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1 Role of caveolin-1 in fibrotic diseases
article 2013    
Author: Gvaramia, D. · Blaauboer, M.E. · Hanemaaijer, R. · Everts, V.
Keywords: Biology · Caveolin-1 · CSD peptide · Fibrosis · Matrix remodeling · Mechanotransduction · TGF-β1 · Antifibrotic agent · Recombinant caveolin 1 · Transforming growth factor beta1 · Unclassified drug · Animal experiment · Animal model · Animal tissue · Controlled study · Human · Mechanical stress · Mouse · Nonhuman · Protein function · Short survey · Tissue repair · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

2 ERP organ-function on a chip in 2017
report 2018    
Author: Hanemaaijer, R. · Steeg, E. van de · Bobeldijk, I. · Ostendorf, R.
Keywords: Health · Predictive Health Technologies · Healthy Living · Life Healthy Living · MHR - Metabolic Health Research HL - Healthy for Life · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

3 Endothelial plasminogen activators and matrix metalloproteinases in fibrinolysis and local proteolysis
bookPart 1994    
Author: Hinsbergh, V.W.M. van · Hanemaaijer, R. · Koolwijk, P.
Keywords: Biology

4 Cyclic mechanical stretch reduces myofibroblast differentiation of primary lung fibroblasts
article 2011    
Author: Blaauboer, M.E. · Smit, T.H. · Hanemaaijer, R. · Stoop, R. · Everts, V.
Keywords: Health · Cyclic mechanical loading · Differentiation · Lung fibrosis · Myofibroblast · TGFβ1 · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

5 Erosive arthritis in a patient with pycnodysostosis: An experiment of nature
article 2008    
Author: Ainola, M. · Valleala, H. · Nykänen, P. · Risteli, J. · Hanemaaijer, R. · Konttinen, Y.T.
Keywords: Health · acid phosphatase tartrate resistant isoenzyme · calcitonin receptor · carboxy terminal telopeptide · cathepsin K · folic acid · hydroxychloroquine · ketoprofen · matrix metalloproteinase · messenger RNA · methotrexate · n [n (3 carboxyoxirane 2 carbonyl)leucyl]agmatine · prednisolone · salazosulfapyridine · adult · article · bone defect · bone erosion · case report · collagen degradation · controlled study · drug withdrawal · dysostosis · female · hand radiography · human · human cell · monocyte · multinuclear cell · nucleotide sequence · osteoclast · osteolysis · priority journal · psoriatic arthritis · pyknodysostosis · rash · synovitis · Acid Phosphatase · Arthritis, Psoriatic · Bone Resorption · Cathepsins · Cells, Cultured · Dysostoses · Female · Humans · Middle Aged · Monocytes · Osteoclasts · Receptors, Calcitonin
[Abstract]

6 Active MMPs captured by alpha2Macroglobulin as a marker of disease activity in rheumatoid arthritis
article 2003    
Author: Tchetverikov, I. · Verzijl, N. · Huizinga, T.W.J. · TeKoppele, J.M. · Hanemaaijer, R. · Groot, J. de
Keywords: Biology · Biomedical Research · α2Macroglobulin · Matrix metalloproteases · Rheumatoid arthritis · alpha 2 macroglobulin · batimastat · collagenase 3 · matrix metalloproteinase · tissue inhibitor of metalloproteinase 1 · article · circulation · clinical article · complex formation · concentration (parameters) · controlled study · correlation analysis · disease activity · disease course · disease marker · enzyme linked immunosorbent assay · erythrocyte sedimentation rate · fast protein liquid chromatography · fluorescence analysis · human · molecular weight · priority journal · protein analysis · protein blood level · quantitative analysis · rheumatoid arthritis · Adult · alpha-Macroglobulins · Arthritis, Rheumatoid · Biological Markers · Case-Control Studies · Disease Progression · Enzyme-Linked Immunosorbent Assay · Female · Humans · Male · Matrix Metalloproteinases · Middle Aged · Probability · Prognosis · Reference Values · Sensitivity and Specificity · Severity of Illness Index
[PDF] [Abstract]

7 Matrix metalloproteinase-9 measured in urine from bladder cancer patients is an independent prognostic marker of poor survival
article 2010    
Author: Offersen, B.V. · Knap, M.M. · Horsman, M.R. · Verheijen, J. · Hanemaaijer, R. · Overgaard, J.
Keywords: Health · Biomedical Research · creatinine · gelatinase B · adult · aged · article · bladder cancer · cancer mortality · cancer size · cancer survival · clinical assessment · correlation analysis · creatinine blood level · diagnostic value · female · human · major clinical study · male · overall survival · predictive validity · priority journal · prognosis · urinalysis
[Abstract]

8 Determination of Gelatinase-B (MMP-9) activity using a novel immunocapture assay in comparison with specific elisas
article 1999    
Author: Capper, S. · Evans, V. · Hanemaaijer, R. · Sully, M. · Verheijen, J. · Visser, H.
Keywords: Biology
[Abstract]

9 The composition of collagen in the aneurysm wall of men and women
article 2017    
Author: Villard, C. · Eriksson, P. · Hanemaaijer, R. · Lindeman, J.H. · Hultgren, R.
Keywords: Biology · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

10 Key Inflammatory Processes in Human NASH Are Reflected in Ldlr−/−.Leiden Mice: A Translational Gene Profiling Study
article 2018    
Author: Morrison, M.C. · Kleemann, R. · Koppen, A. van · Hanemaaijer, R. · Verschuren, L.
Keywords: Biology · Liver · NASH, · Inflammation · Molecular · Gene expression · Translational · Mouse · Human · Translational · Cytokine · Growth factor · Transcription factor · Animal experiment · Animal model · Controlled study · Extracellular matrix · Gene expression profiling · Human tissue · Inflammation · Lipid diet · Lipid metabolism · Liver biopsy · Mouse · Nonalcoholic fatty liver · Nonhuman · Transcriptomics · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

11 A novel and simple immunocapture assay for determination of gelatinase-B (MMP-9) activities in biological fluids : Saliva from patients with Sjögren's syndrome contain increased latent and active gelatinase-B levels
article 1998    
Author: Hanemaaijer, R. · Visser, H. · Konttinen, Y.T. · Koolwijk, P. · Verheijen, J.H.
Keywords: Health · Activity assay · Gelatinase B · Matrix metalloproteinases (MMP) · Sjogren's syndrome · Urokinase · Animals · Antibodies, Monoclonal · Antibody Specificity · Collagenases · Female · Humans · Immunoassay · Matrix Metalloproteinase 9 · Mice · Mice, Inbred BALB C · Saliva · Sensitivity and Specificity · Sjogren's Syndrome · Tissue Inhibitor of Metalloproteinase-2 · Animalia
[Abstract]

12 Gingival tissue and crevicular fluid co-operation in adult periodontitis
article 2006    
Author: Beklen, A. · Tüter, G. · Sorsa, T. · Hanemaaijer, R. · Virtanen, I. · Tervahartiala, T. · Konttinen, Y.T.
Keywords: Health · Collagenase · Gelatinase · Periodontitis · Stromelysin · collagenase · enzyme precursor · gelatinase · gelatinase B · metalloproteinase · neutrophil collagenase · procollagenase · progelatinase · stromelysin · adult · article · cell culture · enzyme activation · enzymology · female · fibroblast · gingiva · gingivitis · human · immunohistochemistry · male · middle aged · pathology · periodontitis · Adult · Cells, Cultured · Collagenases · Enzyme Activation · Enzyme Precursors · Female · Fibroblasts · Gelatinases · Gingiva · Gingival Crevicular Fluid · Humans · Immunohistochemistry · Male · Matrix Metalloproteinase 3 · Matrix Metalloproteinase 8 · Matrix Metalloproteinase 9 · Metalloendopeptidases · Middle Aged · Periodontitis
[Abstract]

13 Inhibition of urokinase-type and tissue-type plasminogen activator - Mediated plasminogen activation by doxycycline
article 1996    
Author: Hanemaaijer, R. · Visser, H. · Hoogen, C.M. van den · Sorsa, T. · Hinsbergh, V.W.M. van
Keywords: Biology · doxycycline · tissue plasminogen activator · urokinase · conference paper · fibrinolysis · human · plasminogen activation · priority journal
[Abstract]

14 MMP-9 and MMP-2 activities in stomach and breast tumours, as measured by a novel MMP activity assay using modified urokinase as a substrate
article 1998    
Author: Hanemaaijer, R. · Visser, H. · Duffy, J. · Verspaget, H.W. · Verheijen, J.H. · Maguire, T.
Keywords: Health
[Abstract]

15 Inhibition of matrix metalloproteinases by bisphosphonates may in part explain their effects in the treatment of multiple myeloma [6]
article 2000    
Author: Teronen, O. · Laitinen, M. · Salo, T. · Hanemaaijer, R. · Heikkilä, P. · Konttinen, Y.T. · Sorsa, T.
Keywords: Pharmacology · Antineoplastic Agents · Breast Neoplasms · Diphosphonates · Down-Regulation · Enzyme Inhibitors · Female · Humans · Male · Matrix Metalloproteinases · Multiple Myeloma · Neoplasm Metastasis

16 Leflunomide and methotrexate reduce levels of activated matrix metalloproteinases in complexes with α2 macroglobulin in serum of rheumatoid arthritis patients
article 2008    
Author: Tchetverikov, I. · Kraan, M.C. · El, B. van · Hanemaaijer, R. · Groot, J. de · Huizinga, T.W.J.
Keywords: Biology · Biomedical Research · alpha 2 macroglobulin · C reactive protein · leflunomide · matrix metalloproteinase · methotrexate · teriflunomide · tissue inhibitor of metalloproteinase 1 · analysis · blood sampling · clinical study · complex formation · controlled study · disease activity · drug activity · drug dose increase · drug effect · drug efficacy · drug exposure · loading drug dose · major clinical study · priority journal · protein blood level · quantitative analysis · rheumatoid arthritis · serum · systemic circulation · Aged · alpha-Macroglobulins · Antirheumatic Agents · Arthritis, Rheumatoid · Biological Markers · C-Reactive Protein · Down-Regulation · Enzyme Inhibitors · Female · Humans · Isoxazoles · Male · Matrix Metalloproteinases · Methotrexate · Middle Aged · Multiprotein Complexes · Phenylalanine · Statistics, Nonparametric · Thiophenes
[Abstract]

17 Doxycycline therapy for abdominal aneurysm: Improved proteolytic balance through reduced neutrophil content
article 2009    
Author: Abdul-Hussien, H. · Hanemaaijer, R. · Verheijen, J.H. · Bockel, J.H. van · Geelkerken, R.H. · Lindeman, J.H.N.
Keywords: Biology · Biomedical Research · antihypertensive agent · antithrombocytic agent · cystatin C · cysteine proteinase · doxycycline · gelatinase B · hydroxymethylglutaryl coenzyme A reductase inhibitor · messenger RNA · neutrophil collagenase · stromelysin · tissue inhibitor of metalloproteinase 1 · abdominal aorta aneurysm · adult · aged · aorta wall · article · clinical article · clinical trial · controlled clinical trial · controlled study · dose response · drug effect · drug megadose · drug tolerability · enzyme activity · enzyme assay · female · gene expression · human · human tissue · immunohistochemistry · low drug dose · male · neutrophil · polymerase chain reaction · priority journal · protein degradation · quantitative analysis · randomized controlled trial · treatment duration · Western blotting · Aged · Aged, 80 and over · Aorta, Abdominal · Aortic Aneurysm, Abdominal · Cardiovascular Agents · Cystatin C · Cysteine Endopeptidases · Dose-Response Relationship, Drug · Doxycycline · Female · Gene Expression Regulation, Enzymologic · Humans · Male · Matrix Metalloproteinases · Middle Aged · Neutrophil Infiltration · Neutrophils · Prospective Studies · Protease Inhibitors · RNA, Messenger · Time Factors · Tissue Inhibitor of Metalloproteinase-1 · Treatment Outcome · Vascular Surgical Procedures
[Abstract]

18 The pathophysiology of abdominal aortic aneurysm growth: Corresponding and discordant inflammatory and proteolytic processes in abdominal aortic and popliteal artery aneurysms
article 2010    
Author: Abdul-Hussien, H. · Hanemaaijer, R. · Kleemann, R. · Verhaaren, B.F.J. · Bockel, J.H. van · Lindeman, J.H.N.
Keywords: Biology
[Abstract]

19 Novel combination of collagen dynamics analysis and transcriptional profiling reveals fibrosis-relevant genes and pathways
article 2013    
Author: Blaauboer, M.E. · Emson, C.L. · Verschuren, L. · Erk, M. van · Turner, S.M. · Everts, V. · Hanemaaijer, R. · Stoop, R.
Keywords: Biology · Bleomycin · Cell proliferation · Extracellular matrix · Gene expression · Lung fibrosis · New collagen formation · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research MSB - Microbiology and Systems Biology · EELS - Earth, Environmental and Life Sciences
[Abstract]

20 Urinary matrix metalloproteinases reflect renal damage in anti-neutrophil cytoplasm autoantibody-associated vasculitis
article 2007    
Author: Sanders, J.S.F. · Huitema, M.G. · Hanemaaijer, R. · Goor, H. van · Kallenberg, C.G.M. · Stegeman, C.A.
Keywords: Biology · ANCA-associated vasculitis · Crescentic glomerulonephritis · Immunohistochemistry · MMP-2 · MMP-9 · Plasma levels · TIMP-1 · Urinary levels · C reactive protein · Adult · Aged · Aged, 80 and over · Antibodies, Antineutrophil Cytoplasmic · C-Reactive Protein · Creatine · Enzyme-Linked Immunosorbent Assay · Female · Humans · Immunohistochemistry · Kidney Diseases · Kidney Glomerulus · Male · Matrix Metalloproteinases · Middle Aged · Proteinuria · Tissue Inhibitor of Metalloproteinase-1 · Vasculitis
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 63 found. Next | Sort by date