Searched for: subject%3A%22pharmacokinetics%22
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van Schie, J.J.N. (author), Lavini, Cristina (author), van Vliet, L.J. (author), Kramer, Gem (author), Pieters - van den Bos, Indra (author), Marcus, H.J.J. (author), Stoker, Jaap (author), Vos, F.M. (author)
Background: Pharmacokinetic (PK) models can describe microvascular density and integrity. An essential component of PK models is the arterial input function (AIF) representing the time-dependent concentration of contrast agent (CA) in the blood plasma supplied to a tissue. Purpose/Hypothesis: To evaluate a novel method for subject-specific...
journal article 2018
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Poot, D.H.J. (author), van der Heijden, R.A.J. (author), van Middelkoop, Marienke (author), Oei, Edwin H.G. (author), Klein, S. (author)
Purpose: To identify the optimal combination of pharmacokinetic model and arterial input function (AIF) for quantitative analysis of blood perfusion in the patellar bone using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Materials and Methods: This method design study used a random subset of five control subjects from an...
journal article 2018
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Kouwenberg, J.J.M. (author)
Objective: Prostate cancer remains one of the most prevalent forms of cancer in men aged over 65 years, with yearly around 11,200 new cases and 2,600 deaths in the Netherlands. Diagnosis of prostate cancer still relies on biopsies, which are unpleasant and invasive procedures for the patient. The new PET tracer, [68Ga]Sarabesin 3, aims to offer...
master thesis 2015
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Bol, K. (author), Haeck, J.C. (author), Alic, L. (author), Bernsen, M. (author), De Jong, M. (author), Niessen, W.J. (author), Veenland, J.F. (author)
Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) is becoming an indispensable tool to noninvasively study tumor characteristics. However, many different DCE-analysis methods are currently being used. To compare and validate different methods, histology is the gold standard. For this purpose, exact co-localization between histology...
conference paper 2011
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Jongen, C. (author), De Bruin, K. (author), Beekman, F.J. (author), Booij, J. (author)
Purpose: The dopamine D2 receptor (D2R) is important in the mediation of addiction. [123I]iodobenzamide (IBZM), a SPECT ligand for the D2R, has been used for in vivo studies of D2R availability in humans, monkeys, and rats. Although mouse models are important in the study of addiction, [123I]IBZM has not been used in mice SPECT studies. This...
journal article 2008
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