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1 Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice
article 2006    
Author: Korsheninnikova, E. · Zon, G.C.M. van der · Voshol, P.J. · Janssen, G.M. · Havekes, L.M. · Grefhorst, A. · Kuipers, F. · Reijngoud, D.-J. · Romijn, J.A. · Ouwens, D.M. · Maassen, J.A.
Keywords: Biology · Biomedical Research · Hepatic steatosis · High-fat feeding · Nutrient sensing · Enzyme inhibitor · Glucose · Hydroxymethylglutaryl coenzyme A reductase kinase · Mammalian target of rapamycin · Protein kinase B · Protein S6 · S6 kinase · Tetradecylglycidic acid · Unclassified drug · Animal experiment · Animal model · Animal tissue · Controlled study · Diabetic obesity · Diabetogenesis · Enzyme activation · Glucose clamp technique · Hyperinsulinemia · Insulin resistance · Lipid diet · Liver homogenate · Liver mitochondrion · Mitochondrial membrane · Nonhuman · Nutrient concentration · Nutrient content · Protein blood level · Protein induction · Protein phosphorylation · Protein synthesis · Protein targeting · Species comparison · 1-Phosphatidylinositol 3-Kinase · Animals · Blood Glucose · Dietary Fats · DNA, Mitochondrial · Electron Transport Complex IV · Fatty Acids · Fatty Liver · Insulin · Insulin Resistance · Leucine · Liver · Male · Mice · Mice, Inbred C57BL · Phosphorylation · Protein Kinases · Ribosomal Proteins
[Abstract]

2 Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles
article 2002    
Author: Grefhorst, A. · Elzinga, B.M. · Voshol, P.J. · Plösch, T. · Kok, T. · Bloks, V.W. · Sluijs, F.H. van der · Havekes, L.M. · Romijn, J.A. · Verkade, H.J. · Kuipers, F.
Keywords: Animals · Anticholesteremic Agents · Apolipoproteins E · Carrier Proteins · Cell Line · DNA-Binding Proteins · Hypertriglyceridemia · Lipids · Lipoproteins, VLDL · Liver · Male · Membrane Proteins · Mice · Mice, Inbred C57BL · Phospholipid Transfer Proteins · Rats · Receptors, Cytoplasmic and Nuclear · Receptors, LDL · Receptors, Retinoic Acid · Receptors, Thyroid Hormone · Sulfonamides · Triglycerides · Animalia · Mus musculus
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