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Dostanic, M. (author)The high death toll of cardiovascular diseases worldwide and the lack of effective treatments for them are the main motivation for developing alternative and more efficient models for cardiac drug development and disease research. The missing link between current laboratory research on static in vitro and animal models and the clinical stage...doctoral thesis 2023
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Braem, Sarah (author)Drug efficacy and side effects are significantly impacted by the first-pass metabolism, a sequence of events that occurs in the stomach and the liver after oral ingestion. Accurate prediction of this mechanism is crucial for a faster and more cost-efficient drug development process. Replicating the first-pass metabolism in vitro using standard...master thesis 2023
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Neji, Saliha (author)Diamond color centers have been increasingly gaining attention in research due to their desirable optical properties that make them suitable for applications such as quantum computing, quantum sensing and quantum communication. However, the main challenge has been on-chip integration of diamond color centers with high scalability and high yield....master thesis 2023
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- van Dobben de Bruyn, J. (author) doctoral thesis 2023
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Loozen, G.B. (author)Optofluidic lab-on-a-chips (LOCs) employing a dual-waveguide trap for optical trapping and Raman spectroscopy have proven to be attractive and potent tools for high throughput chemical fingerprinting of bio-particles for disease diagnosis. Among the relevant bio-particles are extracellular vesicles (EVs) which a been proven through recent...doctoral thesis 2023
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Michalica, Thomas (author)3D-multi-electrode arrays (3D-MEAs) are needed to overcome the limitations of 2D-multi-electrode arrays (2D-MEAs) and enable the electrical characterization of 3D neuronal cultures in in vitro brain models, advancing the understanding of neurological disorders and paving the way to personalized medicine. The aim of this thesis was to overcome...master thesis 2023
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Huang, Jiongyu (author)A Spiking neural network (SNN) is a type of artificial neural network which encodes information using spike timing, network structure, and synaptic weights to emulate the information processing function of the human brain. Within an SNN, it is always required to support the spike transmission that travels between neurons(array). This thesis aims...master thesis 2023
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Elhassan, Shiemaa (author)An Organ-on-a-Chip (OoC) is a microfluidic device that mimics an organ function on a chip. The goal of the OoC technology is to create disease models of various organs and use them to minimise animal testing. One of the important parameters to maintain the cells/tissues on the OoC is the temperature, typically at 37 °C. Usually, cell culture...master thesis 2023
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Sattari, R. (author), Hu, D. (author), Liu, X. (author), van Zeijl, H.W. (author), Vollebregt, S. (author), Zhang, Kouchi (author)The rapid development of power electronics has challenged the thermal integrity of semiconductor packaging. Further developments in this domain can be supported significantly by utilizing fast and flexible thermal characteristic evaluation. This study employs the transient dual interface method (TDIM) to characterize and compare the thermal...journal article 2023
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Dostanic, M. (author), Windt, Laura (author), Wiendels, Maury (author), van Meer, Berend J. (author), Mummery, Christine L. (author), Sarro, Pasqualina M (author), Mastrangeli, Massimo (author)We present a novel design of elastic micropillars for tissue self-assembly in engineered heart tissue (EHT) platforms. The innovative tapered profile confines reproducibly the tissue position along the main micropillar axis, increasing the accuracy of tissue contraction force measurement. Polydimethylsiloxane-based pillars were designed and...conference paper 2023
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Hua, Yuan (author), Lu, Qi (author), Li, Shuangmu (author), Zhao, B. (author), Du, S. (author)This brief presents a 48V-to-1V 10-level dual inductor hybrid converter (DIHC) containing 11 on-chip switches and an off-chip gallium nitride (GaN) switch. Thanks to the 10-level Dickson switched-capacitor (SC) circuit, most of the voltage stress will be taken over by off-chip capacitors, which reduces the voltage stress of each switch to 4.8...journal article 2023
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Lu, Qi (author), Li, Shuangmu (author), Zhao, B. (author), Jiang, Junmin (author), Chen, Zhiyuan (author), Du, S. (author)Multiple voltage conversion ratio (VCR) recursive switched-capacitor (SC) dc-dc converters, based on several basic 2:1 converters, are widely used for on-chip power supplies due to their flexible VCRs for higher energy efficiency. However, conventional multiple VCR SC converters usually have one or more 2:1 converters unused for some VCRs,...journal article 2023
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R KANNAN, Shirley (author)Organs-on-Chips (OoCs) are micro-engineered devices in which small samples of human-organ tissue are cultured on the substrate. A chip is designed in such a way that it can emulate the in-vivo physiological environment for disease modeling and drug screening. OoC technology can be incorporated into the drug development process from early drug...master thesis 2022
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Pfaiffer, Filippo (author)Engineered Heart Tissues (EHTs) are a valuable approach enabled by Organ-on-Chip (OoC) technology to model human cardiac tissue. These small microfluidic devices allow the culture and development of living cardiac cells in 3D structures, to reproduce tissue dynamics and functionality in-vitro, thus fostering the development of new and more...master thesis 2022
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den Boer, Sophie (author)In vitro models are fundamental in the study of cell behaviour, the physiological function of organs, and their response to drugs and toxins. However, the shortage of accurate and reliable in vitro models calls for the development of in vitro lung models that better recapitulate lung physiology and pathology. Lung-on- a-chip models are promising...master thesis 2022
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Angenent, Maricke (author)Cardiorenal Syndrome (CRS) is a multi-organ disease characterized by a reciprocal pathological interaction between the heart and kidneys during acute or chronic injury. Yet, a complete understanding of the underlying bi-directional pathophysiological mechanisms is lacking, hence obscuring effective diagnostic strategies, patient stratification...master thesis 2022
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Bokhorst, Rik (author)Front-end Monolithic Microwave Integrated Circuits (MMICs) have recently become commercially available for frequencies above 100 GHz. However, achieving low-loss and broadband interconnections between the antenna and MMICs is challenging for integrated front ends at these frequencies. This thesis presents the characterization of a flip-chip...master thesis 2022
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Marting, Louis (author)Terahertz astronomy has been exceptionally unexplored until the last decades due to a technological gap, but exactly at these wavelengths the most distant galaxies appear very bright. Efficient instruments that are capable of spectrometry are essential in understanding the physics of these distant objects. Within the framework of this thesis, an...master thesis 2022
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HUA, YUAN (author)This thesis presents a 48V-to-1V 10-level dual inductor hybrid converter (DIHC) containing 11 on-chip switches and an off-chip Gallium Nitride (GaN) switch. Thanks to the 10-level Dickson switched-capacitor (SC) circuit, most of the voltage stress will be taken over by off-chip capacitors, which reduces the voltage stress of each switch to 4.8 V...master thesis 2022
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Horsthuis, Jan (author)Capillary self-alignment shows the potential to keep small components aligned using soft liquid contact when disturbed by external forces. Whilst this concept has been promising, mostly static situations have been investigated, making it unclear how a receptor-droplet-chip (RDC) configuration behaves dynamically and where its stability limits...master thesis 2022