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1 Basil extract inhibits the sulfotransferase mediated formation of DNA adducts of the procarcinogen 1′-hydroxyestragole by rat and human liver S9 homogenates and in HepG2 human hepatoma cells
article 2008    
Author: Jeurissen, S.M.F. · Punt, A. · Delatour, T. · Rietjens, I.M.C.M.
Keywords: Alkenylbenzenes · DNA adducts · Estragole · Ocimum basilicum · Sulfotransferases · 1' hydroxyestragole · Animals · Anisoles · Biotransformation · Carcinoma, Hepatocellular · Cell Line, Tumor · Cell Survival · Chromatography, High Pressure Liquid · Deoxyguanosine · DNA Adducts · DNA Repair · Enzyme Inhibitors · Humans · Liver · Liver Neoplasms · Ocimum basilicum · Plant Extracts · Rats · Risk Assessment · Spectrometry, Mass, Electrospray Ionization · Subcellular Fractions · Sulfotransferases · Tetrazolium Salts · Thiazoles · Ocimum · Ocimum basilicum · Rattus
[Abstract]

2 A physiologically based biokinetic (PBBK) model for estragole bioactivation and detoxification in rat
article 2008    
Author: Punt, A. · Freidig, A.P. · Delatour, T. · Scholz, G. · Boersma, M.G. · Schilter, B. · Bladeren, P.J. van · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · Bioactivation · Detoxification · Estragole · In vitro · PBPK · Rat · 1' hydroxyestragole glucuronide · 1' sulfooxyestragole · Benzene derivative · Chavicol · Estragole · Glucuronide · Phenol derivative · Unclassified drug · Animal tissue · Arterial blood · Body fat · Controlled study · Detoxification · In vitro study · Kinetics · Liver · Nonhuman · Partition coefficient · Rat · Tissue perfusion · Venous blood · Allyl Compounds · Animals · Anisoles · Carcinogens · Dose-Response Relationship, Drug · Female · Glucuronides · Kidney · Lung · Male · Metabolic Detoxication, Drug · Models, Biological · Phenols · Rats · Rats, Sprague-Dawley · Rats, Wistar · Sulfones · Tissue Distribution · Rattus · Food and Nutrition · Healthy Living
[Abstract]

Search results also available in MS Excel format.

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