Development of a Multichannel TCSPC System in a Spartan 6 FPGA LinoSPAD - Fluorescence Lifetime Imaging for Fluorescence Guided Surgery

For the master project work was carried out for the development of a fluorescence lifetime imaging probe for fluorescence guided surgery. For this project a prototype was designed. The work on the prototype was divided into three main parts, hardware, firmware / software, and system / optics. In this thesis the firmware / software of the system...

Implementation, Characterization, and Optimization of an FPGA-based Time-to-Digital Converter

Many fields need high performance time measurements, including Single-Photon Avalanche Diode (SPAD) cameras, Positron Emission Tomography (PET) systems, and other time-of-flight systems. These measurements are often performed by means of time-to-digital converters, that for these applications, require high resolution, accuracy, and throughput....

A 1 GSa/s Deep Cryogenic, Reconfigurable Soft-core FPGA ADC for Quantum Computing Applications

Analog interfacing is the only way to communicate with a quantum processor, whether it is applying qubit operations or reading their quantum states. There exist other applications where analog interfacing is abundant, e.g. sensor networks, automotive, industrial control, etc. In those applications the use of FPGAs is continuously growing,...

Data Acquisition System Design for a 160x128 Single-photon Image Sensor with On-pixel 55 ps Time-to-digital Converter

Time-resolved image sensors enabling picosecond resolutions over large formats are needed in many advanced imaging fields, from fluorescence lifetime imaging microscopy (FLIM) to positron emission tomography (PET). Integrated single-photon avalanche diode (SPAD) technology embodies the new frontiers of time-resolved imaging, namely better...

Development and Characterization of an Endoscopic TOF PET System

The endoscopic time-of-flight (TOF) positron emission tomography (PET) concept has many advantages compared with the traditional PET system. It improves the image quality by delivering higher spatial resolution and enhancing the signal-to-noise ratio. Implementing the endoscopic TOF PET system in an ultrasonic probe requires an ultra...