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1 In vivo suppression of vein graft disease by nonviral, electroporation-mediated, gene transfer of tissue inhibitor of metalloproteinase-1 linked to the amino terminal fragment of urokinase (TIMP-1.ATF), a cell-surface directed matrix metalloproteinase inhibitor
article 2010    
Author: Eefting, D. · Vries, M.R. de · Grimbergen, J.M. · Karper, J.C. · Bockel, J.H. van · Quax, P.H.A.
Keywords: Biology
[Abstract]

2 Sirolimus and paclitaxel provoke different vascular pathological responses after local delivery in a murine model for restenosis on underlying atherosclerotic arteries
article 2007    
Author: Pires, N.M.M. · Eefting, D. · Vries, M.R.de · Quax, P.H.A. · Jukema, J.W.
Keywords: Biology · Biomedical Research · collagen · Fas antigen · gelatinase B · messenger RNA · paclitaxel · protein Bax · protein bcl 2 · rapamycin · tissue inhibitor of metalloproteinase 1 · animal experiment · animal model · animal tissue · apoptosis · article · atherosclerosis · blood vessel reactivity · cell disruption · controlled study · dose response · drug eluting stent · drug megadose · femoral artery · histopathology · hypercholesterolemia · male · mouse · nonhuman · priority journal · protein expression · real time polymerase chain reaction · restenosis · upregulation · Actins · Animals · Apoptosis · Atherosclerosis · Cell Proliferation · Collagen · Drug Implants · Femoral Artery · Image Interpretation, Computer-Assisted · In Situ Nick-End Labeling · Male · Mice · Mice, Mutant Strains · Models, Animal · Muscle, Smooth, Vascular · Paclitaxel · Recurrence · Reverse Transcriptase Polymerase Chain Reaction · RNA, Messenger · Sirolimus · Stents · Tunica Intima
[Abstract]

3 Short-term dexamethasone treatment inhibits vein graft thickening in hypercholesterolemic ApoE3Leiden transgenic mice
article 2006    
Author: Schepers, A. · Pires, N.M.M. · Eefting, D. · Vries, M.R. de · Bokel, J.H. van · Quax, P.H.A.
Keywords: Biology · Biomedical Research · Dexamethasone · Animal experiment · Animal model · Animal tissue · Artery intima proliferation · Carotid artery · Controlled study · Hypercholesterolemia · Mouse · Nonhuman · Protein expression · Short course therapy · Transgenic mouse · Vein graft · Vein graft disease · Vein graft thickening · Animals · Apolipoprotein E3 · Apolipoproteins E · Atherosclerosis · Base Sequence · Dexamethasone · Disease Models, Animal · Drug Administration Schedule · Endothelium, Vascular · Graft Occlusion, Vascular · Graft Rejection · Graft Survival · Humans · Hypercholesterolemia · Male · Mice · Mice, Inbred C57BL · Mice, Transgenic · Molecular Sequence Data · Reverse Transcriptase Polymerase Chain Reaction · Risk Assessment · RNA, Messenger · Saphenous Vein · Sensitivity and Specificity · Treatment Outcome · Vascular Surgical Procedures
[Abstract]

4 Local lentiviral short hairpin RNA silencing of CCR2 inhibits vein graft thickening in hypercholesterolemic apolipoprotein E3-Leiden mice
article 2009    
Author: Eefting, D. · Bot, I. · Vries, M.R. de · Schepers, A. · Bockel, J.H. van · Berkel, T.J.C. van · Biessen, E.A.L. · Quax, P.H.A.
Keywords: Biology · Biomedical Research · apolipoprotein E3 · chemokine receptor CCR2 · lentiviral short hairpin RNA · lentivirus vector · messenger RNA · monocyte chemotactic protein 1 · unclassified drug · animal cell · animal model · article · atherosclerosis · carotid artery · cell migration · cell proliferation · clinical feature · controlled study · disease course · drug delivery system · drug efficacy · drug targeting · gene silencing · gene therapy · hypercholesterolemia · in vitro study · in vivo study · infection · Lentivirinae · male · morphometrics · mouse · nonhuman · priority journal · protein expression · receptor upregulation · smooth muscle fiber · treatment outcome · vein graft · vein graft disease · vein surgery · viral gene delivery system · Animals · Apolipoprotein E3 · Atherosclerosis · Chemokine CCL2 · Disease Models, Animal · Graft Occlusion, Vascular · Hypercholesterolemia · Lentivirus · Male · Mice · Receptors, CCR2 · RNA Interference · Veins
[Abstract]

5 A novel urokinase receptor-targeted inhibitor for plasmin and matrix metalloproteinases suppresses vein graft disease
article 2010    
Author: Eefting, D. · Seghers, L. · Grimbergen, J.M. · Vries, M.R. de · Boer, H.C. de · Lardenoye, J.W.H.P. · Jukema, J.W. · Bockel, J.H. van · Quax, P.H.A.
Keywords: Health · Biomedical Research · Gene therapy · Matrix metalloproteinases · Plasmin(ogen) · Vascular surgery · Vein graft disease · apolipoprotein E3 · aprotinin · hybrid protein · matrix metalloproteinase · matrix metalloproteinase inhibitor · plasmin · plasmin inhibitor · plasminogen activator · tissue inhibitor of metalloproteinase 1 · tissue inhibitor of metalloproteinase 1 amino terminal fragment of urokinase type plasminogen activator bovine pancreas trypsin inhibitor · unclassified drug · urokinase receptor · animal cell · animal experiment · animal model · animal tissue · article · carotid artery · cell surface · controlled study · electroporation · expression vector · female · gene overexpression · gene targeting · genetic transfection · human · human tissue · hypercholesterolemia · in vivo culture · intima · male · mouse · nonhuman · nonviral gene delivery system · priority journal · vein graft disease
[Abstract]

6 Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation
article 2007    
Author: Bezooijen, R.L. van · Svensson, J.P. · Eefting, D. · Visser, A. · Horst, G. van der · Karperien, M. · Quax, P.H.A. · Vrieling, H. · Papapoulos, S.E. · Dijke, P. ten · Löwik, W.G.M.C.
Keywords: Biology · Biomedical Research · BMP · Bone formation · Microarray · Sclerostin · Signal transduction · SOST · Wnt · Bone morphogenetic protein · Dickkopf 1 protein · Glycoprotein · Growth factor · Protein inhibitor · Sclerostin · Wnt protein · Animal cell · Animal experiment · Animal tissue · Bone disease · Bone mass · Cell differentiation · Controlled study · DNA microarray · Electroporation · Embryo · Expression vector · Gastrocnemius muscle · Gene · Gene expression profiling · Gene targeting · Genetic transcription · Human · Human cell · In vivo study · Male · Mouse · Nonhuman · Ossification · Osteoblast · Osteocyte · Osteosclerosis · Protein family · Reporter gene · Signal transduction · SOST gene · Van buchem disease · Animals · Bone Development · Bone Morphogenetic Proteins · Cells, Cultured · Electroporation · Gene Expression Regulation · Genes, Reporter · Genetic Markers · Humans · Mesoderm · Mice · Muscle, Skeletal · Oligonucleotide Array Sequence Analysis · Recombinant Proteins · Signal Transduction · Transfection · Wnt Proteins
[Abstract]

7 Prolonged in vivo gene silencing by electroporation-mediated plasmid delivery of small interfering RNA
article 2007    
Author: Eefting, D. · Grimbergen, J.M. · Vries, M.R. de · Weel, V. van · Kaijzel, E.L. · Que, I. · Moon, R.T. · Löwik, C.W. · Bockel, J.H. van · Quax, P.H.A.
Keywords: Biology · Biomedical Research · double stranded RNA · histidine · luciferase · oligonucleotide · plasmid vector · small interfering RNA · toll like receptor 4 · uridine · animal cell · animal experiment · article · bioluminescence · controlled study · electroporation · gastrocnemius muscle · gene expression · gene function · gene repression · gene silencing · human · human cell · immune response · in vivo gene transfer · in vivo study · male · mouse · nonhuman · nonviral gene delivery system · protein expression · restenosis · RNA interference · transgene · treatment planning · tumor · viral gene delivery system · Animals · Cattle · Cell Line, Transformed · Cell Transformation, Viral · Electroporation · Feasibility Studies · Gene Silencing · Genes, Reporter · Humans · Hypoxanthine Phosphoribosyltransferase · Lipopolysaccharides · Luciferases · Luminescent Measurements · Male · Mice · Mice, Inbred Strains · Muscle, Skeletal · NIH 3T3 Cells · Plasmids · RNA Interference · RNA, Messenger · RNA, Small Interfering · Time Factors · Toll-Like Receptor 4 · Murinae
[Abstract]

8 Natural killer cells and CD4+ T-cells modulate collateral artery development
article 2007    
Author: Weel, V. van · Toes, R.E.M. · Seghers, L. · Deckers, M.M.L. · Vries, M.R. de · Eilers, P.H. · Sipkens, J. · Schepers, A. · Eefting, D. · Hinsbergh, V.W.M. van · Bockel, J.H. van · Quax, P.H.A.
Keywords: Biomedical Research · Angiogenesis · Animal models of human disease · Peripheral vascular disease · biological marker · CD3 antigen · CD4 antigen · vascularization · Animals · Arterial Occlusive Diseases · CD4-Positive T-Lymphocytes · Collateral Circulation · Disease Models, Animal · Femoral Artery · Hindlimb · Ischemia · Killer Cells, Natural · Mice · Mice, Inbred BALB C · Mice, Knockout · Neovascularization, Physiologic
[Abstract]

9 The effect of interleukin-10 knock-out and overexpression on neointima formation in hypercholesterolemic APOE*3-Leiden mice
article 2007    
Author: Eefting, D. · Schepers, A. · Vries, M.R. de · Pires, N.M.M. · Grimbergen, J.M. · Lagerweij, T. · Nagelkerken, L.M. · Monraats, P.S. · Jukema, J.W. · Bockel, J.H. van · Quax, P.H.A.
Keywords: Biology · Biomedical Research · Animal models · Cytokines · Electroporation · Gene therapy · In vivo delivery · Inflammation · Restenosis · cytokine · interleukin 10 · animal experiment · animal model · article · cholesterol blood level · controlled study · electroporation · experimental model · gene overexpression · gene transfer · hypercholesterolemia · immunohistochemistry · inflammation · intima · male · morphometrics · mouse · nonhuman · priority journal · restenosis · reverse transcription polymerase chain reaction · RNA isolation · Animals · Disease Models, Animal · Hypercholesterolemia · Interleukin-10 · Mice · Mice, Knockout · Tunica Intima · Vascular Diseases
[Abstract]

10 Anti-MCP-1 gene therapy inhibits vascular smooth muscle cells proliferation and attenuates vein graft thickening both in vitro and in vivo
article 2006    
Author: Schepers, A. · Eefting, D. · Bonta, P.I. · Grimbergen, J.M. · Vries, M.R. de · Weel, V. van · Vries, C.J. de · Egashira, K. · Bockel, J.H. van · Quax, P.H.A.
Keywords: Biology · Biomedical Research · Inflammation · Intimal hyperplasia · MCP-1 · Smooth muscle cells · Vein graft disease · Apolipoprotein E · Chemokine receptor CCR2 · Monocyte chemotactic protein 1 · Animal experiment · Animal model · Animal tissue · Artery intima proliferation · Atherosclerosis · Carotid artery · Cell proliferation · Controlled study · Graft failure · Human · Human cell · Human tissue · Hypercholesterolemia · In vitro study · In vivo study · Monocyte · Mouse · Nonhuman · Protein expression · Saphenous vein · Vascular smooth muscle · Vein graft · Amino Acid Sequence · Animals · Carotid Arteries · Cell Proliferation · Cells, Cultured · Chemokine CCL2 · Gene Therapy · Humans · Hypercholesterolemia · Male · Mice · Mice, Inbred C57BL · Muscle, Smooth, Vascular · Myocytes, Smooth Muscle · Organ Culture Techniques · Receptors, Chemokine · Saphenous Vein · Sequence Deletion · Tunica Intima
[Abstract]

11 Interleukin 10: A new risk marker for the development of restenosis after percutaneous coronary intervention
article 2007    
Author: Monraats, P.S. · Kurreeman, F.A.S. · Pons, D. · Sewgobind, V.D.K.D. · Vries, F.R. de · Zwinderman, A.H. · Maat, M.P.M. de · Doevendans, P.A. · Winter, R.J. de · Tio, R.A. · Waltenberger, J. · Huizinga, T.W.J. · Eefting, D. · Quax, P.H.A. · Frants, R.R. · Laarse, A. van der · Wall, E.E. van der · Jukema, J.W.
Keywords: Health · Biomedical Research · alanine · clopidogrel · cysteine · glycine · interleukin 10 · ticlopidine · adult · aged · article · cardiovascular risk · confidence interval · controlled study · coronary artery bypass graft · disease marker · DNA flanking region · DNA microarray · drug eluting stent · female · gene linkage disequilibrium · gene locus · genetic association · genetic polymorphism · genetic predisposition · genetic risk · genetic variability · genotype · heart infarction · human · hypothesis · in-stent restenosis · major clinical study · male · pathogenesis · percutaneous coronary intervention · priority journal · risk factor · 3' Untranslated Regions · Aged · Angioplasty, Transluminal, Percutaneous Coronary · Coronary Restenosis · Female · Genetic Predisposition to Disease · Genotype · Humans · Inflammation · Interleukin-10 · Male · Middle Aged · Polymorphism, Genetic · Promoter Regions (Genetics) · Prospective Studies · Risk Factors · Treatment Outcome
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 11 of 11 found. | Sort by date