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1 Glutathione conjugation as a bioactivation reaction
article 2000    
Author: Bladeren, P.J. van
Keywords: Nutrition · Bioactivation · Glutathione conjugates · Glutathione S-transferases · Cysteine · Glutathione · Glutathione transferase · Lyase · Catalysis · Chemical binding · Chemical reaction · Chromosomal localization · Conjugation · Covalent bond · Detoxification · Enzyme activation · Enzyme activity · Enzyme induction · Enzyme inhibition · Enzyme mechanism · Gene location · Genetic polymorphism · Human · Nonhuman · Protein expression · Reaction analysis · Reduction · Animals · Biotransformation · Carbon-Sulfur Lyases · Enzyme Induction · Glutathione · Glutathione Transferase · Humans · Metabolic Detoxication, Drug · Oxidation-Reduction · Xenobiotics
[Abstract]

2 Metabolism of reactive chemicals
article 1995    
Author: Bladeren, P.J. van · Ommen, B. van
Keywords: Nutrition

3 Effects of high fat fish oil and high fat corn oil diets on initiation of AOM-induced colonic aberrant crypt foci in male F344 rats
article 2003    
Author: Bladeren, P.J. van · Ommen, B. van
Keywords: Health Biology · Physiological Sciences

4 Dose-dependent kinetics and metabolism of 1,2-dichlorobenzene in rat : effect of pretreatment with phenobarbital
article 1996    
Author: Hissink, A.M. · Ommen, B. van · Bladeren, P.J. van
Keywords: Toxicology · Animals · Bile · Biotransformation · Chlorobenzenes · Chromatography, Gas · Chromatography, High Pressure Liquid · Dose-Response Relationship, Drug · Feces · Hydrolysis · Insecticides · Male · Mass Spectrometry · Phenobarbital · Rats · Rats, Wistar · Tissue Distribution · Animalia · Arene · Rattus norvegicus
[Abstract]

5 Exposure of humans to complex chemical mixtures : hazard identification and risk assessment
article 1998    
Author: Feron, V.J. · Groten, J.P. · Bladeren, P.J. van
Keywords: Workplace · Dangerous goods · Pollutant · Drug Interactions · Environmental Exposure · Environmental Pollutants · Hazardous Substances · Humans · Risk · Risk Assessment
[Abstract]

6 Trichloroethylene risk assessment: relevance of interindividual differences
article 2001    
Author: Vermeulen, N.P.E. · Bladeren, P.J. van
Keywords: Nutrition · Bottom-up · Interindividual variability · PBPK-modeling · Risk assessment · Trichloroethylene
[Abstract]

7 Toxicogenomics of bromobenzene hepatotoxicity: A combined transcriptomics and proteomics approach
article 2003    
Author: Heijne, W.H.M. · Stierum, R.H. · Slijper, M. · Bladeren, P.J. van · Ommen, B. van
Keywords: Toxicology Health · Physiological Sciences · Bromobenzene · cDNA microarray · Hepatotoxicity · Proteomics · Toxicogenomics · Transcriptomics · alpha glutamylcysteine synthetase · bromobenzene · cathepsin L · enzyme · epoxide hydrolase · glutathione · glutathione transferase · heme oxygenase · messenger RNA · peroxiredoxin · proteasome · unclassified drug · animal experiment · animal model · animal tissue · article · controlled study · enzyme activity · enzyme induction · enzyme regulation · enzyme subunit · gene control · gene expression · gene identification · gene induction · genomics · glutathione metabolism · liver toxicity · lysosome · male · nonhuman · nucleotide sequence · oxidative stress · priority journal · protein content · protein degradation · protein depletion · protein expression · protein synthesis · proteomics · rat · RNA analysis · tissue level · unindexed sequence · weight reduction · Animals · Bromobenzenes · Liver · Male · Oligonucleotide Array Sequence Analysis · Pharmacogenetics · Proteomics · Rats · Rats, Wistar · Transcription, Genetic
[Abstract]

8 The role of biotransformation in dietary (anti)carcinogenesis
article 1999    
Author: Iersel, M.L.P.S. van · Verhagen, H. · Bladeren, P.J. van

9 Conjugation of isoprene monoepoxides with glutathione, catalyzed by α, μ, π and θ-class glutathione S-transferases of rat and man
article 1999    
Author: Bogaards, J.J.P. · Venekamp, J.C. · Salmon, F.G.C. · Bladeren, P.J. van
Keywords: Nutrition · Glutathione S-transferase · Isoprene · Metabolism · Polymorphism · Cytochrome p450 · Epoxide · Epoxide hydrolase · Glutathione · Glutathione transferase · Isoprene · Conjugate · Conjugation · Controlled study · High performance liquid chromatography · Human · Liver · Liver metabolism · Mouse · Rat · Xenobiotic metabolism · Animals · Chromatography, High Pressure Liquid · Epoxy Compounds · Glutathione · Glutathione Transferase · Humans · Liver · Mice · Rats · Rats, Wistar · Species Specificity · Subcellular Fractions
[Abstract]

10 Transport of the glutathione conjugate of ethacrynic acid by the human multidrug resistance protein MRP
article 1996    
Author: Zaman, G.J.R. · Cnubben, N.H.P. · Bladeren, P.J. van · Evers, R. · Borst, P.
Keywords: Adenosine Monophosphate · ATP-Binding Cassette Transporters · Biological Transport · Carcinoma, Non-Small-Cell Lung · Cell Membrane · Drug Resistance, Multiple · Ethacrynic Acid · Glutathione · Humans · Kinetics · Lung Neoplasms · Multidrug Resistance-Associated Proteins · Recombinant Proteins · Saccharomyces cerevisiae · Sulfinpyrazone · Transfection · Tumor Cells, Cultured
[PDF] [Abstract]

11 Hepatic epoxide concentrations during biotransformation of 1,2- and 1,4- dichlorobenzene: The use of in vitro and in vivo metabolism, kinetics and PB- PK modeling
article 1996    
Author: Hissink, E. · Ommen, B. van · Bogaards, J.J. · Bladeren, P.J. van
Keywords: Toxicology · 1,2 dichlorobenzene · 1,4 dichlorobenzene · alanine aminotransferase · ascorbic acid · cytochrome p450 isoenzyme · epoxide · glutathione · isoniazid · animal cell · animal experiment · animal model · biotransformation · conference paper · controlled study · detoxification · enzyme substrate · liver microsome · liver toxicity · male · mathematical model · nonhuman · priority journal · rat · toxicokinetics · Animals · Biotransformation · Carcinogens · Chlorobenzenes · Cytochrome P-450 Enzyme System · Epoxy Compounds · Humans · Liver · Male · Microsomes, Liver · Models, Biological · Rats · Rats, Wistar

12 Glutathione conjugation of alkylating cytostatic drugs with a nitrogen mustard group and the role of glutathione S-transferases
article 1996    
Author: Dirven, H.A.A.M. · Ommen, B. van · Bladeren, P.J. van
Keywords: Nutrition

13 Human cytochrome P450 enzyme selectivities in the oxidation of chlorinated benzenes
article 1995    
Author: Bogaards, J.J.P. · Ommen, B. van · Wolf, C.R. · Bladeren, P.J. van
Keywords: Toxicology · Cell Line · Chlorobenzenes · Chlorzoxazone · Chromatography, Gas · Cytochrome P-450 Enzyme System · Ethanolamines · Human · Oxazines · Oxidation-Reduction · Substrate Specificity · Testosterone · Transfection
[Abstract]

14 Toxicology of chemical mixtures : challenges for today and the future
article 1995    
Author: Feron, V.J. · Groten, J.P. · Jonker, D. · Cassee, F.R. · Bladeren, P.J. van
Keywords: Toxicology · Administration, Inhalation · Administration, Oral · Aldehydes · Animals · Drug Interactions · Hazardous Substances · Kidney Diseases · Organ Specificity · Rats · Rats, Wistar · Research Design · Risk Assessment · Toxicity Tests · Xenobiotics · Animalia · Complex mixtures · Defined · Standard setting · Study designs
[Abstract]

15 Beta-napthoflavone- and self-induced metabolism of 3,3',4,4'-tetrachlorobiphenyl in hepatic microsomes of the male, pregnant female and foetal rat
article 1995    
Author: Morse, D.C. · Bladeren, P.J. van · Klasson Wehler, E. · Brouwer, A.
Keywords: Biology

16 Immune effects of hexachlorobenzene in the rat : role of metabolism in a 13-week feeding study
article 1995    
Author: Schielen, P. · Besten, C. den · Vos, J.G. · Bladeren, P.J. van · Seinen, W. · Bloksma, N.
Keywords: Toxicology

17 Biotransformation and toxicity of halogenated benzenes
article 1995    
Author: Besten, C. den · Brouwer, A. · Rietjens, I.M.C.M. · Bladeren, P.J. van
Keywords: Toxicology

18 Involvement of human glutathione S-transferase isoenzymes in the conjugation of cyclophosphamide metabolites with glutathione
article 1994    
Author: Dirven, H.A.A.M. · Ommen, B. van · Bladeren, P.J. van
Keywords: Biology · Biotransformation · Cyclophosphamide · Glutathione · Glutathione Transferase · Human · Isoenzymes · Phosphoramide Mustards · Support, Non-U.S. Gov't
[Abstract]

19 Conjugation of isoprene monoepoxides with glutathione, catalyzed by alpha, mu, pie and teta-class glutathione S-transferases of rat and man
article 1999    
Author: Bogaards, J.J.P. · Venekamp, J.C. · Salmon, F.G.C. · Bladeren, P.J. van
Keywords: Chemistry · analyse · chromatografie

20 The role of biotransformation in dietary (anti)carcinogenesis
article 1999    
Author: Iersel, M.L.P.S. van · Verhagen, H. · Bladeren, P.J. van
Keywords: Nutrition · (Anti)carcinogenic · Biotransformation · Dietary compound · Modulation · Cytochrome p450 · Glutathione transferase · Biotransformation · Cancer risk · Carcinogenesis · Drug detoxification · Enzyme activity · Genetic polymorphism · Human · Nutrition · Priority journal · Review · Biotransformation · Carcinogens · Cytochrome P-450 Enzyme System · Diet · Gene Expression Regulation, Neoplastic · Glutathione Transferase · Humans · Kinetics · Neoplasms · Variation (Genetics) · Xenobiotics
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 99 found. Next | Sort by date