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Showing 1 to 11 of 11 found. | Sort by date

1 Characterization of human cytochrome P450s involved in the bioactivation of tri-Ortho-Cresyl phosphate (ToCP)
article 2015    
Author: Reinen, J. · Nematollahi, L. · Fidder, A. · Vermeulen, N.P.E. · Noort, D. · Commandeur, J.N.M.
Keywords: Toxicology · Cytochrome P450 1A2 · Cytochrome P450 2C18 · Cytochrome P450 2D6 · Cytochrome P450 3A4 · Cytochrome P450 3A5 · Organophosphorus compound · Unclassified drug · Animal cell · Biotransformation · Cholinesterase inhibition · Controlled study · Enzyme inactivation · Humans · human cell · Hydrolysis · IC50 · In vitro study · Liver microsome · Liver microsome metabolism · Neurotoxicity · Nonhuman · Rats · Acetylcholinesterase, 9000-81-1 · Cholinesterase, 9001-08-5 · cytochrome P450, 9035-51-2 · Cytochrome P450 3A4, 329736-03-0 · Cytochrome P450 3A5, 336874-97-6 · Tri ortho cresyl phosphate, 78-30-8 · Observation, Weapon & Protection Systems · CBRN - CBRN Protection · TS - Technical Sciences
[Abstract]

2 Liquid chromatography/tandem mass spectrometry detection of covalent binding of acetaminophen to human serum albumin
article 2007    
Author: Damsten, M.C. · Commandeur, J.N.M. · Fidder, A. · Hulst, A.G. · Touw, D. · Noort, D. · Vermeulen, N.P.E.
Keywords: Cytochrome P450 · Paracetamol · Serum albumin · Article · Biological monitoring · Covalent bond · Drug protein binding · Human · Liquid chromatography · Microsome · Priority journal · Tandem mass spectrometry · Acetaminophen · Acetylcysteine · Animals · Benzoquinones · Chromatography, Liquid · Cysteine · Humans · Imines · Microsomes, Liver · Models, Biological · Molecular Structure · Oligopeptides · Protein Binding · Rats · Reproducibility of Results · Serum Albumin · Tandem Mass Spectrometry · Chemicals · CAS: cytochrome P450, 9035-51-2 · Paracetamol, 103-90-2 · Serum albumin, 9048-46-8 · Acetaminophen, 103-90-2 · Acetylcysteine, 616-91-1 · Benzoquinones · Cysteine, 52-90-4 · Imines · N-acetyl-4-benzoquinoneimine, 50700-49-7 · Oligopeptides
[Abstract]

3 Characterization of biotransformation enzyme activities in primary rat proximal tubular cells
article 2001    
Author: Schaaf, G.J. · Groene, E.M. de · Maas, R.F. · Commandeur, J.N.M. · Fink-Gremmels, J.
Keywords: Nutrition

4 Disposition of 1,2-[14C]dibromoethane in male wistar rats
article 1998    
Author: Wormhoudt, L.W. · Hissink, A.M. · Commandeur, J.N.M. · Bladeren, P.J. van · Vermeulen, N.P.E.
Keywords: Nutrition

5 Metabolism and kinetics of trichloroethylene in relation to toxicity and carcinogenicity : relevance of the mercapturic acid pathway
article 1995    
Author: Goeptar, A.R. · Commandeur, J.N.M. · Ommen, B. van · Bladeren, P.J. van · Vermeulen, N.P.E.
Keywords: Toxicology

6 In vitro inhibition of rat and human glutathione S-transferase isoenzymes by disulfiram and diethyldithiocarbamate
article 1996    
Author: Ploemen, J.-P.H.T.M. · Iersel, M.L.P.S. van · Wormhoudt, L.W. · Commandeur, J.N.M. · Vermeulen, N.P.E. · Bladeren, P.J. van
Keywords: diethyldithiocarbamate · disulfiram · gl utathion e · glutathione S-transferases · in vitro · inhibition · 1 chloro 2,4 dinitrobenzene · 1,2 epoxy 3 (4 nitrophenoxy)propane · aldehyde dehydrogenase inhibitor · diethyldithiocarbamic acid · disulfiram · dithiothreitol · glutathione transferase · isoenzyme · thiol · unclassified drug · article · controlled study · drug metabolism · enzyme inactivation · enzyme inhibition · enzyme purification · enzyme substrate · human · nonhuman · priority journal · rat · reduction · Animals · Disulfiram · Dithiothreitol · Ditiocarb · Glutathione · Glutathione Transferase · Humans · Isoenzymes · Rats · Spectrophotometry, Ultraviolet · Time Factors
[Abstract]

7 The use of in vitro metabolic parameters and physiologically based pharmacokinetic (PBPK) modeling to explore the risk assessment of trichloroethylene
article 2002    
Author: Hissink, E.M. · Bogaards, J.J.P. · Freidig, A.P. · Commandeur, J.N.M. · Vermeulen, N.P.E. · Bladeren, P.J. van
Keywords: Environment · PBPK · Radioactivity · Trichloroethylene
[Abstract]

8 A physiologically-based pharmacokinetic (PB-PK) model for ethylene dibromide : relevance of extrahepatic metabolism
article 2000    
Author: Hissink, A.M. · Wormhoudt, L.W. · Sherratt, P.J. · Hayes, J.D. · Commandeur, J.N.M. · Vermeulen, N.P.E. · Bladeren, P.J. van
Keywords: Ethylene dibromide · Extrapolation · Glutathione S-transferase · Interindividual variation · PBPK · Risk assessment · 1,2 dibromoethane · cytochrome P450 · glutathione · glutathione transferase · animal experiment · animal model · article · biotransformation · controlled study · male · nonhuman · pharmacokinetics · prediction · rat · risk assessment · toxicity testing · xenobiotic metabolism · Administration, Oral · Animals · Area Under Curve · Biotransformation · Chromatography, Gas · Cytochrome P-450 Enzyme System · Ethylene Dibromide · Glutathione Transferase · Humans · Injections, Intravenous · Liver · Male · Models, Biological · Rats · Rats, Wistar · Risk Assessment
[Abstract]

9 Polymorphism in the glutathione conjugation activity of human erythrocytes towards ethylene dibromide and 1,2-epoxy-3-(p-nitrophenoxy)-propane
article 1995    
Author: Ploemen, J.H.T.M. · Wormhoudt, L.W. · Ommen, B. van · Commandeur, J.N.M. · Vermeulen, N.P.E. · Bladeren, P.J. van
Keywords: Biology · Class theta · Chromatography, High Pressure Liquid · Cytosol · Dinitrochlorobenzene · Epoxy Compounds · Erythrocytes · Ethylene Dibromide · Glutathione · Glutathione Transferase · Human · Isoenzymes · Kinetics · Nitrophenols · Polymorphism (Genetics) · Support, Non-U.S. Gov't · Animalia
[Abstract]

10 Rat liver microsomal cytochrome P450-dependent oxidation of 3,5-disubstituted analogues of paracetamol
article 1996    
Author: Bessems, J.G.M. · Koppele, J.M. te · Dijk, P.A. van · Stee, L.L.P. van · Commandeur, J.N.M. · Vermeulen, N.P.E.
Keywords: Toxicology · beta naphthoflavone · cytochrome p450 · glutathione · paracetamol · paracetamol derivative · phenobarbital · animal tissue · article · controlled study · drug oxidation · liver microsome · male · nonhuman · rat · Acetaminophen · Animals · Benzoquinones · beta-Naphthoflavone · Cytochrome P-450 Enzyme System · Gas Chromatography-Mass Spectrometry · Glutathione · Imines · Kinetics · Male · Microsomes, Liver · Oxidation-Reduction · Rats · Rats, Wistar · Spectrophotometry, Ultraviolet · Animalia · Armoracia rusticana
[Abstract]

11 Enzyme kinetics and substrate selectivities of rat glutathione S-transferase isoenzymes towards a series of new 2-substituted 1-chloro-4-nitrobenzenes
article 1996    
Author: Aar, E.M. van der · Buikema, D. · Commandeur, J.N.M. · Koppele, J.M. te · Ommen, B. van · Bladeren, P.J. van · Vermeulen, N.P.E.
Keywords: Nutrition · glutathione transferase · isoenzyme · nitrobenzene derivative · animal tissue · article · controlled study · enzyme kinetics · enzyme specificity · glutathione metabolism · nonhuman · rat · Animals · Chromatography, Affinity · Dinitrochlorobenzene · Glutathione Transferase · Isoenzymes · Kidney · Kinetics · Liver · Rats · Spectrophotometry, Ultraviolet · Substrate Specificity · Animalia · Felis catus
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 11 of 11 found. | Sort by date