Searched for: subject%3A%22single%255C-cell%255C+RNA%255C+sequencing%22
(1 - 9 of 9)
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Michielsen, L.C.M. (author), Reinders, M.J.T. (author), Mahfouz, A.M.E.T.A. (author)
Most regulatory elements, especially enhancer sequences, are cell population-specific. One could even argue that a distinct set of regulatory elements is what defines a cell population. However, discovering which non-coding regions of the DNA are essential in which context, and as a result, which genes are expressed, is a difficult task. Some...
journal article 2024
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Stol, Madelon (author)
Understanding the role of genes and genetic variants is a key challenge in unraveling the driving mechanisms of Alzheimer's disease (AD). Single-cell RNA sequencing is a technique that quantifies gene expression at the cell (type) level enabling investigation of the roles of different cell types in disease. We analyzed changes in gene (co-...
master thesis 2023
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Golik, Bartek (author)
Analysing single-cell RNA sequencing data is becoming an increasingly tedious task as the size of data sets grows. As a proposed solution, recent discoveries suggest that these data sets can be binarized without losing much information. This in turn should allow for memory and time efficient methods of storage and computation. Numerous analyses...
bachelor thesis 2023
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van der Sluis, Tetje C. (author), Beyrend, Guillaume (author), van der Gracht, Esmé T.I. (author), Abdelaal, T.R.M. (author), Jochems, Simon P. (author), Belderbos, Robert A. (author), Wesselink, Thomas H. (author), van Duikeren, Suzanne (author), Arens, Ramon (author)
Immune checkpoint therapy (ICT) has the power to eradicate cancer, but the mechanisms that determine effective therapy-induced immune responses are not fully understood. Here, using high-dimensional single-cell profiling, we interrogate whether the landscape of T cell states in the peripheral blood predict responses to combinatorial targeting...
journal article 2023
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Drummer, Francesca (author)
Single-cell sequencing allows measuring individual cells' molecular features and their responses to perturbations. Understanding which cells respond to a particular perturbation and how these responses vary across populations can be used to, for example, improve vaccine immunogenicity. However, an exhaustive exploration of single-cell...
master thesis 2022
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Biharie, Kirti (author)
Knowing the relation between cell types is crucial for translating experimental results from mice to humans. Establishing cell type matches, however, is hindered by the biological differences between the species. A substantial amount of evolutionary information between genes that could be used to align the species, is discarded by most of the...
master thesis 2022
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Viho, Eva M.G. (author), Buurstede, Jacobus C. (author), Berkhout, Jari B. (author), Mahfouz, A.M.E.T.A. (author), Meijer, Onno C. (author)
Glucocorticoid stress hormones are powerful modulators of brain function and can affect mood and cognitive processes. The hippocampus is a prominent glucocorticoid target and expresses both the glucocorticoid receptor (GR: Nr3c1) and the mineralocorticoid receptor (MR: Nr3c2). These nuclear steroid receptors act as ligand-dependent...
journal article 2021
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Yu, W. (author), Mahfouz, A.M.E.T.A. (author), Reinders, M.J.T. (author)
The power of single-cell RNA sequencing (scRNA-seq) in detecting cell heterogeneity or developmental process is becoming more and more evident every day. The granularity of this knowledge is further propelled when combining two batches of scRNA-seq into a single large dataset. This strategy is however hampered by technical differences between...
journal article 2021
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Verhagen, Mathijs (author)
Cancer metastasis, the spread of cancer to distant organs, is the major cause of cancerrelated mortality. Hence, understanding the mechanisms underlying cancer metastasis is crucial to improve clinical interventions. Despite intensive efforts, the driving mechanisms remain ill-understood due to the difficulties posed by studying the different...
master thesis 2019
Searched for: subject%3A%22single%255C-cell%255C+RNA%255C+sequencing%22
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