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Nagtegaal, M.A. (author)Magnetic Resonance Imaging (MRI) is a flexible medical imaging technique that facilitates measurement of a wide range of contrasts particularly in soft tissue (e.g. brain and heart). Conventionally, qualitative images are acquired in which certain physical tissue properties are emphasized such as the transverse and longitudinal relaxation times....doctoral thesis 2023
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Smit, Jean-Paul (author)Deep-learning (DL) models could greatly advance the automation of fact-checking, yet have not widely been adopted by the public because of their hard-to-explain nature. Although various techniques have been proposed to use local explanations for the behaviour of DL models, little attention has been paid to global explanations. <br/>In response,...bachelor thesis 2023
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Wang, W. (author), van Keulen, A. (author), Wu, J. (author)Additive manufacturing of metal parts involves phase transformations and high temperature gradients which lead to uneven thermal expansion and contraction, and, consequently, distortion of the fabricated components. The distortion has a great influence on the structural performance and dimensional accuracy, e.g., for assembly. It is therefore...journal article 2023
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Koppensteiner, Sarah (author), van Velthoven, J.T. (author), Voigtlaender, Felix (author)Continuing previous work, this paper provides maximal characterizations of anisotropic Triebel-Lizorkin spaces F˙p,qα for the endpoint case of p= ∞ and the full scale of parameters α∈ R and q∈ (0 , ∞]. In particular, a Peetre-type characterization of the anisotropic Besov space B˙∞,∞α=F˙∞,∞α is obtained. As a consequence, it is shown that...journal article 2023
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Dekking, F.M. (author)We discuss the base 3/2 representation of the natural numbers. We prove that the sum-of-digits function of the representation is a fixed point of a 2-block substitution on an infinite alphabet, and that this implies that sum-of-digits function modulo 2 of the representation is a fixed point x<sub>3/2</sub> of a 2-block substitution on {0,1}....journal article 2023
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Gil Jimenez, A. (author), van Dorp, Jeroen (author), Contreras-Sanz, Alberto (author), van der Vos, Kristan (author), Vis, Daniel J. (author), Braaf, Linde (author), Broeks, Annegien (author), Kerkhoven, Ron (author), van Kessel, Kim E.M. (author), Wessels, L.F.A. (author)Cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy is recommended for patients with muscle-invasive bladder cancer (MIBC). It has been shown that somatic deleterious mutations in ERCC2, gain-of-function mutations in ERBB2, and alterations in ATM, RB1, and FANCC are correlated with pathological response to NAC in...journal article 2023
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Li, Q. (author), Finn, Adrian J. (author), Doyle, Stephen J. (author), Smith, Robin (author), Kiss, A.A. (author)This paper explores the basis on which reliable screening of distillation sequences for energy-efficient separation of zeotropic multicomponent mixtures can be carried out. A case study for the separation of natural gas liquids is used to demonstrate the approach. To solve this generic problem, a screening algorithm has been developed using...journal article 2023
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Dekking, F.M. (author), Keane, M.S. (author)We consider in general two-block substitutions and their fixed points. We prove that some of them have a simple structure: their fixed points are morphic sequences. Others are intrinsically more complex, such as the Kolakoski sequence. We prove this for the Thue-Morse sequence in base 3/2.journal article 2023
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Koppensteiner, Sarah (author), van Velthoven, J.T. (author), Voigtlaender, Felix (author)This paper provides maximal function characterizations of anisotropic Triebel–Lizorkin spaces associated to general expansive matrices for the full range of parameters p∈ (0 , ∞) , q∈ (0 , ∞] and α∈ R. The equivalent norm is defined in terms of the decay of wavelet coefficients, quantified by a Peetre-type space over a one-parameter dilation...journal article 2023
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Nadeem, A. (author), Verwer, S.E. (author)Sequence clustering in a streaming environment is challenging because it is computationally expensive, and the sequences may evolve over time. K-medoids or Partitioning Around Medoids (PAM) is commonly used to cluster sequences since it supports alignment-based distances, and the k-centers being actual data items helps with cluster...conference paper 2023
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Wang, Lechen (author), Mao, Jianfeng (author), Li, L. (author), Li, Xuechun (author), Tu, Yilei (author)Predicting Estimated Time of Arrival (ETA) for a Multi-Airport System (MAS) is much more challenging than for a single airport system because of complex air route structure, dense air traffic volume and vagaries of traffic conditions in an MAS. In this work, we propose a novel “Bubble” mechanism to accurately predict medium-term ETA for a...journal article 2023
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Izquierdo-Lara, Ray W. (author), Heijnen, Leo (author), Oude Munnink, Bas B. (author), Schapendonk, Claudia M.E. (author), Elsinga, Goffe (author), Langeveld, J.G. (author), Post, Johan (author), Prasad, Divyae K. (author), Medema, G.J. (author)Monitoring of SARS-CoV-2 in wastewater (WW) is a promising tool for epidemiological surveillance, correlating not only viral RNA levels with the infection dynamics within the population, but also to viral diversity. However, the complex mixture of viral lineages in WW samples makes tracking of specific variants or lineages circulating in the...journal article 2023
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Calderon Franco, D. (author), van Loosdrecht, Mark C.M. (author), Abeel, T.E.P.M.F. (author), Weissbrodt, D.G. (author)The transformation of environmental microorganisms by extracellular DNA is an overlooked mechanism of horizontal gene transfer and evolution. It initiates the acquisition of exogenous genes and propagates antimicrobial resistance alongside vertical and conjugative transfers. We combined mixed-culture biotechnology and Hi-C sequencing to...journal article 2023
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van der Sluis, Tetje C. (author), Beyrend, Guillaume (author), van der Gracht, Esmé T.I. (author), Abdelaal, T.R.M. (author), Jochems, Simon P. (author), Belderbos, Robert A. (author), Wesselink, Thomas H. (author), van Duikeren, Suzanne (author), Arens, Ramon (author)Immune checkpoint therapy (ICT) has the power to eradicate cancer, but the mechanisms that determine effective therapy-induced immune responses are not fully understood. Here, using high-dimensional single-cell profiling, we interrogate whether the landscape of T cell states in the peripheral blood predict responses to combinatorial targeting...journal article 2023
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Hoogendoorn, Rik (author)During arrival waves at hub airports the surrounding airspaces can be congested, resulting in flight delays. To solve this congestion problem one of the current solutions is to sequence flights whilst they are still en-route by using an Extended Arrival Manager (E-AMAN). This paper aims at improving this E-AMAN concept by tackling two of its...master thesis 2022
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van Frankenhuijzen, Timo (author)Labour shortage in the logistic sector and the poor work conditions as a baggage handler are a major and highly relevant problem for airports around the world. A solution is provided by Vanderlande Industies: a baggage loading robot. Since the efficiency of the stacking process is sufficient, operators that overlook the robot must intervene...master thesis 2022
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van Velzen, Daan (author)Preferential Attachment models offer an explanation for why power laws are so common in real-world data. In these models, we start out with an initial network and add nodes one at a time. For each new node, we make m connections to existing nodes and if we define the attachment probability of attaching to a vertex to be proportional to its...master thesis 2022
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Miaskiwskyi, L.T. (author)The subject of this thesis is twofold: The first part is the study of local-to-global principles for the continuous Lie algebra (co-)homology of certain infinite-dimensional Lie algebras of geometric origin, specifically, Gelfand-Fuks cohomology and continuous cohomology of gauge algebras. It includes both an exposition to classical results of...doctoral thesis 2022
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Ureña Baltierra, Gerardo (author)Mimetic formulations, also known as structure-preserving methods, are numerical schemes that preserve fundamental properties of the continuous differential operators at a discrete level. Additionally, they are well-known for satisfying constraints such as conservation of mass or momentum. <br/><br/>In the present work, a Mimetic Spectral Element...master thesis 2022
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Florescu, Stefanos (author)Over the past 20 years, the cost of sequencing genomes has reduced drastically. As DNA data grows at an unprecedented rate, the need for fast and affordable software and hardware solutions for DNA analysis is higher than ever. A critical and time-consuming component in any DNA analysis pipeline is sequence alignment, which refers to mapping...master thesis 2022