Searched for: subject%3A%22microscopy%22
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Wiersma, M.S.J. (author), Heiles, B.G. (author), Kalisvaart, D. (author), Maresca, D. (author), Smith, C.S. (author)
Ultrasound localization microscopy (ULM) is a vascular imaging method that provides a 10-fold improvement in resolution compared to ultrasound Doppler imaging. Because typical ULM acquisitions accumulate large numbers of synthetic microbubble (MB) trajectories over hundreds of cardiac cycles, transient hemodynamic variations such as pulsatility...
journal article 2022
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Giasin, Khaled (author), Atif, Muhammad (author), Ma, Yuan (author), Jiang, Chulin (author), Koklu, Ugur (author), Sinke, J. (author)
GLARE laminates are multi-layered metal-composite materials created from bonding sheets of metallic alloys with carbon or glass fibre layers. The application of hybrid-conventional machining processes such as ultrasonic-assisted drilling (UAD) is becoming of great interest to the aerospace industry due to its capability in reducing the...
journal article 2022
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Mahmoudabadi, Parvin (author), Tavakoli-Kakhki, Mahsan (author), Hassan HosseinNia, S. (author)
Accurate representation of the atomic force microscopy (AFM) system is not only necessary to achieve control objectives, but it is also beneficial for detecting the nanomechanical properties of the samples. To this end, this paper addresses the issue of controller design for the AFM system based on an accurate nonaffine nonlinear distributed...
journal article 2022
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Marques Pereira, V. (author), Davis, T. P. (author), Mayoral, M. H. (author), Kumar, A. (author), Schut, H. (author), Sietsma, J. (author)
Oxide Dispersion Strengthened (ODS) steels are potential candidate materials for application as structural components of fission and fusion reactors, known for their high thermal stability, high resistance to creep and to radiation-induced damage. These attractive properties result from the presence of the fine and highly thermally stable...
journal article 2022
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Lane, R. (author), Wolters, Anouk H.G. (author), Giepmans, Ben N.G. (author), Hoogenboom, J.P. (author)
Volume electron microscopy (EM) of biological systems has grown exponentially in recent years due to innovative large-scale imaging approaches. As a standalone imaging method, however, large-scale EM typically has two major limitations: slow rates of acquisition and the difficulty to provide targeted biological information. We developed a 3D...
journal article 2022
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Eren, E. Deniz (author), Nijhuis, Wouter H. (author), van der Weel, Freek (author), Dede Eren, Aysegul (author), Ansari, Sana (author), Bomans, Paul H.H. (author), Friedrich, Heiner (author), Sakkers, Ralph J. (author), Weinans, Harrie (author), de With, Gijsbertus (author)
Bone is a complex natural material with a complex hierarchical multiscale organization, crucial to perform its functions. Ultrastructural analysis of bone is crucial for our understanding of cell to cell communication, the healthy or pathological composition of bone tissue, and its three-dimensional (3D) organization. A variety of techniques...
journal article 2022
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Noom, J. (author), Soloviev, O.A. (author), Smith, C.S. (author), Nguyen, Hieu Thao (author), Verhaegen, M.H.G. (author)
We demonstrate a novel closed-loop input design technique on the detection of particles in an imaging system such as a fluorescence microscope. The probability of misdiagnosis is minimized while constraining the input energy such that for instance phototoxicity is reduced. The key novelty of the closed-loop design is that each next input is...
conference paper 2022
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McKenzie, R. (author), Keizer, Emma M. (author), Vink, J.N.A. (author), van Lopik, Jasper (author), Büke, F. (author), Kalkman, Vera (author), Fleck, Christian (author), Tans, S.J. (author), Brouns, S.J.J. (author)
While CRISPR-Cas defence mechanisms have been studied on a population level, their temporal dynamics and variability in individual cells have remained unknown. Using a microfluidic device, time-lapse microscopy and mathematical modelling, we studied invader clearance in Escherichia coli across multiple generations. We observed that CRISPR...
journal article 2022
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Meng, X. (author), Huismans, Lex (author), Huijben, T.A.P.M. (author), Szabó, G.V. (author), van Tol, R.F.C. (author), De Heer, Izak (author), Ganapathy, S. (author), Brinks, D. (author)
Voltage imaging and optogenetics offer new routes to optically detect and influence neural dynamics. Optimized hardware is necessary to make the most of these new techniques. Here we present the Octoscope, a versatile, multimodal device for all-optical electrophysiology. We illustrate its concept and design and demonstrate its capability to...
journal article 2022
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Büke, F. (author), Grilli, Jacopo (author), Cosentino Lagomarsino, Marco (author), Bokinsky, G.E. (author), Tans, S.J. (author)
Growth and division are central to cell size. Bacteria achieve size homeostasis by dividing when growth has added a constant size since birth, termed the adder principle, by unknown mechanisms.<sup>1</sup><sup>,</sup><sup>2</sup> Growth is well known to be regulated by guanosine tetraphosphate (ppGpp), which controls diverse processes from...
journal article 2022
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Chardon, Florian (author), Japaridze, A. (author), Witt, Hannes (author), Velikovsky, Leonid (author), Chakraborty, Camellia (author), Wilhelm, Therese (author), Dumont, Marie (author), Yang, W.W.W. (author), Dekker, C. (author)
Chromosome inheritance depends on centromeres, epigenetically specified regions of chromosomes. While conventional human centromeres are known to be built of long tandem DNA repeats, much of their architecture remains unknown. Using single-molecule techniques such as AFM, nanopores, and optical tweezers, we find that human centromeric DNA...
journal article 2022
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Rejali, R. (author), Farinacci, L.S.M. (author), Coffey Blanco, D. (author), Broekhoven, R. (author), Gobeil, J. (author), Blanter, Y.M. (author), Otte, A. F. (author)
Atomically engineered artificial lattices are a useful tool for simulating complex quantum phenomena, but have so far been limited to the study of Hamiltonians where electron-electron interactions do not play a role. However, it is precisely the regime in which these interactions do matter where computational times lend simulations a critical...
journal article 2022
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Quesson, B. A.J. (author), van Neer, P.L.M.J. (author), Tamer, M. S. (author), Hatakeyama, K. (author), Van Es, M. H. (author), van Riel, M.C.A. (author), Piras, D. (author)
The semiconductor industry needs to fit ever more devices per unit area to improve their performance; hence a trend towards increasingly complex structures by varying material combinations and 3D geometries with increasing aspect ratios. The new materials used may be optically opaque, posing problems for traditional optical metrology methods....
journal article 2022
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Faraj, Noura (author), Duinkerken, B. H.Peter (author), Carroll, E.C.M. (author), Giepmans, Ben N.G. (author)
Microscopic analysis of molecules and physiology in living cells and systems is a powerful tool in life sciences. While in vivo subcellular microscopic analysis of healthy and diseased human organs remains impossible, zebrafish larvae allow studying pathophysiology of many organs using in vivo microscopy. Here, we review the potential of the...
review 2022
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Angeloni, L. (author), Popa, Bogdan (author), Nouri Goushki, M. (author), Minneboo, M.B. (author), Zadpoor, A.A. (author), Ghatkesar, M.K. (author), Fratila-Apachitei, E.L. (author)
Physical patterns represent potential surface cues for promoting osteogenic differentiation of stem cells and improving osseointegration of orthopedic implants. Understanding the early cell–surface interactions and their effects on late cellular functions is essential for a rational design of such topographies, yet still elusive. In this work...
journal article 2022
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Farinacci, L.S.M. (author), Veldman, L.M. (author), Willke, Philip (author), Otte, A. F. (author)
Historically, electron spin resonance (ESR) has provided excellent insight into the electronic, magnetic, and chemical structure of samples hosting spin centers. In particular, the hyperfine interaction between the electron and the nuclear spins yields valuable structural information about these centers. In recent years, the combination of...
journal article 2022
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Koelling, Sebastian (author), Stehouwer, L.E.A. (author), Paquelet Wuetz, B. (author), Scappucci, G. (author), Moutanabbir, Oussama (author)
Atom probes generate three-dimensional atomic-scale tomographies of material volumes corresponding to the size of modern-day solid-state devices. Here, the capabilities of atom probe tomography are evaluated to analyze buried interfaces in semiconductor heterostructures relevant for electronic and quantum devices. Employing brute-force search...
journal article 2022
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Legerstee, Karin (author), Sueters, J. (author), Abraham, Tsion E. (author), Slotman, Johan A. (author), Kremers, Gert Jan (author), Hoogenboom, J.P. (author), Houtsmuller, A.B. (author)
Focal adhesions (FAs) are the main cellular structures to link the intracellular cytoskeleton to the extracellular matrix. FAs mediate cell adhesion, are important for cell migration and are involved in many (patho)-physiological processes. Here we examined FAs and their associated actin fibres using correlative fluorescence and scanning...
journal article 2022
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Inamdar, A.S. (author), Gromala, Przemyslaw Jakub (author), Prisacaru, Alexandru (author), Kabakchiev, Alexander (author), Yang, Yu Hsiang (author), Han, Bongtae (author)
Epoxy molding compound (EMC) is widely used for encapsulating automotive electronics. Among all of the components of an electronic package, EMC is most exposed to the atmosphere, and thus undergoes aging. During high-temperature operation, EMC is oxidized, which alters its mechanical properties, and thus can affect the reliability of electronic...
book chapter 2022
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Hulleman, C.N. (author)
<i>Localization microscopy has circumvented the diffraction limit by sequentially</i> imaging individual light emitting molecules at a time. The position of these individual molecules can be determined and a super-resolution reconstruction is made with improved resolution. Normally freely rotating emitters are used such that the point spread...
doctoral thesis 2021
Searched for: subject%3A%22microscopy%22
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