F. Zhang
6 records found
1
Authored
For dry powder inhaled formulations, good flow behaviour is vital in re-dispersing the powder. However, inhaled drug powders with a particle size below 10 µm are classified as highly cohesive materials with poor flow characteristics. Here we demonstrate how to alter the flow p ...
Sticking of particles has a tremendous impact on powder-processing industries, especially for hygroscopic amorphous powders. A wide variety of experimental methods has been developed to measure at what combinations of temperature and moisture content material becomes sticky. T ...
Atomic layer deposition in a fluidized bed is utilised for the coating of polyamide powders with thin films of silicon dioxide. By varying the number of exposure cycles the amount of deposited material can be precisely controlled, allowing for tailoring wetting, flowing, and m ...
Ideal controlled pulmonary drug delivery systems provide sustained release by retarding lung clearance mechanisms and efficient lung deposition to maintain therapeutic concentrations over prolonged time. Here, we use atomic layer deposition (ALD) to simultaneously tailor the r ...
Drug powders with tunable wettability by atomic and molecular layer deposition
From highly hydrophilic to superhydrophobic
The wettability of pharmaceuticals is a key physical property which influences their dissolution rate, dispersibility, flowability and solid-state stability. Here, we provide a platform of surface nanoengineering methods capable of tuning the wettability of drug powders from h ...
Fluidization of fine lactose for dry powder inhalation
A comparison of assisting methods
Fluidization of cohesive pharmaceutical powders is difficult to achieve and typically requires the introduction of external forces. This study investigates the fluidization of the fine inhalation grade of lactose powders (size range from 0.1-20 μm) that are specifically develo ...