Definitive treatment for early-stage breast cancer with FLASH proton therapy: Dosimetric feasibility and optimization with intensity-modulated ridge filtered beams and toxicity-model endpoints

The aim of this thesis is to study the dosimetric feasibility of FLASH proton therapy for early-stage breast cancer patients. The biological effect of FLASH is seen under ultra-high dose-rates conditions and is beneficial in the damage to healthy tissue. The FLASH effect could enable the clinical feasibility of definitive radiotherapy for low...

FLASH optimisation in clinical IMPT treatment planning: optimisation and evaluation of stereotactic lung treatment plans with proton transmission beams

Radiotherapy (RT) is an important modality in treatment against cancer. Developments in this modality are necessary for improvement of patient complications and survival. Aside from fractionation and precise irradiation, FLASH radiotherapy could be a third way to significantly increase the therapeutic window of radiotherapy.The FLASH effect is a...