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de Vries, M. (author), Wijntjes, M. (author), Sikorski, J. (author), Moreira, P. (author), van de Berg, N.J. (author), van den Dobbelsteen, J.J. (author), Misra, S. (author)Conformity of tumour volumes and dose plans in prostate brachytherapy (BT) can be constrained by unwanted needle deflections, needle access restrictions and visualisation limitations. This work validates the feasibility of teleoperated robotic control of an active steerable needle using magnetic resonance (MR) for guidance. With this system,...journal article 2023
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Sickler, Hanna (author)Prostate cancer is the most frequently diagnosed cancer type among men, and the third deathliest form of cancer. Several treatments are available to treat prostate cancer. Low Dose Rate Brachytherapy (LDR BT) is one of them, which inserts permanent radioactive seeds into the prostate using a needle. The literature review performed prior to this...master thesis 2022
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de Vries, M. (author), Klaassen, N. J.M. (author), Morsink, N. C. (author), van Nimwegen, S. A. (author), Nijsen, J. F.W. (author), van den Dobbelsteen, J.J. (author)Microbrachytherapy with radioactive holmium-166 (166Ho) microspheres (MS) has the potential to be an effective treatment method for brain malignancies. Direct intratumoural delivery of 166Ho-MS and dose coverage of the whole tumour are crucial requirements. However, currently no dedicated instruments for controlled intratumoural delivery...journal article 2021
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Nobel, Max (author)Prostate cancer is the most common cancer in men and third in terms of mortality. High dose rate brachytherapy is a common and effective treatment to treat this cancer. High dose rate brachytherapy requires the implantation of several needles into the prostate trough which a radiation source is introduced. This implantation can present a number...master thesis 2020
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Kemp, Charlotte (author)This graduation project consists of the design of the needle control device for MRI-guided interventions. It is an apparatus that grabs and steers a flexible needle remotely, so it could be used in an MRI while the physician controls the needle based on the scans. In this way, the physician has a clear sight of the position of the needle and the...master thesis 2020
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de Lange, Danny (author)PURPOSE. The purpose of this thesis is to investigate the possibility of implementing a prototype of a steerable needle in a medical procedure. Therefore the two main research questions are: “Can the intended user perform a steering motion with the steerable needle and reach the target area following a straight and curved trajectory?” and “Does...master thesis 2019
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Hoogenstraaten, Amy (author)Radiofrequency ablation (RFA) is a localized thermalintervention technique with the purpose to destroy small tumours (< 3 cm) byheating the tumour tissue. Due to various challenges with targeting andvisualisation during RFA, the clinical need of steerable needles is present forradiologists. Helwig, B.P. developed a new...master thesis 2019
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van Duijn, Daan (author)In recent years, more and more medical operations are done minimally invasive. Intervention radiology is a medical specialty which uses minimally invasive techniques to diagnose, or treat diseases. Instruments like needles and catheters are used by radiologists to enter the network of veins and arteries guided by image modalities. A complex...master thesis 2019
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Stolk, Bart (author)Sensory nerve roots (DRGs) that emerge from the spinal cord can be stimulated with electrodes to prevent neuropathic pain. Proper functionality of DRG stimulation strongly depends on electrode placement, and conventional pre-curved introduction shafts limit DRG coverage of the implanted electrode lead. The goal of this thesis is to design an...master thesis 2019
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de Vries, Martijn (author)Brain cancer is a major health problem and currently used treatment methods are considered suboptimal. Micro-brachytherapy with radioactive Holmium-166 showed to be an effective palliative care method for primary and metastatic brain tumors and intratumoral administration with holmium microspheres (HoMS) showed very promising results with...master thesis 2018
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van de Berg, N.J. (author), Sánchez-Margallo, Juan A. (author), Langø, Thomas (author), van den Dobbelsteen, J.J. (author)Radio frequency ablation is commonly used in the treatment of hepatocellular carcinoma. Clinicians rely on imaging techniques, such as medical ultrasound, to confirm an accurate needle placement. This accuracy may improve by means of active needle steering techniques, which are currently in development. Needle steering will likely increase the...conference paper 2018
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De Falco, I. (author), Culmone, C. (author), Menciassi, Arianna (author), Dankelman, J. (author), van den Dobbelsteen, J.J. (author)Needles are advanced tools commonly used in minimally invasive medical procedures. The accurate manoeuvrability of flexible needles through soft tissues is strongly determined by variations in tissue stiffness, which affects the needle-tissue interaction and thus causes needle deflection. This work presents a variable stiffness mechanism for...journal article 2018
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de Jong, T.L. (author), van de Berg, N.J. (author), Tas, L. (author), Moelker, Adriaan (author), Dankelman, J. (author), van den Dobbelsteen, J.J. (author)Purpose: Accurate and precise needle placement is of utmost importance in interventional radiology. However, targeting can be challenging due to, eg, tissue motion and deformation. Steerable needles are a possible solution to overcome these challenges. The present work studied the clinical need for steerable needles. We aimed to answer three...journal article 2018
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Veldhoven, Paulien (author)Flexible steerable needles can follow curved paths inside the human body, allowing to steer around objects, to adjust for mispunctures, and to reach multiple targets. However, the designs of existing ultra-thin (diameter < 1 mm) steerable needles require axial rotation of the needle to steer in 3D space causing needle twisting, which results...master thesis 2017
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Schrier, Tim (author)Background <br/>Current procedures for repairing damage to the articular cartilage in the ankle are not satisfying patient needs and have a minimum rehabilitation time of 4 months. The Chondro project aims to develop an all-in-one polyclinical procedure where diagnosis, treatment and rehabilitation can be performed in one session reducing the...master thesis 2017
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Scali, M. (author), Pusch, T.P. (author), Breedveld, P. (author), Dodou, D. (author)High accuracy and precision in reaching target locations inside the human body is necessary for the success of percutaneous procedures, such as tissue sample removal (biopsy), brachytherapy, and localized drug delivery. Flexible steerable needles may allow the surgeon to reach targets deep inside solid organs while avoiding sensitive structures ...review 2017
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Scali, M. (author), Kreeft (student), Davey (author), Breedveld, P. (author), Dodou, D. (author)Flexible steerable needles can follow complex curved paths inside the human body. In a previous work, we developed a multiple-part steerable needle prototype with a diameter of 1.2 mm, inspired by the ovipositor of parasitoid wasps. The needle consisted of seven nickel-titanium longitudinally aligned wires held together at the tip by a...conference paper 2017
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van de Berg, N.J. (author)Needle interventions play an important role both during the diagnosis and treatment of liver cancer. However, due to intermediate anatomical structures, such as the ribs and lungs, deep seated lesions are not always directly accessible. In addition, instrument-tissue interaction forces may cause needles to deflect during insertion. This leads to...doctoral thesis 2016
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Pusch, T.P. (author)In many percutaneous interventions, such as biopsies and brachytherapy, accuracy in reaching a specific target inside the human body is necessary for the success of the procedure. Maneuvering to the target site is challenging, particularly if sensitive structures such as blood vessels have to be avoided. For maneuvering along a curved trajectory,...student report 2016
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Nanut, I. (author)Percutaneous procedures are minimally invasive medical procedures that use needles to locally operate on a target in a patient’s body. The precise placement of the needle in the body is a challenging task that can affect the quality and efficiency of these procedures. Needle insertion accuracy may be improved by robot-assisted control of...master thesis 2013