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1 Effect of different levels of vitamin B6 in the diet of rats on the content of pyridoxamine-5'-phosphate and pyridoxal-5'-phosphate in the liver
article 1982    
Author: Berg, H. van den · Bogaards, J.J.P. · Sinkeldam, E.J. · Schreurs, W.H.P.
Keywords: Nutrition · Biology · Biochemistry

2 The biotransformation of isoprene and the two isoprene monoepoxides by human cytochrome P450 enzymes, compared to mouse and rat liver microsomes
article 1996    
Author: Bogaards, J.J.P. · Venekamp, J.C. · Bladeren, P.J. van
Keywords: Cytochrome P-450 · Isoprene · Metabolism · cyclohexane oxide · cytochrome p450 · cytochrome p450 isoenzyme · epoxide hydrolase · isoprene · animal experiment · article · controlled study · enzyme activity · enzyme specificity · epoxidation · human · human tissue · liver microsome metabolism · mouse · nonhuman · rat · species difference · xenobiotic metabolism · Animals · Biotransformation · Butadienes · Cyclohexanes · Cyclohexenes · Cytochrome P-450 CYP2E1 · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Epoxide Hydrolases · Epoxy Compounds · Hemiterpenes · Humans · Hydrolysis · Mice · Microsomes, Liver · Oxidation-Reduction · Pentanes · Rats · Rats, Wistar · Species Specificity
[Abstract]

3 The novel antifungal agent PLD-118 is neither metabolized by liver microsomes nor inhibits cytochrome P450 in vitro
article 2005    
Author: Parnham, M.J. · Bogaards, J.J.P. · Schrander, F. · Schut, M.W. · Orešković, K. · Mildner, B.
Keywords: Health Pharmacology · Physiological Sciences · Cytochrome P450 · Metabolism · PLD-118 · 2 amino 4 methylenecyclopentanecarboxylic acid · alpha naphthoflavone · amino acid · antifungal agent · bufuralol · chlorzoxazone · coumarin · cytochrome P450 · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2B6 · cytochrome P450 2C19 · cytochrome P450 2C9 · cytochrome P450 2D6 · cytochrome P450 2E1 · cytochrome P450 3A · diclofenac · diethyldithiocarbamic acid · ethoxyresorufin · ketoconazole · mephenytoin · monoclonal antibody · monoclonal antibody 2B6 · quinidine · reduced nicotinamide adenine dinucleotide phosphate · resorufin · sulfaphenazole · testosterone · umbelliferone · unclassified drug · unindexed drug · analytic method · animal tissue · article · candidiasis · concentration response · controlled study · derivatization · dog · drug structure · enzyme assay · enzyme inhibition · enzyme stability · enzyme substrate · fluorescence analysis · high performance liquid chromatography · human · human tissue · in vitro study · liver homogenate · liver microsome metabolism · nonhuman · rat · structure analysis · Administration, Oral · Animals · Antifungal Agents · Chemistry, Pharmaceutical · Cycloleucine · Cytochrome P-450 Enzyme System · Dogs · Drug Evaluation, Preclinical · Humans · Microsomes, Liver · Rats · Ribosomal Proteins
[Abstract]

4 Modelling the responses to biological reactive intermediates : establishing the borderlines of risk
article 2001    
Author: Bladeren, P.J. van · Bogaards, J.J.P. · Cnubben, N.H.P. · Hissink, E.M.
Keywords: Biology

5 Prediction of isoprene diepoxide levels in vivo in mouse, rat and man using enzyme kinetic data in vitro and physiologically-based pharmacokinetic modelling
article 2001    
Author: Bogaards, J.J.P. · Freidig, A.P. · Bladeren, P.J. van
Keywords: Nutrition
[Abstract]

6 Conjugation of isoprene monoepoxides with glutathione, catalyzed by alpha, mu, pie and teta-class glutathione S-transferases of rat and man
article 1999    
Author: Bogaards, J.J.P. · Venekamp, J.C. · Salmon, F.G.C. · Bladeren, P.J. van
Keywords: Chemistry · analyse · chromatografie

7 Conjugation of isoprene monoepoxides with glutathione, catalyzed by α, μ, π and θ-class glutathione S-transferases of rat and man
article 1999    
Author: Bogaards, J.J.P. · Venekamp, J.C. · Salmon, F.G.C. · Bladeren, P.J. van
Keywords: Nutrition · Glutathione S-transferase · Isoprene · Metabolism · Polymorphism · Cytochrome p450 · Epoxide · Epoxide hydrolase · Glutathione · Glutathione transferase · Isoprene · Conjugate · Conjugation · Controlled study · High performance liquid chromatography · Human · Liver · Liver metabolism · Mouse · Rat · Xenobiotic metabolism · Animals · Chromatography, High Pressure Liquid · Epoxy Compounds · Glutathione · Glutathione Transferase · Humans · Liver · Mice · Rats · Rats, Wistar · Species Specificity · Subcellular Fractions
[Abstract]

8 Hepatic epoxide concentrations during biotransformation of 1,2- and 1,4- dichlorobenzene: The use of in vitro and in vivo metabolism, kinetics and PB- PK modeling
article 1996    
Author: Hissink, E. · Ommen, B. van · Bogaards, J.J. · Bladeren, P.J. van
Keywords: Toxicology · 1,2 dichlorobenzene · 1,4 dichlorobenzene · alanine aminotransferase · ascorbic acid · cytochrome p450 isoenzyme · epoxide · glutathione · isoniazid · animal cell · animal experiment · animal model · biotransformation · conference paper · controlled study · detoxification · enzyme substrate · liver microsome · liver toxicity · male · mathematical model · nonhuman · priority journal · rat · toxicokinetics · Animals · Biotransformation · Carcinogens · Chlorobenzenes · Cytochrome P-450 Enzyme System · Epoxy Compounds · Humans · Liver · Male · Microsomes, Liver · Models, Biological · Rats · Rats, Wistar

9 Human cytochrome P450 enzyme selectivities in the oxidation of chlorinated benzenes
article 1995    
Author: Bogaards, J.J.P. · Ommen, B. van · Wolf, C.R. · Bladeren, P.J. van
Keywords: Toxicology · Cell Line · Chlorobenzenes · Chlorzoxazone · Chromatography, Gas · Cytochrome P-450 Enzyme System · Ethanolamines · Human · Oxazines · Oxidation-Reduction · Substrate Specificity · Testosterone · Transfection
[Abstract]

10 Inhibition of human glutathione S-transferases by curcumin and analogues
article 2009    
Author: Appiah-Opong, R. · Commandeur, J.N. · Istyastono, E. · Bogaards, J.J. · Vermeulen, N.P.
Keywords: Biology

11 Determining the best animal model for human cytochrome P450 activities : a comparison of mouse, rat, rabbit, dog, micropig, monkey and man
article 2000    
Author: Bogaards, J.J.P. · Bertrand, M. · Jackson, P. · Oudshoorn, M.J. · Weavers, R.J. · Bladeren, P.J. van · Walther, B.

12 Prediction of interindividual variation in drug plasma levels in vivo from individual enzyme kinetic data and physiologically based pharmacokinetic modeling
article 2000    
Author: Bogaards, J.J.P. · Hissink, E.M. · Briggs, M. · Weaver, R. · Jochemsen, R. · Jackson, P. · Bertrand, M. · Bladeren, P. van
Keywords: Nutrition · Cytochrome P450 · Interindividual variation · Metabolism · Physiologically based pharmacokinetic modeling · Agomelatine · Bufuralol · Chlorzoxazone · Coumarin · Cytochrome P450 · Diclofenac · Ethoxyresorufin · Mephenytoin · Testosterone · Clinical trial · Controlled clinical trial · Controlled study · Drug blood level · Enzyme kinetics · Food drug interaction · Genetic polymorphism · Human · Human cell · Human experiment · Human tissue · Liver microsome · Male · Model · Normal human · Phase 1 clinical trial · Phenotype · Priority journal · Acetamides · Cell Line · Cytochrome P-450 Enzyme System · Humans · Hypnotics and Sedatives · Isoenzymes · Kinetics · Microsomes, Liver · Models, Biological · Pharmaceutical Preparations · Pharmacokinetics · Recombinant Proteins · Transfection
[Abstract]

13 Computer-aided biokinetic modelling combined with in vitro data
article 1995    
Author: Ommen, B. van · Jongh, J. de · Sandt, J. van de · Blaauboer, B. · Hissink, E. · Bogaards, J. · Bladeren, P. van
Keywords: Toxicology · Animalia · Oryctolagus cuniculus · Sus scrofa
[Abstract]

14 Some principles of combination toxicology applied to defined mixtures of (chlorinated organic) chemicals
article 1995    
Author: Feron, V.J. · Jonker, D. · Berg, M. van den · Bogaards, J.J.P. · Groten, J.P. · Bladeren, P.J.
Keywords: Nutrition

15 Transcriptomics analysis of interactive effects of benzene, trichloroethylene and methyl mercury within binary and ternary mixtures on the liver and kidney following subchronic exposure in the rat
article 2007    
Author: Hendriksen, P.J.M. · Freidig, A.P. · Jonker, D. · Thissen, U. · Bogaards, J.J.P. · Mumtaz, M.M. · Groten, J.P. · Stierum, R.H.
Keywords: Biology · Analytical research · Biomedical research · Benzene · Mercury · Microarrays · Mixtures · Toxicogenomics · Trichloroethylene · benzene · biological marker · messenger RNA · methylmercury · trichloroethylene · animal experiment · animal tissue · apoptosis · article · Ccng1 gene · cell proliferation · cell viability · controlled study · gene · gene expression profiling · gene induction · id2 gene · liver toxicity · long term exposure · male · MDM2 gene · microarray analysis · nephrotoxicity · NFKB1 gene · nonhuman · Nr2f6 gene · rat · stress · tissue specificity · tnfrsf1a gene · toxicogenetics · transcriptomics · Animals · Benzene · Cell Survival · Drug Interactions · Drug Synergism · Environmental Pollutants · Gene Expression Profiling · Gene Expression Regulation · Kidney · Liver · Male · Methylmercury Compounds · No-Observed-Adverse-Effect Level · Oligonucleotide Array Sequence Analysis · Rats · Rats, Inbred F344 · RNA, Messenger · Toxicity Tests · Trichloroethylene · Rattus
[Abstract]

16 The use of in vitro metabolic parameters and physiologically based pharmacokinetic (PBPK) modeling to explore the risk assessment of trichloroethylene
article 2002    
Author: Hissink, E.M. · Bogaards, J.J.P. · Freidig, A.P. · Commandeur, J.N.M. · Vermeulen, N.P.E. · Bladeren, P.J. van
Keywords: Environment · PBPK · Radioactivity · Trichloroethylene
[Abstract]

17 Effect of short-term dietary administration of eugenol in humans
article 1996    
Author: Rompelberg, C.J.M. · Vogels, J.T.W.E. · Vogel, N. de · Bruijntjes-Rozier, G.C.D.M. · Stenhuis, W.H. · Bogaards, J.J.P. · Verhagen, H.
Keywords: Nutrition · Antigenotoxicity · Eugenol · GST · antitoxin · eugenol · glutathione transferase · mitomycin c · vinblastine · article · biotransformation · blood sampling · chromosome aberration · controlled study · enzyme activity · erythrocyte · genotoxicity · human · human experiment · leukocyte · male · micronucleus · priority journal · xenobiotic metabolism · Acetaminophen · Adult · Antibiotics, Antineoplastic · Antineoplastic Agents, Phytogenic · Biotransformation · Cells, Cultured · Chromosome Aberrations · Cross-Over Studies · Erythrocytes · Eugenol · Glutathione Transferase · Humans · Intervention Studies · Leukocytes · Liver · Magnetic Resonance Spectroscopy · Male · Mitomycin · Vinblastine
[Abstract]

18 Effect of a vegan diet on biomarkers of chemoprevention in females
article 1996    
Author: Verhagen, H. · Rauma, A.L. · Törrönen, R. · Vogel, N. de · Bruijntjes-Rozier, G.C.D.M. · Dreve, M.A. · Bogaards, J.J.P. · Mykkänen, H.
Keywords: Nutrition · Adult · Aged · Aging · Antibiotics, Antineoplastic · Cells, Cultured · Chemoprevention · Cross-Sectional Studies · Diet, Vegetarian · DNA Damage · DNA, Single-Stranded · Electrophoresis · Erythrocytes · Female · Glutathione Transferase · Humans · Leukocytes · Micronuclei, Chromosome-Defective · Middle Aged · Mitomycin · Superoxide Dismutase
[Abstract]

19 Human cytochrome P450 enzyme specificity for the bioactivation of estragole and related alkenylbenzenes
article 2007    
Author: Jeurissen, S.M.F. · Punt, A. · Boersma, M.G. · Bogaards, J.J.P. · Fiamegos, Y.C. · Schilter, B. · Bladeren, P.J. van · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · 1' hydroxyestragole · alkenylbenzene derivative · alpha naphthoflavone · benzene derivative · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2C19 · cytochrome P450 2D6 · cytochrome P450 2E1 · estragole · methyleugenol · safrole · article · enzyme specificity · human · human cell · hydroxylation · liver microsome · phenotype · protein expression · Anisoles · Biotransformation · Chromatography, High Pressure Liquid · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Eugenol · Flavoring Agents · Humans · Hydroxylation · Microsomes, Liver · Safrole · Substrate Specificity
[Abstract]

20 Human cytochrome P450 enzyme specificity for bioactivation of safrole to the proximate carcinogen 1′-hydroxysafrole
article 2004    
Author: Jeurissen, S.M.F. · Bogaards, J.J.P. · Awad, H.M. · Boersma, M.G. · Brand, W. · Fiamegos, Y.C. · Beek, T.A. van · Alink, G.M. · Sudhölter, E.J.R. · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Physiological Sciences · 1' hydroxysafrole · carcinogen · cytochrome P450 · cytochrome P450 2A6 · cytochrome P450 2C9 · cytochrome P450 2D6 · cytochrome P450 2E1 · safrole · unclassified drug · animal cell · article · enzyme activation · enzyme specificity · human · insect cell · microsome · nonhuman · reaction analysis · Biotransformation · Carcinogens · Cytochrome P-450 Enzyme System · Humans · Microsomes, Liver · Risk Assessment · Safrole · Statistics, Nonparametric · Substrate Specificity · Animalia · Insecta
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 22 found. Next | Sort by date