Soft wearable sensors offer promising potential for advanced diagnostics, therapeutics, and human–machine interfaces. Unlike conventional devices that are bulky and rigid, often compromising skin integrity, comfort, and user compliance, soft wearable sensors are flexible, conformable, and better suited to the dynamic skin surface. This improved mechanical integration enhances signal fidelity and device performance, while also enabling safer, more comfortable, and continuous physiological monitoring in real-world environments. Driven by advances in materials science and engineering, soft wearable sensors are overcoming the mechanical limitations of traditional bioelectronics, paving the way for personalized healthcare and next-generation robotics.