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Automated Assessment of T2-Weighted MRI to Differentiate Malignant and Benign Primary Solid Liver Lesions in Noncirrhotic Livers Using Radiomics

Starmans, M.P.A. (author), Miclea, Razvan L. (author), Vilgrain, Valerie (author), Ronot, Maxime (author), Purcell, Yvonne (author), Verbeek, Jef (author), Niessen, W.J. (author), Klein, Stefan (author), Thomeer, Maarten G. (author)

Rationale and Objectives: Distinguishing malignant from benign liver lesions based on magnetic resonance imaging (MRI) is an important but often challenging task, especially in noncirrhotic livers. We developed and externally validated a radiomics model to quantitatively assess T2-weighted MRI to distinguish the most common malignant and...

journal article 2024

document

Rapid Whole-Knee Quantification of Cartilage Using T ₁, T ₂ ^∗, and T _RAFF2 Mapping With Magnetic Resonance Fingerprinting

Tourais, Joao (author), Ploem, T.W. (author), Zadelhoff, Tijmen A.van (author), Steeg-Henzen, Christal van de (author), Oei, Edwin H.G. (author), Weingärtner, S.D. (author)

Objective: Quantitative Magnetic Resonance Imaging (MRI) holds great promise for the early detection of cartilage deterioration. Here, a Magnetic Resonance Fingerprinting (MRF) framework is proposed for comprehensive and rapid quantification of T ₁, T ₂ ^∗, and T _RAFF2 with whole-knee coverage....

journal article 2023

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CMOS integrated circuits for the quantum information sciences

Anders, Jens (author), Babaie, M. (author), Bashir, Imran (author), Charbon, Edoardo (author), Geck, Lotte (author), Ibrahim, Mohamed I. (author), Sebastiano, F. (author), Staszewski, R.B. (author), Vladimirescu, A. (author)

Over the past decade, significant progress in quantum technologies has been made, and hence, engineering of these systems has become an important research area. Many researchers have become interested in studying ways in which classical integrated circuits can be used to complement quantum mechanical systems, enabling more compact, performant...

journal article 2023

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Resistance to developing brain pathology due to vascular risk factors: the role of educational attainment

van Arendonk, Joyce (author), Yilmaz, Pinar (author), Steketee, Rebecca (author), Zijlmans, Jendé L. (author), Lamballais, Sander (author), Niessen, W.J. (author), Neitzel, Julia (author), Ikram, M. Arfan (author), Vernooij, Meike W. (author)

Brain pathology develops at different rates between individuals with similar burden of risk factors, possibly explained by brain resistance. We examined if education contributes to brain resistance by studying its influence on the association between vascular risk factors and brain pathology. In 4111 stroke-free and dementia-free community...

journal article 2021

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Assessment of turbulent blood flow and wall shear stress in aortic coarctation using image-based simulations

Perinajová, R. (author), Juffermans, J.F. (author), Mercado, Jonhatan Lorenzo (author), Aben, Jean Paul (author), Ledoux, Leon (author), Westenberg, Jos J.M. (author), Lamb, Hildo J. (author), Kenjeres, S. (author)

In this study, we analyzed turbulent flows through a phantom (a 180^∘ bend with narrowing) at peak systole and a patient-specific coarctation of the aorta (CoA), with a pulsating flow, using magnetic resonance imaging (MRI) and computational fluid dynamics (CFD). For MRI, a 4D-flow MRI is performed using a 3T scanner. For CFD, the...

journal article 2021

document

Effects of Simulated Error-Sources on Different 3-D CSI-EPT Strategies

Leijsen, Reijer L. (author), Brink, Wyger M. (author), Webb, A. (author), Remis, R.F. (author)

Three-dimensional contrast source inversion-electrical properties tomography (3-D CSI-EPT) is an iterative reconstruction method that estimates the electrical properties of tissue from transmit field magnetic resonance data. However, in order to bring 3-D CSI-EPT into practice for complex tissue structures and to understand the origin and...

journal article 2021

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Contralateral parenchymal enhancement on MRI is associated with tumor proteasome pathway gene expression and overall survival of early ER+/HER2-breast cancer patients

Ragusi, Max A.A. (author), Bismeijer, Tycho (author), van der Velden, Bas H.M. (author), Loo, Claudette E. (author), Canisius, Sander (author), Wesseling, Jelle (author), Wessels, L.F.A. (author), Elias, Sjoerd G. (author), Gilhuijs, Kenneth G.A. (author)

Purpose: To assess whether contralateral parenchymal enhancement (CPE) on MRI is associated with gene expression pathways in ER+/HER2-breast cancer, and if so, whether such pathways are related to survival. Methods: Preoperative breast MRIs were analyzed of early ER+/HER2-breast cancer patients eligible for breast-conserving surgery included...

journal article 2021

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Low-field magnetic resonance imaging using multiplicative regularization

de Leeuw den Bouter, M.L. (author), van Gijzen, M.B. (author), Remis, R.F. (author)

In this paper we present a magnetic resonance imaging (MRI) technique that is based on multiplicative regularization. Instead of adding a regularizing objective function to a data fidelity term, we multiply by such a regularizing function. By following this approach, no regularization parameter needs to be determined for each new data set...

journal article 2021

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Proton density fat fraction of the spinal column: an MRI cadaver study

Losch, M.S. (author), Swamy, A. (author), Elmi-Terander, Adrian (author), Edström, Erik (author), Hendriks, B.H.W. (author), Dankelman, J. (author)

Background: The increased popularity of minimally invasive spinal surgery calls for a revision of guidance techniques to prevent injuries of nearby neural and vascular structures. Lipid content has previously been proposed as a distinguishing criterion for different bone tissues to provide guidance along the interface of cancellous and...

journal article 2021

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Clinical performance and future potential of magnetic resonance thermometry in hyperthermia

Feddersen, Theresa V. (author), Hernandez-Tamames, J.A. (author), Franckena, Martine (author), van Rhoon, G.C. (author), Paulides, Margarethus M. (author)

Hyperthermia treatments in the clinic rely on accurate temperature measurements to guide treatments and evaluate clinical outcome. Currently, magnetic resonance thermometry (MRT) is the only clinical option to non-invasively measure 3D temperature distributions. In this review, we evaluate the status quo and emerging approaches in this...

review 2020

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Improved Simultaneous Multi-Slice Imaging for Perfusion Cardiac MRI Using Outer Volume Suppression and Regularized Reconstruction

Demirel, Omer Burak (author), Weingärtner, S.D. (author), Moeller, Steen (author), Akcakaya, Mehmet (author)

Perfusion cardiac MRI (CMR) is a radiation-free and noninvasive imaging tool which has gained increasing interest for the diagnosis of coronary artery disease. However, resolution and coverage are limited in perfusion CMR due to the necessity of single snap-shot imaging during the first-pass of a contrast agent. Simultaneous multi-slice (SMS)...

conference paper 2020

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Sensor fusion for magneto-inductive navigation

Wahlström, Johan (author), Kok, M. (author), Porto Buarque de Gusmão, Pedro (author), Abrudan, Traian E. (author), Trigoni, Niki (author), Markham, Andrew (author)

Magneto-inductive navigation is an inexpensive and easily deployable solution to many of today’s navigation problems. By utilizing very low frequency magnetic fields, magneto-inductive technology circumvents the problems with attenuation and multipath that often plague competing modalities. Using triaxial transmitter and receiver coils, it is...

journal article 2020

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Differential diagnosis and mutation stratification of desmoid-type fibromatosis on MRI using radiomics

Timbergen, Milea J.M. (author), Starmans, Martijn P.A. (author), Padmos, Guillaume A. (author), Grünhagen, Dirk J. (author), van Leenders, Geert J.L.H. (author), Hanff, D. F. (author), Niessen, W.J. (author), Klein, S. (author), Visser, J.J. (author)

Purpose: Diagnosing desmoid-type fibromatosis (DTF) requires an invasive tissue biopsy with β-catenin staining and CTNNB1 mutational analysis, and is challenging due to its rarity. The aim of this study was to evaluate radiomics for distinguishing DTF from soft tissue sarcomas (STS), and in DTF, for predicting the CTNNB1 mutation types....

journal article 2020

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Potential of MRI in radiotherapy mediated by small conjugates and nanosystems

Fauzia, R.P. (author), Denkova, A.G. (author), Djanashvili, K. (author)

Radiation therapy has made tremendous progress in oncology over the last decades due to advances in engineering and physical sciences in combination with better biochemical, genetic and molecular understanding of this disease. Local delivery of optimal radiation dose to a tumor, while sparing healthy surrounding tissues, remains a great...

journal article 2019

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Conjugate gradient variants for ℓ _p -regularized image reconstruction in low-field MRI

de Leeuw den Bouter, M.L. (author), van Gijzen, M.B. (author), Remis, R.F. (author)

We consider the MRI physics in a low-field MRI scanner, in which permanent magnets are used to generate a magnetic field in the millitesla range. A model describing the relationship between measured signal and image is derived, resulting in an ill-posed inverse problem. In order to solve it, a regularization penalty is added to the least...

journal article 2019

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Developments in electrical-property tomography based on the contrast-source inversion method

Leijsen, R.L. (author), Fuchs, P.S. (author), Brink, Wyger (author), Webb, A. (author), Remis, R.F. (author)

The main objective of electrical-property tomography (EPT) is to retrieve dielectric tissue parameters from B ₁ ⁺ data as measured by a magnetic-resonance (MR) scanner. This is a so-called hybrid inverse problem in which data are defined inside the reconstruction domain of interest. In this paper, we discuss recent and...

journal article 2019

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Comparison between dynamic gadoxetate-enhanced MRI and ^99m Tc-mebrofenin hepatobiliary scintigraphy with SPECT for quantitative assessment of liver function

Rassam, F. (author), Zhang, T. (author), Cieslak, K. P. (author), Lavini, C. (author), Stoker, J. (author), Bennink, R. J. (author), van Gulik, T. M. (author), van Vliet, L.J. (author), Runge, J. H. (author), Vos, F.M. (author)

Objectives: To compare Gd-EOB-DTPA dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) with ^99m Tc-mebrofenin hepatobiliary scintigraphy (HBS) as quantitative liver function tests for the preoperative assessment of patients undergoing liver resection. Methods: Patients undergoing liver surgery and preoperative assessment...

journal article 2019

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First-Order Induced Current Density Imaging and Electrical Properties Tomography in MRI

Fuchs, P.S. (author), Mandija, Stefano (author), Stijnman, Peter R.S. (author), Brink, Wyger M. (author), van den Berg, Cornelis A.T. (author), Remis, R.F. (author)

In this paper, we present an efficient dedicated electrical properties tomography (EPT) algorithm (called first-order current density EPT ) that exploits the particular radio frequency field structure, which is present in the midplane of a birdcage coil, to reconstruct conductivity and permittivity maps in this plane from B ^ + 1 data. The...

journal article 2018

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High-Permittivity Pad Design for Dielectric Shimming in Magnetic Resonance Imaging Using Projection-Based Model Reduction and a Nonlinear Optimization Scheme

van Gemert, J.H.F. (author), Brink, W.M. (author), Webb, A. (author), Remis, R.F. (author)

Inhomogeneities in the transmit radio frequency magnetic field ( {\text{B}}-{1}^{+} ) reduce the quality of magnetic resonance (MR) images. This quality can be improved by using high-permittivity pads that tailor the {\text{B}}-{1}^{+} fields. The design of an optimal pad is application-specific and not straightforward and would therefore...

journal article 2018

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Semiautomatic Assessment of the Terminal Ileum and Colon in Patients with Crohn Disease Using MRI (the VIGOR++ Project)

Puylaert, Carl A.J. (author), Schüffler, Peter J. (author), Naziroglu, R.E. (author), Tielbeek, Jeroen A.W. (author), Li, Z. (author), Makanyanga, Jesica C. (author), Tutein Nolthenius, Charlotte J. (author), Nio, C. Yung (author), Pendsé, Douglas A. (author), Menys, Alex (author), Ponsioen, Cyriel Y. (author), Atkinson, David (author), Forbes, Alastair (author), Buhmann, Joachim M. (author), Fuchs, Thomas J. (author), Hatzakis, Haralambos (author), van Vliet, L.J. (author), Stoker, Jaap (author), Taylor, Stuart A. (author), Vos, F.M. (author)

Rationale and Objectives: The objective of this study was to develop and validate a predictive magnetic resonance imaging (MRI) activity score for ileocolonic Crohn disease activity based on both subjective and semiautomatic MRI features. Materials and Methods: An MRI activity score (the “virtual gastrointestinal tract [VIGOR]” score) was...

journal article 2018