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Showing 1 to 13 of 13 found. | Sort by date

1 Bioinformatics Methods for Interpreting Toxicogenomics Data: The Role of Text-Mining
bookPart 2014    
Author: Hettne, K.M. · Kleinjans, J. · Stierum, R.H. · Boorsma, A. · Kors, J.A.
Keywords: Biology · Bioinformatics · Gene-expression profiling · Gene-set analysis · Text-mining · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

2 Transcriptome analysis of sorbic acid-stressed Bacillus subtilis reveals a nutrient limitation response and indicates plasma membrane remodeling
article 2008    
Author: Beek, A. ter · Keijser, B.J.F. · Boorsma, A. · Zakrzewska, A. · Orij, R. · Smits, G.J. · Brul, S.
Keywords: Biology · Biotechnology · cerulenin · sorbic acid · tricarboxylic acid · acidity · article · Bacillus subtilis · bacterial gene · bacterial genome · bacterial growth · bkdr regulated gene · ccpa gene · cell membrane · codY gene · fag bene · fur gene · genetic transcription · growth inhibition · nonhuman · nutrient limitation · priority journal · regulon · sigh mediated gene · sigl mediated gene · sporogenesis · transcriptomics · upregulation · Anions · Bacillus subtilis · Bacterial Proteins · Cell Membrane · Cerulenin · Gene Expression Profiling · Gene Expression Regulation, Bacterial · Hydrogen-Ion Concentration · Oligonucleotide Array Sequence Analysis · Regulon · Reverse Transcriptase Polymerase Chain Reaction · Sorbic Acid · Bacillus subtilis
[Abstract]

3 Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds
article 2010    
Author: Briel, R.J. van de · Pennings, J.L.A. · Baken, K.A. · Pronk, T.E. · Boorsma, A. · Gottschalk, R. · Loveren, H. van
Keywords: Biology · Biomedical Research · Gene profiling · HaCaT · Irritant oxidative stress · Keratinocytes · Sensitizer · 1 chloro 2,4 dinitrobenzene · 2 propanol · benzoic acid · cinnamyl alcohol · collagen type 16 · disulfiram · dodecyl sulfate sodium · eugenol · ferritin · ferrochelatase · glucose 6 phosphate dehydrogenase · glucuronosyltransferase 1A6 · glutamate cysteine ligase · glutathione reductase · heat shock protein · heme oxygenase 1 · hexane · interleukin 6 receptor · irritant agent · isoeugenol · lactic acid · mitogen activated protein kinase · nickel sulfate · phosphogluconate dehydrogenase · salicylic acid methyl ester · thioredoxin 2 · thioredoxin reductase 1 · thioredoxin reductase 2 · transcription factor Nrf2 · article · cell viability · gene control · gene expression profiling · human · human cell · human cell culture · in vitro study · keratinocyte · oxidative stress · random forest · sensitization · support vector machine
[Abstract]

4 Time series analysis of benzo[a]pyrene-induced transcriptome changes suggests that a network of transcription factors regulates the effects on functional gene sets
article 2010    
Author: Delft, J.H.M. van · Mathijs, K. · Staal, Y.C.M. · Herwijnen, M.H.M. van · Brauers, K.J.J. · Boorsma, A. · Kleinjans, J.C.S.
Keywords: Nutrition · Biomedical Research · Carcinogen · Network · Time series · Transcription factor · Transcriptome · benzo[a]pyrene · immunoglobulin enhancer binding protein · Myc protein · serum response factor · transcription factor · transcription factor AP 1 · transcription factor E2F1 · transcriptome · amino acid metabolism · apoptosis · article · carcinogenesis · cell cycle G1 phase · cell cycle S phase · controlled study · correlation analysis · DNA adduct · DNA repair · down regulation · functional genomics · gene expression · gene regulatory network · hepatoma cell · human · human cell · lipid metabolism · named inventories, questionnaires and rating scales · proto oncogene · Short Time series Expression Miner · signal transduction · time series analysis · transcription regulation · tumor suppressor gene · upregulation
[Abstract]

5 Comparative analysis of transcriptome and fitness profiles reveals general and condition-specific cellular functions involved in adaptation to environmental change in Saccharomyces cerevisiae
article 2010    
Author: Zakrzewska, A. · Boorsma, A. · Beek, A.T. · Hageman, J.A. · Westerhuis, J.A. · Hellingwerf, K.J. · Brul, S. · Klis, F.M. · Smits, G.J.
Keywords: Health · Biomedical Research · actin · transcriptome · adaptation · article · biogenesis · cell function · cell polarity · cytoskeleton · environmental stress · fungal genome · gene cluster · gene deletion · genetic transcription · nonhuman · nutrient availability · oxidative stress · phenotype · priority journal · ribosome · Saccharomyces cerevisiae · yeast cell
[Abstract]

6 The contact allergen dinitrochlorobenzene (DNCB) and respiratory allergy in the Th2-prone Brown Norway rat
article 2008    
Author: Kuper, C.F. · Stierum, R.H. · Boorsma, A. · Schijf, M.A. · Prinsen, M. · Bruijntjes, J.P. · Bloksma, N. · Arts, J.H.E.
Keywords: Health · Dinitrochlorobenzene · LLNA · MCP-1 · MIP1-beta · Respiratory allergy · Skin allergy · 1 chloro 2,4 dinitrobenzene · CD4 antigen · immunoglobulin G · macrophage inflammatory protein 1beta · monocyte chemotactic protein 1 · monocyte chemotactic protein 3 · thymus and activation regulated chemokine · animal experiment · animal model · animal tissue · article · controlled study · female · lung function · lung lavage · lung parenchyma · male · microarray analysis · nonhuman · Norway · nucleotide sequence · priority journal · rat · respiratory tract allergy · skin allergy · skin irritation · skin sensitization · Th2 cell · upregulation · Administration, Cutaneous · Allergens · Animals · Dermatitis, Allergic Contact · Dinitrochlorobenzene · Female · Immunoglobulin E · Immunoglobulin G · Inhalation Exposure · Irritants · Local Lymph Node Assay · Lung · Lymph Nodes · Male · Rats · Rats, Inbred BN · Rats, Wistar · Respiratory Function Tests · Respiratory Hypersensitivity · Th2 Cells · Animalia · Rattus · Rattus norvegicus
[Abstract]

7 Molecular characterization of trimellitic anhydride-induced respiratory allergy in Brown Norway rats
article 2008    
Author: Kuper, C.F. · Heijne, W.H. · Dansen, M. · Verhoeckx, K.C. · Boorsma, A. · Radonjic, M. · Bruijntjes, J. · Stierum, R. · Muijser, H. · Arts, J.H.
Keywords: Biology · Toxicology and Applied Pharmacology · Allergen · Immunoglobulin E · Phthalic anhydride · Toll like receptor · Trimellitic anhydride · Analysis of variance · Animal · Article · Blood · Brown Norway rat · Cluster analysis · DNA microarray · Drug effect · Female · Gene expression profiling · Genetics · Immunohistochemistry · Lung · Lung lavage · Metabolism · Nonparametric test · Pathology · Principal component analysis · Proteomics · Rat · Respiratory tract allergy · Signal transduction · Allergens · Analysis of Variance · Animals · Bronchoalveolar Lavage · Cluster Analysis · Female · Gene Expression Profiling · Immunoglobulin E · Immunohistochemistry · Lung · Oligonucleotide Array Sequence Analysis · Phthalic Anhydrides · Principal Component Analysis · Proteomics · Rats · Rats, Inbred BN · Respiratory Hypersensitivity · Signal Transduction · Statistics, Nonparametric · Toll-Like Receptors
[Abstract]

8 Detection of the mechanism of immunotoxicity of cyclosporine A in murine in vitro and in vivo models
article 2015    
Author: Schmeits, P.C.J. · Schaap, M.M. · Luijten, M. · Someren, E. van · Boorsma, A. · Loveren, H. van · Peijnenburg, A.A.C.M. · Hendriksen, P.J.M.
Keywords: Biology · C57BL/6 · CTLL-2 · Cyclosporine A · Interspecies comparison · Splenocytes · Interleukin 2 · Messenger RNA · Transcription factor Nrf2 · Animal cell · Animal experiment · Cell cycle regulation · Controlled study · Cytotoxic T lymphocyte · Down regulation · Endoplasmic reticulum stress · HepG2 cell line · Human · Human cell · Immune response · Immunotoxicity · In vitro study · In vivo study · Jurkat cell line · Male · Mouse · Nonhuman · Dpleen cell · T lymphocyte activation · Thymoma cell line · Transcriptomics · Unfolded protein response · Upregulation · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

9 Parallelogram approach using rat-human In vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans
article 2009    
Author: Kienhuis, A.S. · Poll, M.C.G. van de · Wortelboer, H. · Herwijnen, M. van · Gottschalk, R. · Jong, C.H.C. de · Boorsma, A. · Paules, R.S. · Kleinjans, J.C.S. · Stierum, R.H. · Delft, J.H.M. van
Keywords: Toxicology · Biotechnology · Acetaminophen · Gene expression profiling · Hepatocyte-based in vitro models · Interspecies extrapolation · Liver injury · T-profiler · oxidoreductase · paracetamol · adult · aged · animal cell · animal experiment · animal model · animal tissue · article · biological activity · cell function · chemical analysis · controlled study · energy consumption · enzyme activity · female · gene expression profiling · gene repression · human · human cell · human tissue · human versus animal comparison · in vitro study · in vivo study · liver cell · liver metabolism · liver mitochondrion · liver toxicity · male · nonhuman · rat · species comparison · toxicogenetics · Acetaminophen · Adult · Aged · Analgesics, Non-Narcotic · Animals · Cell Survival · Cells, Cultured · Female · Hepatitis, Toxic · Hepatocytes · Humans · In Situ Hybridization · Male · Predictive Value of Tests · Rats · Rats, Inbred F344 · Rats, Wistar · RNA · Species Specificity · Toxicogenetics · Rattus · Rodentia
[Abstract]

10 A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo
article 2009    
Author: Kienhuis, A.S. · Poll, M.C.G. van de · Jong, C.H.C. de · Gottschalk, R. · Herwijnen, M. van · Boorsma, A. · Kleinjans, J.C.S. · Stierum, R.H. · Delft, J.H.M. van
Keywords: Biology · Biomedical Research · Coumarin · Gene expression profiling · Hepatotoxicity · Parallelogram approach · Primary human hepatocytes · Species difference · Toxicogenomics · Coumarin · Adult · Aged · Blood clotting · Concentration response · Controlled study · Disorders of mitochondrial functions · Down regulation · Energy consumption · Female · Gene expression profiling · Genomics · Human · Human cell · Liver cell · Liver toxicity · Male · Species difference · Toxicogenetics · Transcriptomics · Animalia · Rattus
[Abstract]

11 Systems biology of personalized nutrition
article 2017    
Author: Ommen, B. van · Broek, T. van den · Hoogh, I. de · Erk, M. van · Someren, E. van · Rouhani-Rankouhi, T. · Anthony, J.C. · Hogenelst, K. · Pasman, W. · Boorsma, A. · Wopereis, S.
Keywords: Nutrition · Flexibility · Nutrigenetics · Nutrigenomics · Personalized nutrition · Systems biology · Biological marker · Trace element · Biological activity · Chronobiology · Clinical practice · Diet restriction · Genetic variation · Genetics · Homeostasis · Human · Inflammation · Knowledge · Macronutrient · Metabolism · Nonhuman · Nutrition · Physical activity · phytonutrient · Satiety · Stress · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

12 Beneficial effect of personalized lifestyle advice compared to generic advice on wellbeing among Dutch seniors – An explorative study
article 2019    
Author: Doets, E.L. · Hoogh, I.M. de · Holthuysen, N. · Wopereis, S. · Verain, M.C.D. · Puttelaar, J. van den · Hogenelst, K. · Boorsma, A. · Bouwman, E.P. · Timmer, M. · Pasman, W.J. · Erk, M. van · Reinders, M.J.
Keywords: Personalized nutrition · Older adults · Web-based feedback · Lifestyle behavior · Muscle health · Wellbeing
[PDF] [Abstract]

13 Genomic analysis suggests higher susceptibility of children to air pollution
article 2008    
Author: Leeuwen, D.M. van · Pedersen, M. · Hendriksen, P.J.M. · Boorsma, A. · Herwijnen, M.H.M. van · Gottschalk, R.W.H. · Kirsch-Volders, M. · Knudsen, L.E. · Šrám, R.J. · Bajak, E. · Delft, J.H.M. van · Kleinjans, J.C.S.
Keywords: Health · Physiological Sciences · transcriptome · adult · air pollution · article · blood analysis · cancer risk · cancer susceptibility · child · child health · controlled study · Czech Republic · data analysis · environmental exposure · environmental health · female · gene expression · gene expression profiling · genomics · human · immune response · male · micronucleus · nucleosome · parent · priority journal · Adult · Air Pollution · Child · Czech Republic · Female · Gene Expression Profiling · Gene Expression Regulation · Genetic Predisposition to Disease · Humans · Male · Nuclear Family · Parents · Receptors, Chemokine · RNA · RNA Splicing
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 13 of 13 found. | Sort by date