Altered wall shear stresses in embryonic chicken outflow tract due to homocysteine exposure

The embryonic heart is already beating before cardiac morphogenesis is complete. Therefore, the effect of blood flow on cardiogenesis has been subject of many studies. Shear stress, acting on the endocardial cells, has been shown to alter the expression of shear-responsive genes implicated in heart development. The congenital heart defects (CHDs...