Identification of Large-Scale Structures in Turbulence

This thesis aims to automatically and reliably detect large-scale structures in turbulent flows. To achieve this, a U-net (a type of neural network) is trained using artificially generated data. From the network output, continuous structures are derived and general statistics, including, volume fraction, relative kinetic energy and length scales...

Amyloid-beta plaque quantification and analysis

Alzheimer's disease (AD) is becoming more prevalent as the world population gets older. The formation of Amyloid-beta (\AB) plaques is one of the pathologies related to AD. Recent work has shown that the \ab load in brain tissue has a negative correlation with cognitive performance in cognitively healthy centenarians. <br/>This work aims to...

Exploring deep learning to improve allelic peak calling in forensic DNA analysis

When processing a trace DNA sample at the Netherlands Forensic Institute, an STR electropherogram can be created. An analyst uses this electropherogram and analysis software to read out peaks signifying DNA. After analysis, the DNA profile is used in the interpretation process, which can include the comparison to a reference DNA profile of a...

Fully convolutional architecture vs sliding-window CNN for corneal endothelium cell segmentation

Background<br/><br/>Corneal endothelium (CE) images provide valuable clinical information regarding the health state of the cornea. Computation of the clinical morphometric parameters requires the segmentation of endothelial cell images. Current techniques to image the endothelium in vivo deliver low quality images, which makes automatic...