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Showing 1 to 12 of 12 found. | Sort by date

1 The regioselectivity of glutathione adduct formation with flavonoid quinone/quinone methides is pH-dependent
article 2002    
Author: Awad, H.M. · Boersma, M.G. · Boeren, S. · Bladeren, P.J. van · Vervoort, J. · Rietjens, I.M.C.M.
Keywords: Nutrition

2 Structure-activity study on the quinone/quinone methide chemistry of flavonoids
article 2001    
Author: Awad, H.M. · Boersma, M.G. · Boeren, S. · Bladeren, P.J. van · Vervoort, J. · Rietjens, I.M.C.M.
Keywords: Nutrition

3 Effects of flavonoid mixtures on the transport of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through Caco-2 monolayers: An in vitro and kinetic modeling approach to predict the combined effects on transporter inhibition
article 2008    
Author: Schutte, M.E. · Boersma, M.G. · Verhallen, D.A.M. · Groten, J.P. · Rietjens, I.M.C.M.
Keywords: ABC transporters · Caco-2 · Flavonoids · Kinetic modeling · Mixtures · PhIP · 2 amino 1 methyl 6 phenylimidazo[4,5 b]pyridine · Biological Transport, Active · Caco-2 Cells · Carcinogens · Drug Synergism · Flavonoids · Humans · Imidazoles · Models, Biological
[Abstract]

4 A physiologically based biokinetic (PBBK) model for estragole bioactivation and detoxification in rat
article 2008    
Author: Punt, A. · Freidig, A.P. · Delatour, T. · Scholz, G. · Boersma, M.G. · Schilter, B. · Bladeren, P.J. van · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · Bioactivation · Detoxification · Estragole · In vitro · PBPK · Rat · 1' hydroxyestragole glucuronide · 1' sulfooxyestragole · Benzene derivative · Chavicol · Estragole · Glucuronide · Phenol derivative · Unclassified drug · Animal tissue · Arterial blood · Body fat · Controlled study · Detoxification · In vitro study · Kinetics · Liver · Nonhuman · Partition coefficient · Rat · Tissue perfusion · Venous blood · Allyl Compounds · Animals · Anisoles · Carcinogens · Dose-Response Relationship, Drug · Female · Glucuronides · Kidney · Lung · Male · Metabolic Detoxication, Drug · Models, Biological · Phenols · Rats · Rats, Sprague-Dawley · Rats, Wistar · Sulfones · Tissue Distribution · Rattus · Food and Nutrition · Healthy Living
[Abstract]

5 Human glutathione S-transferase-mediated glutathione conjugation of curcumin and efflux of these conjugates in caco-2 cells
article 2007    
Author: Usta, M. · Wortelboer, H.M. · Vervoort, J. · Boersma, M.G. · Rietjens, I.M.C.M. · Bladeren, P.J. van · Cnubben, N.H.P.
Keywords: Biology · Toxicology and Applied Pharmacology · curcumin · glutathione transferase · adult · aged · article · atom · catalysis · cell strain CACO 2 · conjugate · drug degradation · drug excretion · drug structure · female · glutathione metabolism · human · human cell · human tissue · intestine · intestine epithelium cell · liquid chromatography · liver cytosol · male · mass spectrometry · monolayer culture · proton nuclear magnetic resonance · Adult · Aged · Caco-2 Cells · Curcumin · Cytosol · Female · Glutathione · Glutathione Transferase · Humans · Intestines · Liver · Magnetic Resonance Spectroscopy · Male · Metabolic Detoxication, Phase II · Middle Aged · Molecular Structure
[Abstract]

6 Computer-modeling-based QSARs for analyzing experimental data on biotransformation and toxicity
article 2001    
Author: Soffers, A.E.M.F. · Boersma, M.G. · Vaes, W.H.J. · Vervoort, J. · Tyrakowska, B. · Hermens, J.L.M. · Rietjens, I.M.C.M.
Keywords: Nutrition

7 Human cytochrome P450 enzyme specificity for the bioactivation of estragole and related alkenylbenzenes
article 2007    
Author: Jeurissen, S.M.F. · Punt, A. · Boersma, M.G. · Bogaards, J.J.P. · Fiamegos, Y.C. · Schilter, B. · Bladeren, P.J. van · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · 1' hydroxyestragole · alkenylbenzene derivative · alpha naphthoflavone · benzene derivative · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2C19 · cytochrome P450 2D6 · cytochrome P450 2E1 · estragole · methyleugenol · safrole · article · enzyme specificity · human · human cell · hydroxylation · liver microsome · phenotype · protein expression · Anisoles · Biotransformation · Chromatography, High Pressure Liquid · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Eugenol · Flavoring Agents · Humans · Hydroxylation · Microsomes, Liver · Safrole · Substrate Specificity
[Abstract]

8 Interplay between MRP Inhibition and Metabolism of MRP Inhibitors: The Case of Curcumin
article 2003    
Author: Wortelboer, H.M. · Usta, M. · Velde, A.E. van der · Boersma, M.G. · Spenkelink, B. · Zanden, J.J. van · Rietjens, I.M.C.M. · Bladeren, P.J. van · Cnubben, N.H.P.
Keywords: Biology · Physiological Sciences · curcumin · glutathione · glutathionylcurcumin · multidrug resistance protein 1 · multidrug resistance protein 2 · protein inhibitor · unclassified drug · animal cell · article · controlled study · drug effect · IC 50 · inhibition kinetics · insect cell · intracellular transport · membrane vesicle · metabolism · monolayer culture · nonhuman · protein expression · protein transport · Animals · ATP-Binding Cassette Transporters · Baculoviridae · Cell Line · Curcumin · Cyclosporine · Dinitrochlorobenzene · Dose-Response Relationship, Drug · Drug Resistance, Multiple · Ethacrynic Acid · Fluoresceins · Glutathione · Glutathione Transferase · Humans · P-Glycoprotein · P-Glycoproteins · Propionates · Quinolines · Recombinant Proteins · Spodoptera · Animalia · Apus apus · Insecta
[Abstract]

9 Human cytochrome P450 enzyme specificity for bioactivation of safrole to the proximate carcinogen 1′-hydroxysafrole
article 2004    
Author: Jeurissen, S.M.F. · Bogaards, J.J.P. · Awad, H.M. · Boersma, M.G. · Brand, W. · Fiamegos, Y.C. · Beek, T.A. van · Alink, G.M. · Sudhölter, E.J.R. · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Physiological Sciences · 1' hydroxysafrole · carcinogen · cytochrome P450 · cytochrome P450 2A6 · cytochrome P450 2C9 · cytochrome P450 2D6 · cytochrome P450 2E1 · safrole · unclassified drug · animal cell · article · enzyme activation · enzyme specificity · human · insect cell · microsome · nonhuman · reaction analysis · Biotransformation · Carcinogens · Cytochrome P-450 Enzyme System · Humans · Microsomes, Liver · Risk Assessment · Safrole · Statistics, Nonparametric · Substrate Specificity · Animalia · Insecta
[Abstract]

10 Regioselectivity of phase II metabolism of luteolin and quercetin by UDP-glucuronosyl transferases
article 2002    
Author: Boersma, M.G. · Woude, H. van der · Bogaards, J. · Boeren, S. · Vervoort, J. · Cnubben, N.H.P. · Iersel, M.L.P.S. van · Bladeren, P.J. van · Rietjens, I.M.C.M.
Keywords: Nutrition

11 The pro-oxidant chemistry of the natural antioxidants vitamin C, vitamin E, carotenoids and flavonoids
article 2002    
Author: Rietjens, I.M.C.M. · Boersma, M.G. · Haan, L. de · Spenkelink, B. · Awad, H.M. · Cnubben, N.H.P. · Zanden, J.J. van · Woude, H. van der · Alink, G.M. · Koeman, J.H.
Keywords: Environment
[Abstract]

12 Human cytochrome P450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1′-hydroxymethyleugenol
article 2006    
Author: Jeurissen, S.M.F. · Bogaards, J.J.P. · Boersma, M.G. · Horst, J.P.F. ter · Awad, H.M. · Fiamegos, Y.C. · Beek, T.A. van · Alink, G.M. · Sudhölter, E.J.R. · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · 1' hydroxymethyleugenol · barbituric acid derivative · carcinogen · cytochrome P450 · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2C19 · cytochrome P450 2C9 · cytochrome P450 2D6 · methyleugenol · unclassified drug · article · carcinogenicity · concentration (parameters) · enzyme activation · enzyme kinetics · enzyme specificity · enzyme substrate · human · hydroxylation · incubation time · insect cell · lifestyle · liver microsome · nonhuman · sensitivity analysis · smoking · Aryl Hydrocarbon Hydroxylases · Benzoflavones · Biotransformation · Carcinogens · Cell Line · Cytochrome P-450 CYP1A2 · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Eugenol · Flavoring Agents · Humans · Kinetics · Microsomes, Liver · Mixed Function Oxygenases · Recombinant Proteins · Risk Assessment · Sulfaphenazole · Insecta
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 12 of 12 found. | Sort by date