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1 Quantitative structure activity relationships for the biotransormation and toxicity of halogenated benzene-derivatives : implications for enzyme catalysis and reaction mechanisms
dissertation 1996    
Author: Cnubben, N.H.P.
Keywords: Nutrition · Medicine · Geneeskunde · Physiology · Fysiologie · Food and Nutrition · Healthy Living
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2 Quantitative analysis of Tenecteplase in rat plasma samples using LC-MS/MS as an alternative for ELISA
article 2007    
Author: Buscher, B.A.P. · Gerritsen, H. · Schöll, I. van · Cnubben, N.H.P. · Brüll, L.P.
Keywords: Biology · Analytical research · Digestion · Liquid chromatography · Mass spectrometry · Plasma · Proteins · Quantitative analysis · Blood · Digestive system · Drug products · Enzymes · Sensitivity analysis · Internal standard · Tenecteplase · Trypsin · Chemical analysis · tenecteplase · animal experiment · article · blood sampling · controlled study · drug distribution · enzyme linked immunosorbent assay · liquid chromatography · mass spectrometry · nonhuman · priority journal · quantitative analysis · rat · single drug dose · Animals · Chromatography, Liquid · Enzyme-Linked Immunosorbent Assay · Fibrinolytic Agents · Rats · Sensitivity and Specificity · Tandem Mass Spectrometry · Tissue Plasminogen Activator · Rattus
[Abstract]

3 Transport of the glutathione conjugate of ethacrynic acid by the human multidrug resistance protein MRP
article 1996    
Author: Zaman, G.J.R. · Cnubben, N.H.P. · Bladeren, P.J. van · Evers, R. · Borst, P.
Keywords: Adenosine Monophosphate · ATP-Binding Cassette Transporters · Biological Transport · Carcinoma, Non-Small-Cell Lung · Cell Membrane · Drug Resistance, Multiple · Ethacrynic Acid · Glutathione · Humans · Kinetics · Lung Neoplasms · Multidrug Resistance-Associated Proteins · Recombinant Proteins · Saccharomyces cerevisiae · Sulfinpyrazone · Transfection · Tumor Cells, Cultured
[PDF] [Abstract]

4 Glutathione-dependent biotransformation of the alkylating drug thiotepa and transport of its metabolite monoglutathionylthiotepa in human MCF-7 breast cancer cells
article 1998    
Author: Cnubben, N.H.P. · Rommens, A.J.M. · Oudshoorn, M.J. · Bladeren, P.J. van
Keywords: Nutrition

5 Modelling the responses to biological reactive intermediates : establishing the borderlines of risk
article 2001    
Author: Bladeren, P.J. van · Bogaards, J.J.P. · Cnubben, N.H.P. · Hissink, E.M.
Keywords: Biology

6 Comparative in vitro-in vivo percutaneous penetration of the fungicide ortho-phenylphenol
article 2002    
Author: Cnubben, N.H.P. · Elliott, G.R. · Hakkert, B.C. · Meuling, W.J.A. · Sandt, J.J.M. van de
Keywords: Health · Dermal penetration · In vitro-in vivo comparison · Ortho-phenylphenol · Risk assessment · 2 hydroxybiphenyl · 2-phenylphenol · Biphenyl derivative · Fungicide · Animal tissue · Biotransformation · Controlled study · Human · Human tissue · In vitro study · In vivo study · Male · Nonhuman · Skin absorption · Skin culture · Skin penetration · Thickness · Toxicokinetics · Urinary excretion · Adult · Animal · Comparative study · Dose response · Epidermis · Intradermal drug administration · Membrane · Metabolism · Outbred strain · Permeability · Swine · Wistar rat · Administration, Cutaneous · Adult · Animal · Animals, Outbred Strains · Biphenyl Compounds · Comparative Study · Dose-Response Relationship, Drug · Epidermis · Female · Fungicides, Industrial · Human · In Vitro · Male · Membranes · Permeability · Rats · Rats, Wistar · Skin Absorption · Support, Non-U.S. Gov't · Swine · Animals · Humans · Sus scrofa
[Abstract]

7 Comparative in vitro-in vivo percutaneous absorption of the pesticide propoxur
article 2000    
Author: Sandt, J.J.M. van de · Meuling, W.J.A. · Elliott, G.R. · Cnubben, N.H.P. · Hakkert, B.C.
Keywords: Nutrition · Human · In vitro/in vivo comparisons · Perfused-pig-ear model · Propoxur · Rat · Viable skin and epidermal membranes · Carbon 14 · Pesticide · Propoxur · Animal model · Animal tissue · Blood sampling · Ear · Environmental exposure · Epidermis · Human · Human experiment · Human tissue · Isotope labeling · Nonhuman · Normal human · Pest control · Rat · Skin absorption · Swine · Urinalysis · Animal Testing Alternatives · Animals · Ear, External · Epidermis · Humans · Insecticides · Male · Models, Animal · Perfusion · Propoxur · Rats · Rats, Wistar · Skin Absorption · Species Specificity · Swine · Animalia · Sus scrofa
[Abstract]

8 Glutathione-dependent interaction of heavy metal compounds with multidrug resistance proteins MRP1 and MRP2
article 2008    
Author: Wortelboer, H.M. · Balvers, M.G.J. · Usta, M. · Bladeren, P.J. van · Cnubben, N.H.P.
Keywords: Health · Physiological Sciences · Arsenic trioxide · Cisplatin · Glutathione · Mercury chloride · MRP1 · MRP2 · Adenosine triphosphatase · Calcein · Cisplatin · Glutathione · Multidrug resistance protein 1 · Multidrug resistance protein 2 · Animal cell · Cell viability · Complex formation · Controlled study · Enzyme activity · Kidney cell · Membrane vesicle · Molecular interaction · Nonhuman · Protein expression · Transport kinetics
[Abstract]

9 Interactions of prostaglandin A2 with the glutathione-mediated biotransformation system
article 1999    
Author: Iersel, M.L.P.S. van · Cnubben, N.H.P. · Smink, N. · Koeman, J.H. · Bladeren, P.J. van
Keywords: Nutrition · Cells · Glutathione S-transferases · Inhibition · Metabolism · Prostaglandin A2 · 1 chloro 2,4 dinitrobenzene · Glutathione · Glutathione transferase · Prostaglandin a2 · Glutathione transferase P1 · GSTP1 protein, human · Isoenzyme · Prostaglandin A · Prostaglandin A2 · Biotransformation · Cell function · Cell metabolism · Cell proliferation · Controlled study · Cytotoxicity · Enzyme activity · Enzyme modification · Human · Human cell · Melanoma cell · Priority journal · Cell culture · Drug antagonism · Melanoma · Metabolism · Biotransformation · Glutathione · Glutathione S-Transferase pi · Glutathione Transferase · Humans · Isoenzymes · Melanoma · Prostaglandins A · Tumor Cells, Cultured
[Abstract]

10 Transport of glutathione A conjugates by the multifrug resistance protein 1
article 1997    
Author: Evers, R. · Cnubben, N.H.P. · Wijnholds, J. · Deemter, L. van · Bladeren, P.J. van · Borst, P.
Keywords: GS-X pump · Multidrug resistance · Adenosine Triphosphate · Animals · Biological Transport · Cell Line · Cell Polarity · Cyclic AMP · Dogs · Erythrocytes · Ethacrynic Acid · Glutathione · Humans · Kidney · Methotrexate · Mice · Mice, Mutant Strains · Microsomes · P-Glycoprotein · Prostaglandins A, Synthetic · Stereoisomerism
[PDF] [Abstract]

11 Interactions of prostaglandin A2 with the glutathione-mediated biotransformation system
article 1999    
Author: Iersel, M.L.P.S. van · Cnubben, N.H.P. · Smink, N. · Koeman, J.H. · Bladeren, P.J. van

12 The interplay of glutathione-related processes in antioxidant defense
article 2001    
Author: Cnubben, N.H.P. · Rietjens, I.M.C.M. · Wortelboer, H. · Zanden, J.J. van · Bladeren, P.J. van
Keywords: Environment · Antioxidant · Glutathione · Glutathione S-transferases · Multidrug resistance associated protein · Oxidative stress
[Abstract]

13 An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: A nutrigenomics approach
article 2010    
Author: Bakker, G.C.M. · Erk, M.J. van · Pellis, L. · Wopereis, S. · Rubingh, C.M. · Cnubben, N.H.P. · Kooistra, T. · Ommen, B. van · Hendriks, H.F.J.
Keywords: Biology · Physiological Sciences · adiponectin · antiinflammatory agent · antioxidant · C reactive protein · adipose tissue · adult · article · blood · clinical trial · controlled clinical trial · controlled study · crossover procedure · diet · diet therapy · double blind procedure · drug effect · female · human · inflammation · lipid metabolism · liver · male · metabolic disorder · metabolism · methodology · middle aged · mononuclear cell · nutrigenomics · obesity · oxidative stress · pathophysiology · randomized controlled trial · vascular endothelium · Adiponectin · Adipose Tissue · Adult · Anti-Inflammatory Agents · Antioxidants · C-Reactive Protein · Cross-Over Studies · Diet · Double-Blind Method · Endothelium, Vascular · Female · Humans · Inflammation · Leukocytes, Mononuclear · Lipid Metabolism · Liver · Male · Metabolic Diseases · Middle Aged · Nutrigenomics · Overweight · Oxidative Stress · Young Adult
[Abstract]

14 The effect of quercetin phase II metabolism on its MRP1 and MRP2 inhibiting potential
article 2007    
Author: Zanden, J.J. van · Woude, H. van der · Vaessen, J. · Usta, M. · Wortelboer, H.M. · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biomedical Research · ABC transporters · Flavonoids · MRP1 · MRP2 · Phase II metabolism · Quercetin · ABC transporter · flavonoid · multidrug resistance protein 1 · multidrug resistance protein 2 · quercetin · animal cell · article · cancer cell culture · cancer chemotherapy · chemical structure · controlled study · enzyme activity · enzyme inhibition · glucuronidation · human · human cell · multidrug resistance · nonhuman · priority journal · rat · Animals · Cell Line, Tumor · Humans · Membrane Transport Proteins · Multidrug Resistance-Associated Proteins · Quercetin · Rats
[Abstract]

15 Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients
article 2006    
Author: Brand, W. · Schutte, M.E. · Williamson, G. · Zanden, J.J. van · Cnubben, N.H.P. · Groten, J.P. · Bladeren, P.J. van · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · ATP binding cassette (ABC) transport proteins · Flavonoids · Intestinal transcellular transport · Animals · ATP-Binding Cassette Transporters · Biological Availability · Biological Transport · Drug Resistance, Multiple · Flavonoids · Humans · Intestines
[Abstract]

16 Inhibition of multidrug resistance proteins MRP1 and MRP2 by a series of α,β-unsaturated carbonyl compounds
article 2005    
Author: Wortelboer, H.M. · Usta, M. · Zanden, J.J. van · Bladeren, P.J. van · Rietjens, I.M.C.M. · Cnubben, N.H.P.
Keywords: Nutrition · Biomedical Research · α,β-Unsaturated carbonyl compounds · Inhibition · MRP1 · MRP2 · 2 hexenal · acrolein · caffeic acid phenethyl ester · calcein · carbonyl derivative · cinnamaldehyde · citral · crotonaldehyde · curcumin · cyclosporin A · demethoxycurcumin · didemethoxycurcumin · drug metabolite · glutathione · multidrug resistance protein 1 · multidrug resistance protein 2 · thiol derivative · unclassified drug · verlukast · animal cell · article · cell isolation · cell metabolism · conjugate · controlled study · dog · drug efficacy · drug metabolism · drug potency · drug protein binding · glutathione metabolism · kidney cell · membrane vesicle · modulation · molecular model · molecular stability · nonhuman · priority journal · protein expression · protein transport · Aldehydes · Animals · Biological Transport · Cell Line · Curcumin · Dogs · Fluoresceins · Humans · Membrane Transport Modulators · Membrane Transport Proteins · Multidrug Resistance-Associated Proteins · Transfection
[Abstract]

17 Reversal of in vitro cellular MRP1 and MRP2 mediated vincristine resistance by the flavonoid myricetin
article 2005    
Author: Zanden, J.J. van · Mul, A. de · Wortelboer, H.M. · Usta, M. · Bladeren, P.J. van · Rietjens, I.M.C.M. · Cnubben, N.H.P.
Keywords: Biology · Physiological Sciences · Flavonoids · MRP1 · MRP2 · Multidrug resistance · Myricetin · Vincristine · antineoplastic agent · flavonoid · multidrug resistance protein 1 · multidrug resistance protein 2 · myricetin · vincristine · animal cell · article · cell line · cell proliferation · chemotherapy · concentration (parameters) · controlled study · drug resistance · drug transport · genetic transfection · IC 50 · in vitro study · nonhuman · priority journal · Animals · Cell Line · Cell Proliferation · Dogs · Dose-Response Relationship, Drug · Drug Resistance, Neoplasm · Flavonoids · Humans · Membrane Transport Modulators · Membrane Transport Proteins · Multidrug Resistance-Associated Proteins · Vincristine
[Abstract]

18 Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2
article 2005    
Author: Zanden, J.J. van · Wortelboer, H.M. · Bijlsma, S. · Punt, A. · Usta, M. · Bladeren, P.J.V. · Rietjens, I.M.C.M. · Cnubben, N.H.P.
Keywords: Nutrition Pharmacology · Analytical research · Calcein · Flavonoids · MRP1 · MRP2 · QSAR · 3 hydroxyflavone · 3' hydroxyflavone · 3',4' dihydroxyflavone · 3,3' dihydroxyflavone · 3,3',4' trihydroxyflavone · 4' hydroxyflavone · 5,7,3',4' tetramethoxyflavone · acacetin · apigenin · baicalein · catechin · chrysin · fisetin · flavone · flavonoid · galangin · kaempferide · kaempferol · luteolin · morin · multidrug resistance protein 1 · multidrug resistance protein 2 · myricetin · naringenin · protein inhibitor · quercetin · robinetin · taxifolin · unclassified drug · unindexed drug · valspodar · verlukast · animal cell · article · cell kinetics · cell transport · controlled study · drug effect · drug inhibition · drug potency · drug selectivity · genetic transfection · IC 50 · nonhuman · priority journal · protein analysis · quantitative structure activity relation · Animals · Cell Line · Dogs · Flavonoids · Fluoresceins · Membrane Transport Modulators · Membrane Transport Proteins · Multidrug Resistance-Associated Proteins · Quantitative Structure-Activity Relationship
[Abstract]

19 Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells
article 2004    
Author: Zanden, J.J. van · Geraets, L. · Wortelboer, H.M. · Bladeren, P.J. van · Rietjens, I.M.C.M. · Cnubben, N.H.P.
Keywords: Biology Toxicology · Physiological Sciences · 1-chloro-2,4-dinitrobenzene · 50% inhibition concentration · CDNB · DNP-SG · Glutathione · Glutathione conjugate · Glutathione S-transferase · GS-X · GSH · GST · IC50 · MRP · Multidrug resistance associated protein · P-gp · S-(2,4-dinitrophenyl)glutathione · 3',4' dihydroxyflavone · carbon · catechin · catechol derivative · eriodictyol · flavanoid · flavone derivative · galanin · glutathione transferase · hydroxyl group · kaempferol · luteolin · morin · multidrug resistance protein 1 · multidrug resistance protein 2 · myricetin · quercetin · taxifolin · unclassified drug · animal cell · article · breast cancer · cell strain MCF 7 · chemical bond · controlled study · drug activity · drug potency · enzyme activity · enzyme inhibition · genetic transfection · human · human cell · IC 50 · lipophilicity · nonhuman · priority journal · structure activity relation · toxicokinetics · Biological Transport · Breast Neoplasms · Carrier Proteins · Drug Resistance, Multiple · Drug Resistance, Neoplasm · Flavonoids · Glutathione · Glutathione S-Transferase pi · Glutathione Transferase · Humans · Isoenzymes · Membrane Transport Modulators · Membrane Transport Proteins · Multidrug Resistance-Associated Proteins · Structure-Activity Relationship · Tumor Cells, Cultured
[Abstract]

20 Human glutathione S-transferase-mediated glutathione conjugation of curcumin and efflux of these conjugates in caco-2 cells
article 2007    
Author: Usta, M. · Wortelboer, H.M. · Vervoort, J. · Boersma, M.G. · Rietjens, I.M.C.M. · Bladeren, P.J. van · Cnubben, N.H.P.
Keywords: Biology · Toxicology and Applied Pharmacology · curcumin · glutathione transferase · adult · aged · article · atom · catalysis · cell strain CACO 2 · conjugate · drug degradation · drug excretion · drug structure · female · glutathione metabolism · human · human cell · human tissue · intestine · intestine epithelium cell · liquid chromatography · liver cytosol · male · mass spectrometry · monolayer culture · proton nuclear magnetic resonance · Adult · Aged · Caco-2 Cells · Curcumin · Cytosol · Female · Glutathione · Glutathione Transferase · Humans · Intestines · Liver · Magnetic Resonance Spectroscopy · Male · Metabolic Detoxication, Phase II · Middle Aged · Molecular Structure
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 35 found. Next | Sort by date