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1 Lack of clastogenic effects in cultured human lymphocytes treated with hydroquinone
article 2003    
Author: Roza, L. · Vogel, N. de · Delft, J.H.M. van
Keywords: Biology Health · Physiological Sciences · Antimutagen · Clastogenicity · Human lymphocytes · Hydroquinone · Mutagenicity · hydrogen peroxide · hydroquinone · hydroquinone derivative · mutagenic agent · oxidizing agent · article · concentration response · controlled study · cytotoxicity · genotoxicity · human · human cell · lymphocyte culture · male · metabolic activation · mutagenicity · normal human · structural chromosome aberration · animal · biotransformation · cell culture · chromatid · chromosome aberration · drug effect · in vitro study · liver · lymphocyte · metabolism · mutagen testing · rat · Wistar rat · Animalia · Animals · Biotransformation · Cells, Cultured · Chromatids · Chromosome Aberrations · Humans · Hydrogen Peroxide · Hydroquinones · Liver · Lymphocytes · Male · Mutagenicity Tests · Mutagens · Oxidants · Rats · Rats, Wistar
[Abstract]

2 Germ cell mutagenesis in lambdalacZ transgenic mice treated with ethylnitrosourea : comparison with specific-locus test
article 1995    
Author: Delft, J.H.M. van · Baan, R.A.
Keywords: Biology · Animal · Comparative Study · DNA · Dose-Response Relationship, Drug · Ethylnitrosourea · Guanidine · Guanidines · Lac Operon · Male · Mice · Mice, Transgenic · Mutagenesis · Mutagenicity Tests · Spermatogenesis · Spermatozoa · Support, Non-U.S. Gov't · Time Factors
[Abstract]

3 Biological effect markers for exposure to carcinogenic compound and their relevance for risk assessment
article 1998    
Author: Delft, J.H.M. van · Baan, R.A. · Roza, L.
Keywords: Nutrition · Biomarker · Cancer mortality · Cytogenetic damage · DNA adduct · Aromatic compound · Biological marker · Cytostatic agent · Ethylene oxide derivative · Hydrocarbon · Pesticide · Animal tissue · Cancer mortality · Cancer risk · Carcinogenicity · Cell heterogeneity · Chromosome aberration · Cytogenetics · Dna adduct · Human · Human tissue · Micronucleus · Nonhuman · Pathophysiology · Population exposure · Review · Risk assessment · Animals · Carcinogens · Chromosome Aberrations · DNA Adducts · Epidemiologic Methods · Genetic Markers · Humans · Mutation · Neoplasms · Neoplasms, Experimental · Occupational Exposure · Risk Assessment · Tumor Markers, Biological
[Abstract]

4 Genotoxicity evaluation of wood-derived and vegetable oil-derived stanol esters
article 1999    
Author: Turnbull, D. · Frankos, V.H. · Delft, J.H.M. van · Vogel, N. de

5 The micronucleus test with N-methyl-N'-nitro-N-nitrosoguanidine showing significant effects in bone marrow and peripheral blood of rats
article 1996    
Author: Verhagen, H. · Bruijntjes, J.P. · Vogel, N. de · Delft, J.H.M. van
Keywords: Nutrition

6 Genotoxicity evaluation of wood-derived and vegetable oil-derived stanol esters
article 1999    
Author: Turnbull, D. · Frankos, V.H. · Delft, J.H.M. van · Vogel, N. de
Keywords: Nutrition · Fatty acid ester · Vegetable oil · Chemical structure · Chromosome aberration · Food safety · Gene mutation · Genotoxicity · Mammal cell · Priority journal · Salmonella typhimurium · Wood · Animals · Carcinogenicity Tests · CHO Cells · Chromosome Aberrations · Cricetinae · DNA Mutational Analysis · Evaluation Studies · Mice · Mutagens · Phytosterols · Plant Oils · Salmonella typhimurium · Tumor Cells, Cultured · Wood · Bacteria (microorganisms) · Mammalia · Salmonella typhimurium · Typhimurium
[Abstract]

7 DNA adducts, mutant frequencies and mutation spectra in λlacZ transgenic mice treated with N-nitrosodimethylamine
article 1998    
Author: Souliotis, V.L. · Delft, J.H.M. van · Steenwinkel, M.-J.S.T. · Baan, R.A. · Kyrtopoulos, S.A.
Keywords: Nutrition · 6 o alkylguanine dna alkyltransferase · 6 o methylguanine · 7 methylguanine · Beta galactosidase · Dimethylnitrosamine · Dna · Animal experiment · Animal tissue · Carcinogenesis · Controlled study · Dna adduct · Liver · Male · Mouse · Mutation rate · Nonhuman · Priority journal · Spleen · Transgenic mouse · Animals · Carcinogens · Dimethylnitrosamine · DNA Adducts · Lac Operon · Male · Mice · Mice, Transgenic · Mutagens · Mutation · Sequence Deletion
[Abstract]

8 Comparison of the X-gal- and P-gal-based systems for screening of mutant λlacZ phages originating from the transgenic mouse strain 40.6
article 1996    
Author: Mientjes, E.J. · Steenwinkel, M.J.S.T. · Delft, J.H.M. van · Lohman, P.H.M. · Baan, R.A.
Keywords: Nutrition · λgt10lacZ phage · Muta Mouse · P-gal · Positive selection · Transgenic mouse, strain 40.6 · X-gal · benzo[a]pyrene · ethylnitrosourea · animal experiment · article · bacteriophage · brain · controlled study · female · genotoxicity · liver · mouse · mutagen testing · mutant · mutation rate · nonhuman · priority journal · screening test · transgenic mouse · Animals · Bacteriophage lambda · Benzo(a)pyrene · Brain · Ethylnitrosourea · Galactosides · Indoles · Liver · Mice · Mice, Transgenic · Mutagens · Mutation
[Abstract]

9 Methyl bromide causes DNA methylation in rats and mice but fails to induce somatic mutations in lambda lacZ trangenic mice
article 1999    
Author: Pletsa, V. · Steenwinkel, M.-J.S.T. · Delft, J.H.M. van · Baan, R.A. · Kyrtopoulos, S.A.
Keywords: Chemistry

10 Induction of somatic mutations but not methylated DNA adducts in λlacZ transgenic mice by dichlorvos
article 1999    
Author: Pletsa, V. · Steenwinkel, M.-J.S.T. · Delft, J.H.M. van · Baan, R.A. · Kyrtopoulos, S.A.
Keywords: Nutrition · Dimethylsulphate · Methylating agents · N7-Methylguanine · O6-Methylguanine · Organosphosphate insecticides · 6 o methylguanine · 7 methylguanine · Dichlorvos · Dimethyl sulfate · Animal cell · Bone marrow cell · Controlled study · DNA adduct · DNA methylation · Genotoxicity · Liver cell · Mouse · Mutation rate · Nonhuman · Priority journal · Somatic mutation · Transgenic mouse · Animals · Dichlorvos · DNA Methylation · Guanine · Insecticides · Lac Operon · Mice · Mice, Transgenic · Mutation · Mus musculus
[Abstract]

11 Methyl bromide causes DNA methylation in rats and mice but fails to induce somatic mutations in λlacZ transgenic mice
article 1998    
Author: Pletsa, V. · Steenwinkel, M.-J.S.T. · Delft, J.H.M. van · Baan, R.A. · Kyrtopoulos, S.A.
Keywords: Nutrition · Methylating agents · N7-methylguanine · O6-Alkylguanine-DNA alkyltransferase · O6-Methylguanine · Pesticides · Somatic mutation · 6 o alkylguanine DNA alkyltransferase · 6 o methylguanine · 7 methylguanine · Methyl bromide · Pesticide · Animal cell · Animal experiment · Bone marrow · Controlled study · DNA adduct · DNA methylation · Female · Gene mutation · Mouse · Nonhuman · Priority journal · Somatic mutation · Stomach · Tissue distribution · Transgenic mouse · Animals · DNA Adducts · DNA Methylation · Dose-Response Relationship, Drug · Guanine · Hydrocarbons, Brominated · Lac Operon · Male · Mice · Mice, Transgenic · Mutagenesis · Mutagens · O(6)-Methylguanine-DNA Methyltransferase · Rats · Rats, Sprague-Dawley · Mus musculus
[Abstract]

12 Determination of N7-(2-hydroxyethyl)guanine by HPLC with electrochemical detection
article 1991    
Author: Delft, J.H.M. van · Weert, E.J.M. van · Winden, M.J.M. van · Baan, R.A.
Keywords: Biology

13 Binary PAH mixtures cause additive or antagonistic effects on gene expression but synergistic effects on DNA adduct formation
article 2007    
Author: Staal, Y.C.M. · Hebels, D.G.A.J. · Herwijnen, M.H.M. van · Gottschalk, R.W.H. · Schooten, F.J. van · Delft, J.H.M. van
Keywords: Toxicology and Applied Pharmacology · benzo[a]pyrene · benzo[b]fluoranthene · dibenz[a,h]anthracene · dibenzo[a,l]pyrene · fluoranthene · phenanthrene derivative · polycyclic aromatic hydrocarbon · apoptosis · article · carcinogenesis · carcinogenicity · cell cycle · cell strain HepG2 · controlled study · DNA adduct · exposure · gene expression · hepatoma cell · human · human cell · nucleotide sequence · priority journal · unindexed sequence · Air Pollutants · Apoptosis · Cell Cycle · Cell Line, Tumor · DNA Adducts · Drug Antagonism · Drug Synergism · Gene Expression Profiling · Gene Expression Regulation, Neoplastic · Humans · Polycyclic Hydrocarbons, Aromatic
[Abstract]

14 A sandwich-cultured rat hepatocyte system with increased metabolic competence evaluated by gene expression profiling
article 2007    
Author: Kienhuis, A.S. · Wortelboer, H.M. · Maas, W.J. · Herwijnen, M. van · Kleinjans, J.C.S. · Delft, J.H.M. van · Stierum, R.H.
Keywords: Biology · Biomedical Research · Gene expression profiling · In vitro models · Metabolic competence · Primary rat hepatocytes · Sandwich-culture · beta naphthoflavone · cytochrome P450 · dexamethasone · phenobarbital · animal cell · article · cell culture · culture medium · enzyme activity · gene expression · gene expression profiling · in vitro study · in vivo study · liver · liver cell · male · metabolic capacity · model · nonhuman · nucleotide sequence · rat · Actins · Animals · Biotransformation · Cytochrome P-450 Enzyme System · Cytological Techniques · Data Interpretation, Statistical · Gene Expression Profiling · Hepatocytes · Hydroxylation · Male · Nucleic Acid Hybridization · Oligonucleotide Array Sequence Analysis · Rats · Rats, Wistar · Reverse Transcriptase Polymerase Chain Reaction · RNA · Testosterone · Rattus
[Abstract]

15 Time series analysis of benzo[a]pyrene-induced transcriptome changes suggests that a network of transcription factors regulates the effects on functional gene sets
article 2010    
Author: Delft, J.H.M. van · Mathijs, K. · Staal, Y.C.M. · Herwijnen, M.H.M. van · Brauers, K.J.J. · Boorsma, A. · Kleinjans, J.C.S.
Keywords: Nutrition · Biomedical Research · Carcinogen · Network · Time series · Transcription factor · Transcriptome · benzo[a]pyrene · immunoglobulin enhancer binding protein · Myc protein · serum response factor · transcription factor · transcription factor AP 1 · transcription factor E2F1 · transcriptome · amino acid metabolism · apoptosis · article · carcinogenesis · cell cycle G1 phase · cell cycle S phase · controlled study · correlation analysis · DNA adduct · DNA repair · down regulation · functional genomics · gene expression · gene regulatory network · hepatoma cell · human · human cell · lipid metabolism · named inventories, questionnaires and rating scales · proto oncogene · Short Time series Expression Miner · signal transduction · time series analysis · transcription regulation · tumor suppressor gene · upregulation
[Abstract]

16 Comparison of coumarin-induced toxicity between sandwich-cultured primary rat hepatocytes and rats in vivo: A toxicogenomics approach
article 2006    
Author: Kienhuis, A.S. · Wortelboer, H.M. · Hoflack, J.C. · Moonen, E.J. · Kleinjans, J.C.S. · Ommen, B. van · Delft, J.H.M. van · Stierum, R.H.
Keywords: Biology · Biomedical Research · beta naphthoflavone · coumarin · cytochrome P450 · dexamethasone · drug metabolite · enzyme inducing agent · phenobarbital · animal cell · animal experiment · animal model · animal tissue · article · controlled study · culture medium · cytotoxicity · drug activation · drug metabolism · enzyme activity · experimental rat · gene expression · histopathology · in vitro study · in vivo study · liver cell · liver toxicity · male · nonhuman · nucleotide sequence · prediction · principal component analysis · priority journal · rat · signal transduction · toxicogenetics · Alanine Transaminase · Animals · Aspartate Aminotransferases · Cell Culture Techniques · Cells, Cultured · Cholesterol · Coumarins · gamma-Glutamyltransferase · Gene Expression Profiling · Hepatocytes · Liver · Male · Oligonucleotide Array Sequence Analysis · Rats · Rats, Wistar · Toxicogenetics
[Abstract]

17 Methyl DNA adducts, DNA repair, and hypoxanthine-guanine phosphoribosyl transferase mutations in peripheral white blood cells from patients with malignant melanoma treated with dacarbazine and hydroxyurea
article 1996    
Author: Philip, P.A. · Souliotis, V.L. · Harris, A.L. · Salisbury, A. · Tates, A.D. · Mitchell, K. · Delft, J.H.M. van · Ganesan, T.S. · Kyrtopoulos, S.A.
Keywords: Biology · dacarbazine · hydroxyurea · hypoxanthine phosphoribosyltransferase · adult · aged · article · clinical article · dna adduct · dna repair · female · gene mutation · human · intravenous drug administration · leukocyte · male · melanoma · priority journal · Antineoplastic Combined Chemotherapy Protocols · Dacarbazine · DNA Adducts · DNA Repair · Female · Guanine · Humans · Hydroxyurea · Hypoxanthine Phosphoribosyltransferase · Leukocytes · Male · Melanoma · Middle Aged · Mutation · O(6)-Methylguanine-DNA Methyltransferase
[Abstract]

18 Gene-mutation assays in lambda-lacZ transgenic mice : comparison of lacZ with endogenous genes in splenocytes and small intestinal epithelium
article 1998    
Author: Delft, J.H.M. van · Bergmans, A. · Dam, F.J. van · Tates, A.D. · Howard, L. · Winton, D.J. · Baan, R.A.
Keywords: Biology · λlacZ · Dlb-1 · hprt · Mutagenesis · Transgenic mouse · ethylnitrosourea · hypoxanthine phosphoribosyltransferase · mesylic acid ethyl ester · methylnitrosourea · mutagenic agent · animal cell · animal experiment · animal tissue · article · controlled study · gene · gene mutation · intestine epithelium · mouse · mutagenesis · mutagenicity · nonhuman · priority journal · small intestine mucosa · spleen cell · transgenic mouse · Alkylating Agents · Animals · Ethyl Methanesulfonate · Ethylnitrosourea · Genetic Markers · Hypoxanthine Phosphoribosyltransferase · Intestinal Mucosa · Intestine, Small · Lac Operon · Methylnitrosourea · Mice · Mice, Inbred C57BL · Mice, Transgenic · Mutagenicity Tests · Mutagens · Mutation · Spleen · Animalia · Mus musculus
[Abstract]

19 Interlaboratory and interplatform comparison of microarray gene expression analysis of HepG2 cells exposed to benzo(a)pyrene
article 2009    
Author: Hockley, S.L. · Mathijs, K. · Staal, Y.C.M. · Brewer, D. · Giddings, I. · Delft, J.H.M. van · Phillips, D.H.
Keywords: Biology · Toxicology and Applied Pharmacology · benzo[a]pyrene · RNA · article · cell strain HepG2 · correlation analysis · data analysis · DNA microarray · false negative result · gene expression profiling · human · human cell · intermethod comparison · laboratory · microarray analysis · nucleotide sequence · principal component analysis · priority journal · quantitative assay · real time polymerase chain reaction · transcriptomics · validation process
[Abstract]

20 DNA adducts, mutant frequencies, and mutation spectra in various organs of λlacZ mice exposed to ethylating agents
article 1998    
Author: Mientjes, E.J. · Luiten-Schuite, A. · Wolf, E. van der · Borsboom, Y. · Bergmans, A. · Berends, F. · Lohman, P.H.M. · Baan, R.A. · Delft, J.H.M. van
Keywords: Nutrition · λlacZ transgenic mice · Ethyl DNA adducts · Muta(TM)Mouse · Mutagenesis · Mutation spectra · Alkylating agent · Diethylnitrosamine · Ethylnitrosourea · Guanine derivative · Mesylic acid ethyl ester · Animal experiment · Animal tissue · Bone marrow · Brain · Controlled study · Dna adduct · Female · Liver · Mouse · Mutagenesis · Mutation · Mutation rate · Nonhuman · Sequence analysis · Transgenic mouse · Animals · Bone Marrow · Brain · Diethylnitrosamine · DNA Adducts · Ethyl Methanesulfonate · Ethylnitrosourea · Female · Guanine · Lac Operon · Liver · Mice · Mice, Transgenic · Mutagens
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 36 found. Next | Sort by date