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1 Viability, function and morphological integrity of precision-cut liver slices during prolonged incubation: Effects of culture medium
article 2015    
Author: Starokozhko, V. · Abza, G.B. · Maessen, H.C. · Merema, M.T. · Kuper, F. · Groothuis, G.M.M.
Keywords: Biology · Precision-cut liver slices · Prolonged incubation · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · EELS - Earth, Environmental and Life Sciences
[Abstract]

2 The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo
article 2017    
Author: Li, M. · Graaf, I.A.M. de · Steeg, E. van de · Jager, M.H. de · Groothuis, G.M.M.
Keywords: Biology · CYP3A4 · Ex vivo · Interplay · P-glycoprotein · Precision-cut intestinal slice · Selective P-gp inhibitor · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

3 Evaluation of research activities and research needs to increase the impact and applicability of alternative testing strategies in risk assessment practice
article 2011    
Author: Punt, A. · Schiffelers, M.J.W.A. · Jean Horbach, G. · Sandt, J.J.M. van de · Groothuis, G.M.M. · Rietjens, I.M.C.M. · Blaauboer, B.J.
Keywords: Nutrition · Alternatives to animal testing · Genomics · In vitro testing · PBK modeling · QSAR · Reduction replacement refinement · Risk assessment · Stem cells · Three R's · Life · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences
[Abstract]

4 Corrigendum to ’Development of a mechanistic biokinetic model for hepatic bile acid handling to predict possible cholestatic effects of drugs’ [European Journal of Pharmaceutical Sciences 115 (2018) 175-184] (S0928098718300071) (10.1016/j.ejps.2018.01.007))
article 2018    
Author: Notenboom, S. · Weigand, K.M. · Proost, J.H. · Lipzig, M.M. van · Steeg, E. van de · Broek, P.H.H. van den · Greupink, R. · Russel, F.G.M. · Groothuis, G.M.M.
Keywords: Biology · Erratum · error · Life Triskelion BV · MSB - Microbiology and Systems Biology ADME - ADME/DMPK
[PDF] [Abstract]

5 Development of a mechanistic biokinetic model for hepatic bile acid handling to predict possible cholestatic effects of drugs
article 2018    
Author: Notenboom, S. · Weigand, K.M. · Proost, J.H. · Lipzig, M.M.H. van · Steeg, E. van de · Broek, P.H.H. van den · Greupink, R. · Russel, F.G.M. · Groothuis, G.M.M.
Keywords: Biology · Bile acid handling · Biokinetic model · BSEP · Cholestasis · Human · In silico · NTCP · Biomedical Innovation · Healthy Living · Life Triskelion BV · MSB - Microbiology and Systems Biology ADME - ADME/DMPK · ELSS - Earth, Life and Social Sciences TNO Bedrijven
[PDF] [Abstract]

Search results also available in MS Excel format.

Showing 1 to 5 of 5 found. | Sort by date