J
Jeroen G.J.
7 records found
1
Authored
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage
genome-wide association study totaling 111,326 c ...
genome-wide association study totaling 111,326 c ...
Background
Corneal endothelium (CE) images provide valuable clinical information regarding the health state of the cornea. Computation of the clinical morphometric parameters requires the segmentation of endothelial cell images. Current techniques to image the endothelium in viv
...
Clinical parameters related to the corneal endothelium can only be estimated by segmenting endothelial cell images. Specular microscopy is the current standard technique to image the endothelium, but its low SNR make the segmentation a complicated task. Recently, we proposed a ...
Characterization of pathogenic SORL1 genetic variants for association with Alzheimer's disease
A clinical interpretation strategy
Accumulating evidence suggests that genetic variants in the SORL1 gene are associated with Alzheimer disease (AD), but a strategy to identify which variants are pathogenic is lacking. In a discovery sample of 115 SORL1 variants detected in 1908 Dutch AD cases and controls, we ...