Searched for: subject%3A%22reductive%255C+amination%22
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document
Jongkind, E.P.J. (author), Fossey-Jouenne, Aurélie (author), Mayol, Ombeline (author), Zaparucha, Anne (author), Vergne-Vaxelaire, Carine (author), Paul, C.E. (author)
Access to chiral amines with more than one stereocentre remains challenging, although an increasing number of methods are emerging. Here we developed a proof-of-concept bi-enzymatic cascade, consisting of an ene reductase and amine dehydrogenase (AmDH), to afford chiral diastereomerically enriched amines in one pot. The asymmetric reduction...
journal article 2021
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Coeck, R. (author), Meeprasert, J. (author), Li, G. (author), Altantzis, T. (author), Bals, S. (author), Pidko, E.A. (author), De Vos, D. (author)
The reductive amination of benzoic acid and its derivatives would be an effective addition to current synthesis methods for benzylamine. However, with current technology it is very difficult to keep the aromaticity intact when starting from benzoic acid, and salt wastes are often generated in the process. Here, we report a heterogeneous...
journal article 2021
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Hollmann, F. (author), Opperman, Diederik J. (author), Paul, C.E. (author)
Reductions play a key role in organic synthesis, producing chiral products with new functionalities. Enzymes can catalyse such reactions with exquisite stereo-, regio- and chemoselectivity, leading the way to alternative shorter classical synthetic routes towards not only high-added-value compounds but also bulk chemicals. In this review we...
review 2020
document
Gacs, Jenő (author), Zhang, W. (author), Knaus, Tanja (author), Mutti, Francesco G. (author), Arends, I.W.C.E. (author), Hollmann, F. (author)
The consecutive photooxidation and reductive amination of various alcohols in a cascade reaction were realized by the combination of a photocatalyst and several enzymes. Whereas the photocatalyst (sodium anthraquinone-2-sulfonate) mediated the light-driven, aerobic oxidation of primary and secondary alcohols, the enzymes (various ω...
journal article 2019
Searched for: subject%3A%22reductive%255C+amination%22
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