Reconfigurable architecture for compression-only structures

The standard way of building consists on average of 7000 parts and processes which in combination with the decrease in productivity within the construction sector limits the number of actors that can be involved. However, this leads to a housing shortage in many countries. The production of homes should be accessible, affordable and should offer...

Integrated Array Tomography for 3D Correlative Light and Electron Microscopy

Volume electron microscopy (EM) of biological systems has grown exponentially in recent years due to innovative large-scale imaging approaches. As a standalone imaging method, however, large-scale EM typically has two major limitations: slow rates of acquisition and the difficulty to provide targeted biological information. We developed a 3D...

Multiscale characterization of pathological bone tissue

Bone is a complex natural material with a complex hierarchical multiscale organization, crucial to perform its functions. Ultrastructural analysis of bone is crucial for our understanding of cell to cell communication, the healthy or pathological composition of bone tissue, and its three-dimensional (3D) organization. A variety of techniques...

Determining the angles of squat cracks via CT scanning and metallographic observations

This study investigates the angles θ₁, θ₂, and θ₃ that squat crack faces form with respect to three orthogonal planes: the rail top, the longitudinal-vertical cross-section and the lateral-vertical cross-section. Rail samples with squats of various severities are obtained from the field. Their three...

Fletcher: A framework to efficiently integrate FPGA accelerators with apache arrow

Modern big data systems are highly heterogeneous. The components found in their many layers of abstraction are often implemented in a wide variety of programming languages and frameworks. Due to language implementation differences, interfaces between these components, including hardware accelerated components, are often burdened by...

Improvement of Production and Isolation of Human Neuraminidase-1 in Cellulo Crystals

In cellulo crystallization is a developing technique to provide crystals for protein structure determination, particularly for proteins that are difficult to prepare by in vitro crystallization. This method has a key advantage: It requires neither a protein purification step nor a crystallization step. However, there is still no systematic...

Data Curation for Preclinical and Clinical Multimodal Imaging Studies

Purpose: In biomedical research, imaging modalities help discover pathological mechanisms to develop and evaluate novel diagnostic and theranostic approaches. However, while standards for data storage in the clinical medical imaging field exist, data curation standards for biomedical research are yet to be established. This work aimed at...

Model-Based Compensation for Serial Manipulators through Semi-Parametric Gaussian Process Regression

Industrial robots can be found in automotive, food, chemical, and electronics industries. These robots are often caged and are secluded from human beings. A recent trend in a subclass of industrial robots named collaborative robots allows the humans to interact with the robots safely. The word “safety” mentioned above is of supreme importance....

Multi-core architecture for anonymous Internet streaming

There are two key components for high throughput distributed anonymizing applications. The first key component is overhead due to message complexity of the utilized algorithms. The second key component is an nonscalable architecture to deal with this high throughput. These issues are compounded by the need for anonymization. Using a state of the...

Cortical Spreading Depression Causes Unique Dysregulation of Inflammatory Pathways in a Transgenic Mouse Model of Migraine

Familial hemiplegic migraine type 1 (FHM1) is a rare monogenic subtype of migraine with aura caused by mutations in CACNA1A that encodes the α1A subunit of voltage-gated CaV2.1 calcium channels. Transgenic knock-in mice that carry the human FHM1 R192Q missense mutation (‘FHM1 R192Q mice’) exhibit an increased susceptibility to cortical spreading...

A common perspective

A new intervention has been placed in the suburbs of Bogotá. This new design aims to fight the monotony of large infrastructural arteries running through the city, whilst connecting two neighbourhoods and reclaiming space for the pedestrian. A network of pedestrian bridges connect the scattered brick towers and together with the adjacent park...

Smart renovation of residential real estate and neighbourhoods: An exploratory research into the possibilities of open data to support the renovation process in the initiation phase

In this master thesis an exploratory research into the possibly of the implementation of open data in the renovation process of post-war serial built dwellings is described. A user need analysis has been conducted by means of literature review, expert interviews and case studies. This led to a description of the process, the involved...

Three-dimensional characterization of grain boundaries in pure nickel by serial sectioning via mechanical polishing

Five macroscopic boundary parameters can be extracted from three-dimensional orientation maps. Serial sectioning, which includes consecutive steps of material removal, and electron backscatter diffraction (EBSD) measurement were employed to extract a stack of two-dimensional sections of a pure nickel sample. The EBSD patterns were collected from...

A statically balanced mobile arm support based on a novel spring system

This research is focused on designing a close-to-body statically balanced mobile arm support for people suffering from degenerative muscular conditions. The arm support is based on a spring system consisting of two bi-articular zero-free-length springs to balance the arm.

Parameter analysis for the design of statically balanced serial linkages using a stiffness matrix approach with Cartesian coordinates

A statically balanced system is in equilibrium in every pose. In classical balancing solutions for serial linkages, each DOF is balanced by an independent element. Disadvantages are increased mass and inertia for counter-mass, and auxiliary links for spring solutions. Recent literature presents a method for balancing serial linkages without...

Physical design of a 3D router: Reducing the number of vertical connections and enabling asynchronous operation

With the use of multi-core architectures, the Network-on-Chip (NoC) became an important research topic. The most important benefit of a NoC compared to a communication bus is that it is scalable. The heart of the NoC is the router, which provides the communication between different computational units. This component is highly suitable to be a...

amdSYM, a new dominant recyclable marker cassette for Saccharomyces cerevisiae

Despite the large collection of selectable marker genes available for Saccharomyces cerevisiae, marker availability can still present a hurdle when dozens of genetic manipulations are required. Recyclable markers, counterselectable cassettes that can be removed from the targeted genome after use, are therefore valuable assets in ambitious...