Development of a hollow fiber membrane microfluidic system to predict human pharmacokinetics in vitro

Drug efficacy and side effects are significantly impacted by the first-pass metabolism, a sequence of events that occurs in the stomach and the liver after oral ingestion. Accurate prediction of this mechanism is crucial for a faster and more cost-efficient drug development process. Replicating the first-pass metabolism in vitro using standard...

A robust material for the production of microfluidic liquid-liquid extraction chips: Evaluation of a robust ALD coating to reduce irradiation-induced surface modifications on polymers and quartz for the usage of microfluidic liquid-liquid extraction chips

Microfluidic extraction is a promising alternative for existing extraction methods of radioisotopes due to the high surface-to-volume ratio. When assessing the compatibility of microfluidic material with the extraction system, there are three critical aspects—compatibility with organic solvents, compatibility with the radiochemistry, and, most...