- document
-
Mastrangeli, Massimo (author), Millet, Sylvie (author), ORCHID partners, the (author), van den Eijnden-van Raaij, Janny (author)Organ-on-Chip is considered a potentially game-changing technology born from the convergence of tissue engineering and microfluidic technology. Organ-on-Chip devices (OoCs) are expected to offer effective solutions to persisting problems in drug development and personalized disease treatments. This opinion paper surveys the current landscape in...journal article 2019
- document
-
Nagalingam, Nagaraj (author)The recent advancements in lab-on-a-chip technologies has led to numerous studies on the collective dynamics of micro-particles suspended in a microfluidic channel. The role of hydrodynamics in “self-steering” of the particles in a low Reynolds flows is explicitly dependent only on the particle’s exterior geometry. Thus richer responses can be...master thesis 2019
- document
-
Sudha, Anand (author)Considering the abundance of viscoelastic fluids in nature, growing attention has been received for the study of microorganisms in viscoelastic fluids. In Newtonian fluids, the flow of microorganisms is governed by the viscosity alone. But in viscoelastic fluids, the addition of the elastic component complicates the situation. The flow of the...master thesis 2019
- document
-
Stortelder, Roel (author)Analyzing the different signaling pathways of cells is key in understanding the basic functions of the cells in all organic systems from algae to humans. Not only do they help solve our questions on how organisms function, they also allow for new cures to be explored. A large variety of these signaling pathways can be influenced by light and can...master thesis 2019
- document
-
Mytnyk, S. (author)Growing importance of hydrogels in various areas of human life has led to increasing need in controlling their properties, which is generally achieved by adjusting hydrogels shape and microstructure. Even though standard microfabrication and microstructuring techniques can be currently applied in hydrogel research, the variety of properties of...doctoral thesis 2019
- document
-
Nouri Goushki, M. (author), Sharma, Abhishek (author), Sasso, L. (author), Zhang, Shuang (author), van der Eerden, B.C.J. (author), Staufer, U. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Manufacturing high throughput in vitro models resembling the tissue microenvironment is highly demanded for studying bone regeneration. Tissues such as bone have complex multiscale architectures inside which cells reside. To this end, engineering a microfluidic platform incorporated with three-dimensional (3D) microscaffolds and submicron...journal article 2019
- document
-
Liu, Q. (author), Zhao, M. (author), Mytnyk, S. (author), Klemm, B. (author), Zhang, K. (author), Wang, Y. (author), Yan, Dadong (author), Mendes, E. (author), van Esch, J.H. (author)Hydrogel microparticles are important in materials engineering, but their applications remain limited owing to the difficulties associated with their manipulation. Herein, we report the self-orientation of crescent-shaped hydrogel microparticles and elucidate its mechanism. Additionally, the microparticles were used, for the first time, as...journal article 2019
- document
-
Kumar, P. (author), Fanzio, P. (author), Sasso, L. (author), Langelaar, Matthijs (author)The concept and synthesis approach for planar Compliant Fluidic Control Structures (CFCSs), monolithic flexible continua with embedded functional pores, is presented in this manuscript. Such structures are envisioned to find application in biomedicine as tunable microfluidic devices for drug/nutrient delivery. The functional pores enlarge and...journal article 2019
- document
-
Fanalista, F. (author), Birnie, A.T.F. (author), Maan, R. (author), Burla, Federica (author), Charles usagé Charles-Carty, K.V. (author), Pawlik, G. (author), Deshpande, S.R. (author), Koenderink, Gijsje H. (author), Dogterom, A.M. (author), Dekker, C. (author)Bottom-up biology is an expanding research field that aims to understand the mechanisms underlying biological processes via in vitro assembly of their essential components in synthetic cells. As encapsulation and controlled manipulation of these elements is a crucial step in the recreation of such cell-like objects, microfluidics is...journal article 2019
- document
-
Schaich, Michael (author), Cama, Jehangir (author), Al Nahas, Kareem (author), Sobota, Diana (author), Sleath, Hannah (author), Jahnke, Kevin (author), Deshpande, S.R. (author), Dekker, C. (author), Keyser, Ulrich F. (author)The low membrane permeability of candidate drug molecules is a major challenge in drug development, and insufficient permeability is one reason for the failure of antibiotic treatment against bacteria. Quantifying drug transport across specific pathways in living systems is challenging because one typically lacks knowledge of the exact...journal article 2019
- document
-
Hubbe, H.M.K. (author), Mendes, E. (author), Boukany, P. (author)Polymer nanowire-related research has shown considerable progress over the last decade. The wide variety of materials and the multitude of well-established chemical modifications have made polymer nanowires interesting as a functional part of a diagnostic biosensing device. This review provides an overview of relevant publications addressing...review 2019
- document
-
Deshpande, S.R. (author), Wunnava Venkata, S.S. (author), Hueting, D.A. (author), Dekker, C. (author)Recent years have seen a tremendous interest in the bottom-up reconstitution of minimal biomolecular systems, with the ultimate aim of creating an autonomous synthetic cell. One of the universal features of living systems is cell growth, where the cell membrane expands through the incorporation of newly synthesized lipid molecules. Here, the...journal article 2019
- document
-
Alston, Mark E. (author), Pottgiesser, U. (author), Knaack, U. (author)The glazed envelopes on buildings play a major role in operational energy consumption as they define the boundary conditions between climate and thermal comfort. Such a façade is viewed as an uncontrolled load that sets the operational performance requirements for artificial lighting and air-cooling mechanical systems. This is in contrast to...journal article 2019
- document
-
Bui, T.H. (author)The thesis focuses on the investigation of thin-film surface acoustic wave (SAW) devices for liquid sensing applications. The piezoelectric material is a thin film of Aluminum Nitride (AlN), a CMOS compatible material, deposited by pulse DC reactive sputtering technique. A CMOS compatible process is developed and employed to fabricate the AlN/Si...doctoral thesis 2018
- document
-
Tio, Kimberly (author)Administration of drugs can help in the recovery of the brain for example after a stroke. There are many available delivery routes such as intravenous injection or local injection in the brain. Whereas, the former encounters problems with systemic side effects, the latter requires multiple invasive brain surgery. Local drug administration could...master thesis 2018
- document
-
Kramer, Robert (author)Suspended hollow micro-cantilevers have been employed for zeptogram (10^-21 g) mass measurements, pipetting of femtoliter<br/>(10^-15 L) volumes, and studies on mechanical interaction with single cells. The main fabrication method of these devices is by standard clean room micro/nano fabrication techniques, however, they are inherently planar,...master thesis 2018
- document
-
Developing a microfluidic device incorporating submicron topographies for studying bone regenerationSharma, Abhishek (author)A major challenge facing the study of bone regeneration today is the inability to mimic the tissue microenvironment and the factors comprising it. Organ-on-chip based microfluidic systems today aim at doing so by dynamically culturing living cells in them. These are preferred owing to their small feature sizes, laminar flows, high throughput,...master thesis 2018
- document
-
D Souza, Savio (author)Micro and Nano-mechanical resonators are becoming increasingly ubiquitous in the areas of particle characterization and biological sensing. For biological sensing, however, the presence of a liquid environment is a pre-requisite. Hollow cantilevers, which allow fluids to be transported inside the resonator, often have high quality factors even...master thesis 2018
- document
-
Soons, Sophie (author)To control fluid transport, microfluidic systems often make use of pressure driven flow and pneumatically actuated valves. However these require bulky external instrumentation. An integrated fluid control mechanism would make microfluidic systems more portable, closed and automated. The aim of this project was to create a pH-responsive membrane...master thesis 2018
- document
-
Looman, Miranda (author)Organ on a Chip (OoC) systems are of high interest through its use for medicine testing in a small time scale without the need for animal testing. Membranes used in OoCs form a base to grow cells on and need to be suitable for cell-attachment and porous. Fouling is the 'Achilles heel' in membrane performance. Research shows that as a result of...master thesis 2018