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Van Dorp, W.F. (author)
Work started with a critical review of literature from the past 70-odd years. The review shows that the physical processes occurring in EBID are generally well understood. By combining models for electron scattering in a solid and electron beam induced heating and knowledge of growth regimes, the majority of the experimental results was...
doctoral thesis 2008
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Liv, N. (author)
A combined use of fluorescence and light microscopy is a powerful approach to further increase our understanding in biological systems of structure-function relations at cellular and sub-cellular levels. The power of fluorescence microscopy (FM) is to spectrally resolve and visualize individual proteins with endogenous or immuno- fluorescent...
doctoral thesis 2014
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Kuiper, S. (author)
This research is focused on improving the mechatronic design and control strategies of Atomic Force Microscopes (AFM) in order to increase the imaging speed of these instruments, while maintaining the resolution and accuracy of AFM. Different techniques are developed which have led to a faster lateral scanning speed, higher bandwidth control of...
doctoral thesis 2012
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Netten, H. (author)
doctoral thesis 1997
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Yoo, H.W. (author)
Confocal laser scanning microscopy (CLSM) is considered as one of the major advancements in microscopy in the last century and is widely accepted as a 3D fluorescence imaging tool for biological studies. For the emerging biological questions CLSM requires fast imaging to detect rapid biological processes and aberration-corrected imaging to...
doctoral thesis 2015
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Zhao, Q. (author)
Fluorescence microscopy is a well-established platform for biology and biomedical research (Chapter 2). Based on this platform, fluorescence lifetime imaging microscopy (FLIM) has been developed to measure fluorescence lifetimes, which are independent of fluorophore concentration and excitation intensity and offer more information about the...
doctoral thesis 2014
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Janssen, J.W. (author)
Carbon nanotubes are small cylindrical molecules with a typical diameter of 1 nm and lengths of up to micrometers. These intriguing molecules exhibit, depending on the exact atomic structure, either semiconducting or metallic behavior. This makes them ideal candidates for possible future molecular electronics. In this thesis Janssen describes...
doctoral thesis 2001
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Maduro, L.A. (author)
The family of transitionmetal dichalcogenides offer a unique platformfor electronic and optical tunability due to the sensitivity to their dimensional configuration, edge terminations, and varying crystal phases. In this thesis we focus on structures based on the transition metal dichalcogenides MoS2 and WS2. We study how different crystal...
doctoral thesis 2021
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Hulleman, C.N. (author)
<i>Localization microscopy has circumvented the diffraction limit by sequentially</i> imaging individual light emitting molecules at a time. The position of these individual molecules can be determined and a super-resolution reconstruction is made with improved resolution. Normally freely rotating emitters are used such that the point spread...
doctoral thesis 2021
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Kabiri, Y. (author)
The low contrast of biomolecules in TEM has been a great obstacle for their structure determination and hence to the understanding of their structure-function relation. Historically, single DNA strands remained one the most difficult classes of biomolecular specimens to image, due to low electron scattering strength of its constituent elements....
doctoral thesis 2019
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Noguera López, J. (author)
The creation of artificial cells with the minimal set of components to exhibit self-maintenance, self-reproducibility and evolvability (in other words, to be considered alive) is one of the most exciting areas within the field of synthetic biology. Such entities, here called minimal cells, are constructed by either the top-down or bottom-up...
doctoral thesis 2019
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Fu, Y. (author)
When high-temperature steels are loaded under under industrially relevant conditions not only creep (i.e. a time dependent strain increase even under nominally constant loading conditions) occurs, but also local damage is formed. At relatively short exposure times quasi-spherical micron-sized cavities form preferentially at the grain boundaries...
doctoral thesis 2022
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Rejali, R. (author)
This thesis focuses on possible platforms for a bottom-up approach towards realizing and characterizing atomically assembled magnetic and electronic artificial lattices. For this, we make use of the scanning tunneling microscope (STM), which provides a local probe of the magnetic and electronic properties of the sample and allows for the atom-by...
doctoral thesis 2022
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Maddalena, L. (author)
Optogenetics is a powerful addition to the spectrum of techniques available in neuroscience to investigate neurophysiology and unravel how neural circuit structure is related to circuit function. This technique relies on introducing lightsensitive proteins or molecules as actuators to transduce an optical signal into a physiological perturbation...
doctoral thesis 2022
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Chandrashekar, A. (author)
Most physical phenomena be it mechanical, chemical or biological are inherently nonlinear in nature. In fact, it is the linear phenomenon that is the exception rather than the rule. By harnessing these nonlinearities one can obtain far greater information about the underlying physics and develop more sensitive and efficient devices. This is...
doctoral thesis 2022
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Agbana, T.E. (author)
Malaria remains an important cause of high morbidity and mortality worldwide. According to World Health Organisation (WHO) malaria report for 2017, malaria accounted for the death of 435,000 people. It is the leading cause of death among pregnant women and little children. 11% of maternal and 20% of under–five deaths are attributed to malaria...
doctoral thesis 2020
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Deb Roy, S. (author)
The basis of this thesis has been the curiosity, however modest, to understand how DNA replication happens in vivo, particularly during the onset of DNA damage and beyond. DNA damage is a recurring phenomenon, which a (bacterial) cell faces in its lifetime from the environment or even its inherent metabolism. While we understand much about...
doctoral thesis 2020
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Dreesens, L.L. (author)
Phages are nanomachines composed of a protein coat encapsulating a genome. Since they are metabolically inert, they depend on a bacterial host for replication. They are abundantly present in all kinds of environments, patiently awaiting their target. The nanoscopic mechanical details of how phages or phage-like particles find the correct target...
doctoral thesis 2021
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Krielaart, M.A.R. (author)
We propose a microscopy scheme for the controlled modulation of the electron wave front that utilizes patterned electron mirrors. The ability to control the wave front of the electron finds many applications in electron microscopy, for instance in contrast enhancement techniques, beam mode conversion, low-dose imaging techniques such as quantum...
doctoral thesis 2021
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Bijster, R.J.F. (author)
In this thesis a proof-of-principle demonstration is developed that uses the heat flux between a probe and a sample as a proxy for their separation. The proposed architecture uses a probe that consists of a bilayer cantilever with an attached sphere at its free end. The deflection of the cantilever that is caused by the heat input is measured...
doctoral thesis 2021
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