This thesis describes techniques to reduce the offset error in precision instrumentation and operational amplifiers. The offset error which is considered a major error source associated with gain blocks, together with other errors are reviewed. Conventional and newer approaches to remove offset and low frequency noise are discussed, with a focus on the work of this thesis “Chopper-Stabilized Auto-Zeroed Chopper Instrumentation Amplifiers”. The technique is demonstrated through the application of a Current Feedback Instrumentation Amplifier (CFIA) as a Dynamic Offset Cancelation (DOC) methods; therefore achieves offset cancellation in real-time. In addition, major advantages and disadvantages of other techniques of offset cancellations are described, and compared throughout several chapters.