Development and validation of a bone quality measurement method integrated into the freehand drilling process

<b>Background:</b> Low bone quality associated with osteoporosis is an increasing health issue. The reduction in bone quality increases the risk of bone fractures and implant failure in osteosynthesis. Implant failure can be avoided by adapting the surgical procedure and postoperative care to the bone quality. This requires knowledge of the...

Determining the speed of sound in curved bones

Current research on osteoporosis detection and transcranial imaging suggests that it is necessary to find a method to calculate the speed of sound in curved bones. A popular method to find the speed of sound in bones is by the bidirectional axial transmission technique. Currently, this method assumes that the arrival time of the head wave...

Nuclear factor erythroid 2–related factor 2 (Nrf2) deficiency causes age-dependent progression of female osteoporosis

Background: Nuclear factor erythroid 2–related factor 2 (Nrf2) is a crucial transcription factor for cellular redox homeostasis. The association of Nrf2 with elderly female osteoporotic has yet to be fully described. The aim was to elucidate a potential age-dependent Nrf2 contribution to female osteoporosis in mice. Methods: Eighteen female...

Effect of unfocused extracorporeal shockwave therapy on bone mineral content of twelve distal forearms of postmenopausal women: a clinical pilot study

Summary: Extracorporeal shockwave therapy showed a pronounced effect on bone mass in previous animal studies. We showed in this pilot study that a single treatment with unfocused shockwave therapy in unselected patients does not show side effects. Although our study did not show any effect of shockwave on BMD, the limited sample size does not...

Statistical Appearance Models for Fast and Automated Estimation of Proximal Femur Fracture Risk Using Finite Element Models

Use of DXA-measured aBMD is the common method to predict osteoporotic hip fractures in clinical settings. However, taking only the changes in aBMD into consideration is not enough to explain the whole variety of low energy fractures. It is deemed essential to develop alternative methods that also reflect the influence of other parameters (e.g....