The degree of supply chain risk faced by many companies has risen dramatically and the impact of disruptions can cascade easily across companies’ and countries’ borders. To handle this increased vulnerability, systematic approaches and decision making tools are needed to provide support in managing supply chain disruptions. In this thesis, an integrated process: InForMDRiSC, and an agent-based simulation framework are presented and discussed. These two contributions are complementary means for managing supply chain disruptions. InForMDRiSC describes the steps to be followed in managing supply chain disruptions, whereas the simulation framework supports the building of simulation models for specific supply chains which enable decision makers to experiment with different strategies and tactics to prevent or recover from supply chain disruptions.