To maintain the competitive advantage after bad years in 2012 and 2013 Air France – KLM – Martinair Cargo (KLM Cargo) got the vision to, amongst others measures, shift their focus towards pharmaceutical freight, also referred to as ‘pharma’. Pharma is an interesting commodity because of the stability of the growth of the pharmaceutical industry, the freight is high-yield and it is possible to transport the freight in the hull, the belly, of the passenger aircraft. The latter fits the developments in the fleet where a gradually push-off is planned for the full-freighter aircraft. Another development affecting KLM Cargo freight operations at Amsterdam Airport Schiphol (AAS) is the airport’s plan to expand its passenger terminal. KLM Cargo needs to make way for this expansion and need to relocate their freight terminal. For the development of the new terminal ‘Innovation’, ‘Lean’ and ‘Safety’ are spear points. Considering the attention the company is giving to pharma, it is their wish to handle pharmaceutical freight in a dedicated terminal. The objective of this research is to make recommendations to KLM Cargo about the design of a new terminal for dedicated handling of pharmaceutical freight by developing and sizing a conceptual design for the internal organization of the terminal fitted to KLM Cargo’s product structure, the pharmaceutical industry, and future developments in demand and regulation...