables the delivery of otherwise cell...doctoral thesis 2022
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Angenent, Maricke (author)Cardiorenal Syndrome (CRS) is a multi-organ disease characterized by a reciprocal pathological interaction between the heart and kidneys during acute or chronic injury. Yet, a complete understanding of the underlying bi-directional pathophysiological mechanisms is lacking, hence obscuring effective diagnostic strategies, patient stratification...master thesis 2022
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Tsan, Vi-hung (author)Acoustic Force Spectroscopy (AFS) is a versatile tool that uses sound waves to manipulate tiny particles such as cells, bacteria, and even zebrafish embryos in microfluidic systems. This kind of acoustic tweezer is gaining increasing attention due to its high throughput capability and non-invasiveness. In addition, this device allows for...master thesis 2022
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Bekkema, Bart (author)Radiometals re-emerge as a promising alternative in nuclear imaging. Cyclotron production of such radiometals using liquid targets solve critical impurity problems seen with current conventional production methods. Purification employing liquid-liquid extraction in microfluidic environments has recently been investigated. Fluid behaviour in...master thesis 2022
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Raghunathan, Aswin (author)Crystallization is one of the most sought after separation and purification technique in the process industries. However, the fundamental understanding on the formation of crystals poses quite a challenge due to the inherent complexity and stochasticity associated with the process. In the past, several attempts put forth to control crystal...master thesis 2022
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Kislaya, A. (author)The precise manipulation of particles and droplets is crucial to many microfluidic applications in engineering. The design of microfluidic devices is generally tailored to perform a specific task, with each specific application requiring a unique and fixed design. In this way, using a single device to perform multiple analyses of a wide range of...doctoral thesis 2022
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Blankespoor, Maarten (author)The processes that take place within cells are complex. Single-cell analysis is a method that is employed to gain further understanding of the working mechanisms on a single-cellular level. The controlled transport of substances through the cell membrane is important for studying the behaviour and responses of single living cells. Femtopipettes...master thesis 2022
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- Liu, Z. (author) doctoral thesis 2022
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Bieling, Thijs (author)Evaporation can induce acoustic emissions in microfluidic devices. The origin of these emissions and their damping remains elusive. This thesis studies acoustic emissions from 3D printed microfluidic tubes mimicking xylem vessels in plants. We show the time and frequency domain signature of these emissions. From these signatures, we identify...master thesis 2022
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de Jong, Rémy (author)Microfluidic extraction is a promising alternative for existing extraction methods of radioisotopes due to the high surface-to-volume ratio. When assessing the compatibility of microfluidic material with the extraction system, there are three critical aspects—compatibility with organic solvents, compatibility with the radiochemistry, and, most...master thesis 2022
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Yeh, Jia-Jun (author)Particle sorting is an important step in many biological and biomedical techniques. One sorting technique that has received a lot of attention is based on acoustophoresis. Manipulating cells with acoustic forces allows for a sorting method based on physical properties in a non-invasive, label-free, and biocompatible manner. To date, acoustic...master thesis 2022
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Aghaseyedi, Maryam (author), Salehi, Alireza (author), Valijam, Shayan (author), Shooshtari, M. (author)A microfluidic-based gas sensor was chosen as an alternative method to gas chromatography and mass spectroscopy systems because of its small size, high accuracy, low cost, etc. Generally, there are some parameters, such as microchannel geometry, that affect the gas response and selectivity of the microfluidic-based gas sensors. In this study, we...journal article 2022
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van Rooijen, W.A. (author), Hashemi, L. (author), Boon, M.M. (author), Farajzadeh, R. (author), Hajibeygi, H. (author)Underground Hydrogen Storage (UHS) is an attractive technology for large-scale (TWh) renewable energy storage. To ensure the safety and efficiency of the UHS, it is crucial to quantify the H<sub>2</sub> interactions with the reservoir fluids and rocks across scales, including the micro scale. This paper reports the experimental measurements...journal article 2022
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Roy, Kaustav (author), Shastri, V.U. (author), Kumar, Akshay (author), Rout, Jagi (author), Isha, Isha (author), Kalyan, Kritank (author), Prakash, Jaya (author), Pratap, Rudra (author)We report on the development of a novel piezo-MEMS-based optofluidic platform to detect the concentration of various species dissolved in a fluid. This platform employs piezoelectric micromachined ultrasound transducers (PMUTs) to work as a photoacoustic receiver, receiving ultrasound from fluid targets present in microfluidic channels while...conference paper 2022
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van Putten, R. (author), Eyke, Natalie S. (author), Baumgartner, L.M. (author), Schultz, Victor L. (author), Filonenko, G.A. (author), Jensen, Klavs F. (author), Pidko, E.A. (author)Automation and microfluidic tools potentially enable efficient, fast, and focused reaction development of complex chemistries, while minimizing resource- and material consumption. The introduction of automation-assisted workflows will contribute to the more sustainable development and scale-up of new and improved catalytic technologies....journal article 2022
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Mehta, P.P. (author), Rahman, Z. (author), ten Dijke, Peter (author), Boukany, P. (author)An early step of metastasis requires a complex and coordinated migration of invasive tumor cells into the surrounding tumor microenvironment (TME), which contains extracellular matrix (ECM). It is being appreciated that 3D matrix-based microfluidic models have an advantage over conventional in vitro and animal models to study tumor...review 2022