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1 Apolipoprotein AV: Low concentration, high impact
article 2005    
Author: Rensen, P.C.N. · Dijk, K.W. van · Havekes, L.M.
Keywords: Biomedical Research · Apolipoprotein A5 · High density lipoprotein · Lipoprotein lipase · Low density lipoprotein receptor · Triacylglycerol · Very low density lipoprotein · APOA5 protein, human · Editorial · Enzyme linked immunosorbent assay · Homeostasis · Ischemic heart disease · Lipid metabolism · Nonhuman · Protein assembly · Triacylglycerol blood level · Animal · Blood · Metabolism · Note · Physiology · Animals · Apolipoproteins · Apolipoproteins A · Homeostasis · Humans · Hypertriglyceridemia · Triglycerides
[Abstract]

2 Generation of a recombinant apolipoprotein E variant with improved biological functions: Hydrophobic residues (LEU-261, TRP-264, PHE-265, LEU-268, VAL-269) of apoE can account for the apoE-induced hypertriglyceridemia
article 2005    
Author: Kypreos, K.E. · Dijk, K.W. van · Havekes, L.M. · Zannis, V.I.
Keywords: Biology · Biomedical Research · Amino acids · Biochemistry · Cholesterol · Genes · Molecular biology · Mutagenesis · Alanines · Apolipoprotein E (apoE) · High density lipoprotein (HDL) · Ultracentrifugation analysis · Proteins · High density lipoprotein · Leucine · Lipoprotein lipase · Phenylalanine · Recombinant apolipoprotein E · Recombinant protein · Triacylglycerol · Tryptophan · Unclassified drug · Valine · Very low density lipoprotein · Adenovirus · Amino acid substitution · Animal experiment · Carboxy terminal sequence · Controlled study · Density gradient centrifugation · Electron microscopy · Gene transfer · Human cell · Hydrophobicity · Hyperlipidemia · Hypertriglyceridemia · Mouse · Mutation · Nonhuman · Protein expression · Protein function · Animals · Apolipoproteins E · Cholesterol · Female · Humans · Hypertriglyceridemia · Lipoproteins, HDL · Lipoproteins, VLDL · Liver · Mice · Mice, Knockout · Mutagenesis, Site-Directed · Mutation, Missense · Peptide Fragments · Recombinant Proteins · Transgenes · Triglycerides
[PDF] [Abstract]

3 Macrophage scavenger receptor class A: A multifunctional receptor in atherosclerosis
article 2000    
Author: Winther, M.P.J. de · Dijk, K.W. van · Havekes, L.M. · Hofker, M.H.
Keywords: Animals · Arteriosclerosis · Cell Adhesion · Cell Communication · Foam Cells · Humans · Immunity · Receptors, Immunologic · Receptors, Scavenger · Scavenger Receptors, Class A
[Abstract]

4 Clearance of coagulation factor VIII in very low-density lipoprotein receptor knockout mice
article 2004    
Author: Bovenschen, N. · Dijk, K.W. van · Havekes, L.M. · Mertens, K. · Vlijmen, B.J.M. van
Keywords: Biology · Biomedical Research · Clearance · Factor VIII · Knockout mice · Low-density lipoprotein receptor-related protein · Very low-density lipoprotein receptor · blood clotting factor 8 · cholesterol · triacylglycerol · very low density lipoprotein receptor · animal experiment · article · catabolism · cholesterol blood level · controlled study · knockout mouse · male · mouse · nonhuman · plasma clearance · priority journal · triacylglycerol blood level · Animals · Factor VIII · Integrases · LDL-Receptor Related Proteins · Mice · Mice, Knockout · Mice, Transgenic · Receptors, LDL
[Abstract]

5 ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpression
article 2005    
Author: Gerritsen, G. · Rensen, P.C.N. · Kypreos, K.E. · Zannis, V.I. · Havekes, L.M. · Dijk, K.W. van
Keywords: Biology · Biomedical Research · Adenovirus-mediated gene transfer · Lipoprotein lipase-mediated triglyceride hydrolysis · Mice · Very low density lipoprotein · Cholesterol · Fatty acid · Intermediate density lipoprotein · Lipoprotein · Triacylglycerol · Lipid · Lipoprotein lipase · Animal experiment · Animal tissue · Cholesterol blood level · Controlled study · Dose response · Emulsion · Female · Gene dosage · Gene overexpression · Hydrolysis · Hyperlipidemia · In vitro study · In vivo study · Injection · Lipoprotein deficiency · Mouse · Nonhuman · Protein blood level · White adipose tissue · Animal · Biosynthesis · Blood · Genetic transfection · Genetics · Metabolism · Mouse mutant · Animals · Apolipoprotein C-III · Apolipoprotein E4 · Apolipoproteins C · Apolipoproteins E · Humans · Hyperlipidemias · Lipids · Lipoprotein Lipase · Lipoproteins · Lipoproteins, VLDL · Mice · Mice, Knockout · Transfection · Triglycerides
[PDF] [Abstract]

6 Domains of apolipoprotein E contributing to triglyceride and cholesterol homeostasis in vivo. Carboxyl-terminal region 203-299 promotes hepatic very low density lipoprotein-triglyceride secretion
article 2001    
Author: Kypreos, K.E. · Dijk, K.W. van · Zee, A. van der · Havekes, L.M. · Zannis, V.I.
Keywords: Biology · Adenoviridae · Animalia · Adenoviridae · Animals · Apolipoprotein E4 · Apolipoproteins E · Base Sequence · Cholesterol · Chromatography, Liquid · DNA Primers · Female · Homeostasis · Humans · Liver · Mice · Mice, Knockout · RNA, Messenger · Triglycerides · Tumor Cells, Cultured
[PDF] [Abstract]

7 Stimulation of the in Vivo Production of Very Low Density Lipoproteins by Apolipoprotein E Is Independent of the Presence of the Low Density Lipoprotein Receptor
article 2001    
Author: Teusink, B. · Mensenkamp, A.R. · Boom, H. van der · Kuipers, F. · Dijk, K.W. van · Havekes, L.M.
Keywords: Animalia · Gillia · Animals · Apolipoproteins E · Lipoproteins, VLDL · Male · Mice · Mice, Inbred C57BL · Mice, Knockout · Receptors, LDL
[PDF] [Abstract]

8 Use of transgenic mice in lipoprotein metabolism and atherosclerosis research
article 1997    
Author: Havekes, L.M. · Vlijmen, B.J.M. van · Jong, M.C. · Dijk, K.W. van · Hofker, M.H.
Keywords: Biology · Age Factors · Animals · Apolipoprotein E3 · Apolipoproteins C · Apolipoproteins E · Arteriosclerosis · Cholesterol · Female · Humans · Lipids · Lipoproteins · Lipoproteins, VLDL · Male · Mice · Mice, Transgenic · Sex Factors · Animalia · Mus musculus
[Abstract]

9 Effect of plasma triglyceride metabolism on lipid storage in adipose tissue: Studies using genetically engineered mouse models
article 2009    
Author: Voshol, P.J. · Rensen, P.C.N. · Dijk, K.W. van · Romijn, J.A. · Havekes, L.M.
Keywords: Biology · Biomedical Research · Animal model · Fatty acid · Fatty acid transporter · Lipid metabolism · Lipoprotein lipase · Metabolic syndrome · Obesity · Animalia
[Abstract]

10 Macrophage-specific inhibition of NF-κB activation reduces foam-cell formation
article 2007    
Author: Ferreira, V. · Dijk, K.W. van · Groen, A.K. · Vos, R.M. · Kaa, J. van der · Gijbels, M.J.J. · Havekes, L.M. · Pannekoek, H.
Keywords: Biology · Biomedical Research · ABCA1 mediated cholesterol efflux · Foam cell formation · Macrophage specific inhibition of NF-κB, IκBα · ox-LDL-PPARγ-CD36 "feed-forward cycle" · I kappa B kinase alpha · immunoglobulin enhancer binding protein · article · cell differentiation · cell line · cell specificity · controlled study · cytoplasm · foam cell · gene expression · human · human cell · lipid oxidation · lipid transport · monocyte · mouse · nonhuman · peritoneum cell · priority journal · protein degradation · protein expression · transgenic mouse · Animals · Antigens, CD36 · ATP-Binding Cassette Transporters · Cell Line · DNA-Binding Proteins · Foam Cells · Humans · I-kappa B Proteins · Lipoproteins, LDL · Macrophages · Mice · Mice, Inbred C57BL · NF-kappa B · PPAR gamma · Receptors, Cytoplasmic and Nuclear · Scavenger Receptors, Class A
[Abstract]

11 Genomic cloning of the mouse LDL receptor related protein/_2-macroglobulin receptor gene
article 1994    
Author: Zee, A. van der · Stas, L. · Hilleker, C. · Leuven, F. van · Dijk, K.W. van · Havekes, L · Frants, R.A. · Hofker, M.H.
Keywords: Biology
[Abstract]

12 Effect of macrophage-derived mouse ApoE, human ApoE3-Leiden, and human ApoE2 (Arg158→Cys) on cholesterol levels and atherosclerosis in ApoE- deficient mice
article 2000    
Author: Eck, M. van · Herijgers, N. · Dijk, K.W. van · Havekes, L.M. · Hofker, M.H. · Groot, P.H.E. · Berkel, T.J.C. van
Keywords: Atherosclerosis · Hyperlipidemia · Low density lipoprotein · Animal model · Animal tissue · Cholesterol blood level · Cholesterol transport · Mouse · Nonhuman · Transgenic mouse · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Bone Marrow Transplantation · Cholesterol · Humans · Liver · Macrophages, Peritoneal · Mice · Mice, Knockout · Mice, Transgenic
[Abstract]

13 Hyperlipidemia in APOE2 transgenic mice is ameliorated by a truncated apoE variant lacking the C-terminal domain
article 2003    
Author: Gerritsen, G. · Kypreos, K.E. · Zee, A. van der · Teusink, B. · Zannis, V.I. · Havekes, L.M. · Dijk, K.W. van
Keywords: Biology · Adenoviridae · Animals · Apolipoprotein E2 · Apolipoprotein E4 · Apolipoproteins E · Cholesterol · Humans · Hyperlipidemias · Lipids · Lipoproteins · Lipoproteins, VLDL · Liver · Mice · Mice, Transgenic · Protein Isoforms · Protein Structure, Tertiary · Triglycerides
[PDF] [Abstract]

14 Protection from obesity in mice lacking the VLDL receptor
article 2001    
Author: Goudriaan, J.R. · Tacken, P.J. · Dahlmans, V.E.H. · Gijbels, M.J.J. · Dijk, K.W. van · Havekes, L.M. · Jong, M.C.
Keywords: Adipose Tissue · Animals · Diet, Atherogenic · Fatty Acids · Glucose Tolerance Test · Insulin Resistance · Mice · Mice, Knockout · Mice, Obese · Mice, Transgenic · Obesity · Receptors, LDL · Triglycerides · Weight Gain
[Abstract]

15 Mice expressing only the mutant APOE3Leiden gene show impaired VLDL secretion
article 2001    
Author: Mensenkamp, A.R. · Teusink, B. · Baller, J.F.W. · Wolters, H. · Havinga, R. · Dijk, K.W. van · Havekes, L.M. · Kuipers, F.
Keywords: Animals · Apolipoprotein E3 · Apolipoproteins B · Apolipoproteins E · Fatty Liver · Lipid Metabolism · Lipoproteins, VLDL · Liver · Mice · Mice, Transgenic · Protein Isoforms · RNA, Messenger · Triglycerides
[Abstract]

16 Adenovirus mediated overexpression of human phospholipid transfer protein alters plasma HDL levels in mice
article 1998    
Author: Ehnholm, S. · Dijk, K.W. van · Hof, B. van · Zee, A.D. van · Olkkonen, V.M. · Jauhiainen, M. · Hofker, M. · Havekes, L. · Ehnholm, C.
Keywords: Biology · Apolipoprotein A-I · HDL conversion · HDL metabolism · Lipid metabolism · Phospholipid transfer protein · Recombinant adenovirus · Adenoviridae · Animals · Apolipoprotein A-I · Carrier Proteins · Cholesterol · Cholesterol Esters · Female · Genetic Vectors · Humans · Lipoproteins · Lipoproteins, HDL · Liver · Membrane Proteins · Mice · Mice, Inbred C57BL · Mice, Transgenic · Phospholipid Transfer Proteins · Phospholipids · Recombinant Proteins · Triglycerides
[PDF] [Abstract]

17 Binding of β-VLDL to heparan sulfate proteoglycans requires lipoprotein lipase, whereas apoE only modulates binding affinity
article 1999    
Author: Beer, F. de · Hendriks, W.L. · Vark, L.C. van · Kamerling, S.W.A. · Dijk, K.W. van · Hofker, M.H. · Smelt, A.H.M. · Havekes, L.M.
Keywords: Biology · β-VLDL · apoE · Heparan sulfate proteoglycans · Lipoprotein lipase · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Binding, Competitive · Cell Line · Cholesterol, VLDL · Heparan Sulfate Proteoglycans · Iodine Radioisotopes · Lipoprotein Lipase · Macrophages · Mice · Mice, Knockout
[Abstract]

18 Inhibition of neointima formation by local delivery of estrogen receptor alpha and beta specific agonists
article 2007    
Author: Krom, Y.D. · Pires, N.M.M. · Jukema, J.W. · Vries, M.R. de · Frants, R.R. · Havekes, L.M. · Dijk, K.W. van · Quax, P.H.A.
Keywords: Biology · Biomedical Research · Animal model · Estrogens · Hormones · Receptors · Restenosis · 2,3 bis(4 hydroxyphenyl)propionitrile · 4,4',4'' (4 propyl [1h] pyrazole 1,3,5 triyl)tris phenol · antiestrogen · estradiol · estrogen receptor alpha · estrogen receptor beta · methylpiperidinopyrazole · phenol derivative · propionitrile · pyrazole derivative · agonist · animal cell · animal model · article · controlled study · cuff · dose response · drug eluting stent · femoral artery · hormone inhibition · intima · male · mouse · nonhuman · priority journal · restenosis · sensitivity and specificity · Animals · Cell Proliferation · Drug Implants · Estradiol · Estrogen Receptor alpha · Estrogen Receptor beta · Femoral Artery · Immunohistochemistry · Male · Mice · Mice, Inbred C57BL · Models, Animal · Nitriles · Propionates · Pyrazoles · Reverse Transcriptase Polymerase Chain Reaction · Tunica Intima
[Abstract]

19 Metabolomics (liver and blood profiling) in a mouse model in response to fasting: A study of hepatic steatosis
article 2007    
Author: Ginneken, V. van · Verhey, E. · Poelmann, R. · Ramakers, R. · Dijk, K.W. van · Ham, L. · Voshol, P. · Havekes, L. · Eck, M. van · Greef, J. van der
Keywords: Analytical research · Biomedical research · Hepatic steatosis · Lipids · Liver · Metabolomics · Starvation · Triacylglycerols · cholesterol · cholesterol ester · low density lipoprotein cholesterol · phosphatidylcholine · phospholipid derivative · triacylglycerol · animal experiment · animal model · animal tissue · article · blood examination · controlled study · diet restriction · fatty liver · high performance thin layer chromatography · lipid blood level · lipid storage · liver homogenate · male · mass spectrometry · metabolomics · mouse · nonhuman · priority journal · reversed phase liquid chromatography · starvation · Animals · Blood · Cholesterol Esters · Chromatography, High Pressure Liquid · Disease Models, Animal · Fatty Liver · Food Deprivation · Lipoproteins, LDL · Liver · Male · Mice · Mice, Inbred C57BL · Phosphatidylcholines · Phospholipids · Triglycerides · Mammalia
[Abstract]

20 Improving the analysis of designed studies by combining statistical modelling with study design information
article 2009    
Author: Thissen, U. · Wopereis, S. · Berg, S.A.A. van den · Bobeldijk, I. · Kleemann, R. · Kooistra, T. · Dijk, K.W. van · Ommen, B. van · Smilde, A.K.
Keywords: Biology · Biomedical Research · Animals · Databases, Factual · Humans · Metabolomics · Models, Statistical
[PDF] [Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 55 found. Next | Sort by date