Fiber-metal laminates are a well-known and established material concept featuring an enhanced crack propagation resistance when compared to their metal and fiber reinforced plastic (FRP) constituents. In this paper, this approach is transferred to purely carbon fiber reinforced plastic (CFRP) based laminates made from layers having polyetherimide (PEI) and epoxy matrices in an alternating laminate architecture. The laminates are manufactured via hot pressing. Double-cantilever beam (DCB) tests are performed on standard samples for both the hybrid laminates in different configurations as well for the both constituent materials, i.e. carbon fiber reinforced PEI (CFR-PEI) and carbon fiber reinforced epoxy. As the formation of an interphase is already reported in literature for this matrix combination, microstructural investigations have also been carried out in addition to fractography on crack surfaces. It is shown that the hybrid materials outperform both constituents regarding the crack resistance when crack initiation starts in the tougher CFR-PEI layer and the laminate layup is 0/90°. In the other configurations investigated, there is no significant effect. The energy dissipating mechanisms are crack jumping and the formation of several parallel cracks. Consequently, crack resistance in such hybrids might be controlled in future by adjusting the crack resistance of the constituents as well as the laminate architecture.