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Gil Arranja, A. (author), Hennink, W. E. (author), Denkova, A.G. (author), Hendrikx, R.W.A. (author), Nijsen, J. F.W. (author)The aim of this study was the development of radioactive holmium phosphate microspheres (HoPO<sub>4</sub>-MS) with a high holmium content and that are stable in human serum for selective internal radiation therapy (SIRT) of liver cancer. To this end, holmium acetylacetonate microspheres (HoAcAc-MS) were prepared (34.2 ± 1.0 µm in diameter,...journal article 2018
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- Vente, M.A.D. (author), De Wit, T.C. (author), Van den Bosch, M.A.A.J. (author), Bult, W. (author), Seevinck, P.R. (author), Zonnenberg, B.A. (author), De Jong, H.W.A.M. (author), Krijger, G.C. (author), Bakker, C.J.G. (author), Van Het Schip, A.D. (author), Nijsen, J.F.W. (author) journal article 2009
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Vente, M.A.D. (author), Nijsen, J.F.W. (author), De Roos, R. (author), Van Steenbergen, M.J. (author), Kaaijk, C.N.J. (author), Koster-Ammerlaan, M.J.J. (author), De Leege, P.F.A. (author), Hennink, W.E. (author), Van het Schip, A.D. (author), Krijger, G.C. (author)Poly(L-lactic acid) microspheres loaded with holmium-166 acetylacetonate (166Ho-PLLA-MS) are a novel microdevice for intra-arterial radioembolization in patients with unresectable liver malignancies. The neutron activation in a nuclear reactor, in particular the gamma heating, damages the 166Ho-PLLA-MS. The degree of damage is dependent on the...journal article 2009
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Vente, M.A.D. (author), Nijsen, J.F.W. (author), De Wit, T.C. (author), Seppenwoolde, J.H. (author), Krijger, G.C. (author), Seevinck, P.R. (author), Huisman, A. (author), Zonneneberg, B.A. (author), Van den Ingh, T.S.G.A.M. (author), Van het Schip, A.D. (author)Purpose The aim of this study is to evaluate the toxicity of holmium-166 poly(l-lactic acid) microspheres administered into the hepatic artery in pigs. Methods Healthy pigs (20–30 kg) were injected into the hepatic artery with holmium-165-loaded microspheres (165HoMS; n?=?5) or with holmium-166-loaded microspheres (166HoMS; n?=?13). The...journal article 2008