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1 Hepatotoxicity of paracetamol and structural analogues : molecular mechanisms of bioactivation and of chemoprotection
dissertation 2000    
Author: Bessems, J.
Keywords: Nutrition
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2 3,5-disubstituted analogues of paracetamol; synthesis, analgesic activity and cytotoxicity
article 1995    
Author: Bessems, J.G.M.
Keywords: Chemistry

3 Toxicological profile for o-benzyl-p-chlorophenol
article 1998    
Author: Stouten, H. · Bessems, J.G.M.
Keywords: Nutrition · Effects · Hazard assessment · Kinetics · o-benzo-p-chlorophenol · Review · Toxicity · chlorophenol · disinfectant agent · phenol derivative · animal experiment · animal model · carcinogenicity · cleaning · controlled study · health hazard · hospital · human · male · occupational exposure · occupational toxicology · priority journal · rat · review · toxicity · toxicology · xenobiotic metabolism · Administration, Oral · Adult · Animals · Dichlorophen · Disinfectants · Female · Housekeeping, Hospital · Humans · Male · Middle Aged · Mutagenicity Tests · Occupational Exposure · Personnel, Hospital · Rabbits · Rats · Reproduction · Skin · Tissue Distribution
[Abstract]

4 Improving the applicability of (Q)SARs for percutaneous penetration in regulatory risk assessment.
article 2008    
Author: Bouwman, T. · Cronin, M.T. · Bessems, J.G. · Sandt, J.J. van de
Keywords: Health · xenobiotic agent · article · biological model · chemistry · drug effect · European Union · government regulation · human · legal aspect · physiology · prediction and forecasting · quantitative structure activity relation · risk assessment · skin absorption · European Union · Government Regulation · Humans · Models, Biological · Predictive Value of Tests · Quantitative Structure-Activity Relationship · Risk Assessment · Skin Absorption · Xenobiotics
[Abstract]

5 Oral-to-inhalation route extrapolation in occupational health risk assessment: A critical assessment
article 2004    
Author: Rennen, M.A.J. · Bouwman, T. · Wilschut, A. · Bessems, J.G.M. · Heer, C.de
Keywords: Health Chemistry · Food and Chemical Risk Analysis · Inhalation · Local effects · Oral · Respiratory · Risk assessment · Route extrapolation · Accuracy · Analytical error · Data base · Inhalation · Intermethod comparison · Occupational exposure · Occupational hazard · Priority journal · Quantitative analysis · Reliability · Risk assessment · Screening test · Administration, Inhalation · Administration, Oral · Animals · Dose-Response Relationship, Drug · Humans · Models, Biological · No-Observed-Adverse-Effect Level · Occupational Exposure · Pesticides · Predictive Value of Tests · Research Design · Risk Assessment · Species Specificity
[Abstract]

6 Development of a QSAR for worst case estimates of acute toxicity of chemically reactive compounds
article 2007    
Author: Freidig, A.P. · Dekkers, S. · Verwei, M. · Zvinavashe, E. · Bessems, J.G.M. · Sandt, J.J.M. van de
Keywords: Biology · Analytical research · Biomedical research · Acute rodent toxicity · In vitro-in vivo correlation · QSAR · chemical compound · acute toxicity · article · clinical research · hazard assessment · in vitro study · in vivo study · LD 50 · mouse · nonhuman · prediction · priority journal · quantitative structure activity relation · rat · reference database · validation study · Algorithms · Animals · Data Interpretation, Statistical · Endpoint Determination · European Union · Forecasting · Hazardous Substances · Humans · Legislation · Lethal Dose 50 · Quantitative Structure-Activity Relationship · Reproducibility of Results · Animalia · Rattus · Rodentia
[Abstract]

7 Subacute (28-day) toxicity of furfural in Fischer 344 rats: A comparison of the oral and inhalation route
article 2004    
Author: Arts, J.H.E. · Muijser, H. · Appel, M.J. · Kuper, C.F. · Bessems, J.G.M. · Woutersen, R.A.
Keywords: Biology Health · Toxicology and Applied Pharmacology · Fischer rat · Furfural · Inhalation · Oral · Route-to-route extrapolation · Subacute toxicity · corn oil · furfural · air · animal experiment · animal model · animal tissue · article · comparative study · concentration response · controlled study · exposure · female · histopathology · kidney mass · liver weight · male · mortality · nonhuman · olfactory epithelium · rat · survival · toxicity testing · Administration, Inhalation · Administration, Oral · Animals · Dose-Response Relationship, Drug · Female · Furaldehyde · Kidney · Liver · Longevity · Male · No-Observed-Adverse-Effect Level · Olfactory Mucosa · Organ Size · Rats · Rats, Inbred F344 · Zea mays
[Abstract]

8 Hydrogen atom abstraction of 3,5-disubstituted analogues of paracetamol by horseradish peroxidase and cytochrome P450
article 1998    
Author: Bessems, J.G.M. · Groot, M.J. de · Baede, E.J. · Koppele, J.M. te · Vermeulen, N.P.E.
Keywords: Nutrition · Analgesic agent · Cytochrome p450 · Horseradish peroxidase · Hydrogen peroxide · Paracetamol · Reduced nicotinamide adenine dinucleotide phosphate · Analgesia · Animal experiment · Animal tissue · Biotransformation · Catalysis · Drug metabolism · Electron spin resonance · Enzyme activity · Liver microsome · Male · Nonhuman · Oxidation · Rat · Acetaminophen · Animals · Cytochrome P-450 CYP1A1 · Cytochrome P-450 CYP2B1 · Cytochrome P-450 CYP2E1 · Cytochrome P-450 Enzyme System · Electron Spin Resonance Spectroscopy · Free Radicals · Horseradish Peroxidase · Hydrogen · Male · Microsomes, Liver · NADP · Oxidation-Reduction · Rats · Rats, Wistar · Thermodynamics · Animalia · Armoracia rusticana · Rickettsia sp. PAR
[Abstract]

9 Neurobehavioural evaluation and kinetics of inhalation of constant or fluctuating toluene concentrations in human volunteers
article 2005    
Author: Lammers, J.H.C.M. · Meuling, W.J.A. · Muijser, H. · Freidig, A.P. · Bessems, J.G.M.
Keywords: Health · Toxicology and Applied Pharmacology · Human · Neurobehaviour · PBTK modelling · Peak exposure · Toluene · Toxicokinetics · ortho cresol · toluene · adolescent · article · attention · blood analysis · brain level · central nervous system function · controlled study · exposure · human · male · memory · mood · motor performance · neurologic examination · normal human · perception · priority journal · qualitative analysis · urinalysis · Animalia
[Abstract]

10 Rat liver microsomal cytochrome P450-dependent oxidation of 3,5-disubstituted analogues of paracetamol
article 1996    
Author: Bessems, J.G.M. · Koppele, J.M. te · Dijk, P.A. van · Stee, L.L.P. van · Commandeur, J.N.M. · Vermeulen, N.P.E.
Keywords: Toxicology · beta naphthoflavone · cytochrome p450 · glutathione · paracetamol · paracetamol derivative · phenobarbital · animal tissue · article · controlled study · drug oxidation · liver microsome · male · nonhuman · rat · Acetaminophen · Animals · Benzoquinones · beta-Naphthoflavone · Cytochrome P-450 Enzyme System · Gas Chromatography-Mass Spectrometry · Glutathione · Imines · Kinetics · Male · Microsomes, Liver · Oxidation-Reduction · Rats · Rats, Wistar · Spectrophotometry, Ultraviolet · Animalia · Armoracia rusticana
[Abstract]

11 Development of good modelling practice for physiologically based pharmacokinetic models for use in risk assessment : The first steps
article 2008    
Author: Loizou, G. · Spendiff, M. · Barton, H.A. · Bessems, J. · Bois, F.Y. · Bouvier d’Yvoire, M. · Buist, H.E. · Clewell III, H.J. · Meek, B. · Gundert-Remy, U. · Goerlitz, G. · Schmitt, W.
Keywords: Biology · Food and Nutrition · Healthy Living
[Abstract]

12 Development of good modelling practice for physiologically based pharmacokinetic models for use in risk assessment: The first steps
article 2008    
Author: Loizou, G. · Spendiff, M. · Barton, H.A. · Bessems, J. · Bois, F.Y. · d'Yvoire, M.B. · Buist, H. · Clewell III, H.J. · Meek, B. · Gundert-Remy, U. · Goerlitz, G. · Schmitt, W.
Keywords: Health · Good modelling practice · PBPK · Risk assessment · article · Canada · documentation · dosimetry · Europe · Greece · priority journal · risk assessment · scientific literature · United States · Animals · Humans · Legislation, Drug · Models, Statistical · Pharmacokinetics · Quantitative Structure-Activity Relationship · Risk Assessment
[Abstract]

13 Human biomonitoring in health risk assessment in Europe: Current practices and recommendations for the future
article 2019    
Author: Louro, H. · Heinälä, M. · Bessems, J. · Buekers, J. · Vermeire, T. · Woutersen, M. · Engelen, J. van · Borges, T. · Rousselle, C. · Ougier, E. · Alvito, P. · Martins, C. · Assunção, R. · Silva, M.J. · Pronk, A. · Schaddelee-Scholten, B. · Gonzalez, M. del carmen · Alba, M. de · Castaño, A. · Viegas, S. · Humar-Juric, T. · Kononenko, L. · Lampen, A. · Vinggaard, A.M. · Schoeters, G. · Kolossa-Gehring, M. · Santonen, T.
Keywords: Risk assessment · Human biomonitoring · ChemicalsInternal exposure · HBM4EU
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 13 of 13 found. | Sort by date