Protein stabilisation and controlled particulate production by supercritical fluid drying

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Abstract

Carbon dioxide was used as a drying medium for the preparation of micro-size powders from aqueous solutions in a high-pressure spray-drying process. This technology was shown to be an alternative to traditional drying processes that could be successfully used for the dry formulation of therapeutic proteins, the preparation of stable amorphous products, the selective production of polymorphs and pseudomorphs, and the design of particles.