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Showing 1 to 15 of 15 found. | Sort by date

1 Dose-response relationships and threshold levels in skin and respiratory allergy
article 2006    
Author: Arts, J.H.E. · Mommers, C. · Heer, C.de
Keywords: Health · Toxicology and Applied Pharmacology · Dose-Response · Elicitation · Respiratory Allergy · Sensitization · Skin Allergy · 1 chloro 2,4 dinitrobenzene · 1 fluoro 2,4 dinitrobenzene · acid anhydride · aldehyde · benzocaine · bronopol · chlorocresol · cytokine · dichromate potassium · diethylamine · ethylene · eugenol · formaldehyde · geraniol · glutaraldehyde · immunoglobulin E antibody · isocyanic acid derivative · isoeugenol · kathon cg · linalool · methacrylic acid derivative · myristic acid isopropyl ester · nickel · oxazolone · phthalic anhydride · rubber · subtilisin · toluene diisocyanate · tuberculin · unindexed drug · airway obstruction · analytic method · antigen specificity · CD4+ T lymphocyte · clinical study · concentration (parameters) · Dermatophagoides farinae · Dermatophagoides pteronyssinus · dose response · expiratory flow · exposure · forced expiratory volume · guinea pig · human · hypersensitivity reaction · Langerhans cell · nonhuman · occupational asthma · occupational hazard · respiratory tract allergy · review · safety · sensitivity analysis · skin allergy · skin defect · skin irritation · skin sensitization · skin test · urticaria · Allergens · Animals · Dermatitis, Allergic Contact · Dose-Response Relationship, Drug · Guidelines · Humans · Molecular Weight · No-Observed-Adverse-Effect Level · Occupational Exposure · Respiratory Hypersensitivity · Risk Assessment · Skin Tests · Animalia · Cavia porcellus · Dermatophagoides farinae · Dermatophagoides pteronyssinus
[Abstract]

2 Local effects in the respiratory tract: Relevance of subjectively measured irritation for setting occupational exposure limits
article 2006    
Author: Arts, J.H.E. · Heer, C.de · Woutersen, R.A.
Keywords: Biology · Toxicology and Applied Pharmacology · Chemosensory effects · Odorous irritants · Olfactory stimulation · Respiratory tract · Acetone · Formaldehyde · Furfural · Sulfur dioxide · Animal experiment · Animal tissue · Breathing rate · Concentration response · Controlled study · Disease severity · Incidence · Information retrieval · Medical literature · Nonhuman · Nose irritation · Perceptive threshold · Questionnaire · Respiratory tract disease · Review · Validation process · Voluntary reporting · Air Pollutants, Occupational · Animals · Humans · Irritants · Occupational Diseases · Occupational Exposure · Odors · Respiratory System · Smell · Threshold Limit Values · Animalia
[Abstract]

3 Critical effect sizes in toxicological risk assessment : a comprehensive and critical evaluation
article 2001    
Author: Dekkers, S. · Heer, C. de · Rennen, M.A.J.
Keywords: Environment · Benchmark modelling · Critical effect size · Risk assessment
[Abstract]

4 Extrapolation for exposure duration in oral toxicity: A quantitative analysis of historical toxicity data
article 2004    
Author: Groeneveld, C.N. · Hakkert, B.C. · Bos, P.M.J. · Heer, C.de
Keywords: Chemistry Safety Health · Food and Chemical Risk Analysis · Assessment factors · Database-derived distributions · Historical database · Probability distributions · Risk assessment
[Abstract]

5 Within-animal variation as an indication of the minimal magnitude of the critical effect size for continuous toxicological parameters applicable in the benchmark dose approach
article 2006    
Author: Dekkers, S. · Telman, J. · Rennen, M.A.J. · Appel, M.J. · Heer, C.de
Keywords: Biology · Food and Chemical Risk Analysis · Adverse effect · Benchmark approach · Critical effect size · Within-animal variation · Benchmarking · Biodiversity · Data reduction · Error analysis · Parameter estimation · Risk assessment · Adverse effects · Benchmark approach · Critical effect size (CES) · Within-animal variation · Toxicity · Intraspecific variation · Rodent · Temporal variation · Toxicity · Variance analysis · Analysis of variance · Animal experiment · Circadian rhythm · Clinical chemistry · Controlled study · Effect size · Female · Hematology · Male · Nonhuman · Rat · Review · Sex difference · Toxicity testing · Toxicological parameters · Analysis of Variance · Animals · Data Interpretation, Statistical · Dogs · Dose-Response Relationship, Drug · Female · Male · Poisons · Rats · Rats, Wistar · Risk Assessment · Toxicology · Animalia
[Abstract]

6 Oral-to-inhalation route extrapolation in occupational health risk assessment: A critical assessment
article 2004    
Author: Rennen, M.A.J. · Bouwman, T. · Wilschut, A. · Bessems, J.G.M. · Heer, C.de
Keywords: Health Chemistry · Food and Chemical Risk Analysis · Inhalation · Local effects · Oral · Respiratory · Risk assessment · Route extrapolation · Accuracy · Analytical error · Data base · Inhalation · Intermethod comparison · Occupational exposure · Occupational hazard · Priority journal · Quantitative analysis · Reliability · Risk assessment · Screening test · Administration, Inhalation · Administration, Oral · Animals · Dose-Response Relationship, Drug · Humans · Models, Biological · No-Observed-Adverse-Effect Level · Occupational Exposure · Pesticides · Predictive Value of Tests · Research Design · Risk Assessment · Species Specificity
[Abstract]

7 Effects of single and repeated exposure to biocidal active substances on the barrier function of the skin in vitro
article 2005    
Author: Buist, H.E. · Sandt, J.J.M. van de · Burgsteden, J.A. van · Heer, C. de
Keywords: Chemistry Safety · Biomedical Research · Biocidal active substances · Dermal absorption · Quaternary ammonium chlorides · Repeated exposure · Risk assessment · Single exposure · Skin barrier · ammonium derivative · biocide · boric acid · deltamethrin · formaldehyde · permethrin · piperonyl butoxide · quaternary ammonium derivative · sodium bromide · tebuconazole · unclassified drug · water · adult · article · controlled study · dilution · exposure · female · human · human tissue · intermethod comparison · priority journal · quantitative analysis · risk assessment · skin absorption · skin function · skin penetration · skin permeability · statistical significance · titrimetry · Adult · Benzalkonium Compounds · Carbon Radioisotopes · Detergents · Deuterium Oxide · Dose-Response Relationship, Drug · Female · Humans · Middle Aged · Perfusion · Permeability · Propoxur · Quaternary Ammonium Compounds · Skin Absorption · Skin Physiology
[Abstract]

8 Categorization of health risks from exposure to active pharmaceutical ingredients = Categorisatie van bereidingsrisico's
article 2005    
Author: Tielemans, E. · Schaafsma, G. · Heer, C. de · Rijnders, E. · Groenewold, M. · Bouwman, Y.
Keywords: Safety Chemistry · Food and Chemical Risk Analysis · pyridoxine derivative · drug contamination · drug exposure · drug manufacture · health hazard · human · maximum allowable concentration · Netherlands · occupational exposure · short survey · toxicity

9 Dermatokinetics of didecyldimethylammonium chloride and the influence of some commercial biocidal formulations on its dermal absorption in vitro
article 2007    
Author: Buist, H.E. · Heer, C. de · Burgsteden, J.A. van · Sandt, J.J.M. van de
Keywords: Chemistry · Biomedical Research · Biocides · Dermal absorption · Dermatokinetics · Didecyldimethylammonium chloride · Quaternary ammonium chlorides · Repeated exposure · Risk assessment · Single exposure · Skin barrier · Vehicle effects · Aldehyde · Biocide · Didecyldimethylammonium chloride · Adult · Aqueous solution · Concentration (parameters) · Correlation analysis · Drug absorption · Drug distribution · Drug exposure · Drug formulation · Drug penetration · Epidermis · Female · Human · Human cell · Human tissue · In vitro study · Priority journal · Skin absorption · Skin permeability · Stratum corneum · Toxicokinetics · Administration, Cutaneous · Cells, Cultured · Chemistry, Pharmaceutical · Disinfectants · Humans · Kinetics · Permeability · Quaternary Ammonium Compounds · Skin Absorption · Tissue Distribution
[Abstract]

10 Inhaled formaldehyde: Evaluation of sensory irritation in relation to carcinogenicity
article 2006    
Author: Arts, J.H.E. · Rennen, M.A.J. · Heer, C.de
Keywords: Health · Toxicology and Applied Pharmacology · Benchmark dose · Carcinogenicity · Formaldehyde · Sensory irritation · formaldehyde · article · carcinogenicity · computer program · eye irritation · human · nonhuman · nose injury · nose irritation · odor · priority journal · rating scale · respiratory tract disease · sense organ · smelling · symptomatology · Administration, Inhalation · Air Pollutants · Animals · Carcinogens · Carcinoma · Eye · Formaldehyde · Humans · Inhalation Exposure · Irritants · Nasal Mucosa · No-Observed-Adverse-Effect Level · Nose Neoplasms · Occupational Exposure · Pharynx · Risk Assessment · Animalia
[Abstract]

11 Vß gene family usage in spontaneous lymphomas of AKR mice: evidence for defective clonal deletion
article 1992    
Author: Heer, C. de · Geus, B. de · Schuurman, H.J. · Loveren, H. van · Rozing, J.
Keywords: Biology
[Abstract]

12 Prediction of local irritant effects after repeated dermal and respiratory exposure to chemicals
article 2002    
Author: Rennen, M.A.J. · Nordheim, K. · Houben, G.F. · Heer, C. de
Keywords: Nutrition · Administration, Cutaneous · Animals · Databases, Factual · Disease Models, Animal · Humans · Inhalation Exposure · Irritants · Models, Theoretical · Occupational Exposure · Predictive Value of Tests · Respiratory System · Risk Assessment · Skin · Toxicity Tests
[Abstract]

13 Within-animal variation as a minimal critical effect size for continuous toxicological parameters applicable in the Benchmark dose approach (Extended Abstract)
article 2006    
Author: Dekkers, S. · Telman J. · Rennen, M.A.J. · Appel, M.J. · Buist, H.E. · Heer, C. de
Keywords: Biology · Food and Nutrition · Healthy Living

14 The SCID-hu mouse as a tool in immunotoxicological risk assessment: Effects of 2-acetyl-4(5)-tetrahydroxybutyl-imidazole (THI) and di-n-butyltin dichloride (DBTC) on the human thymus in SCID-hu mice
article 1995    
Author: Heer, C. de · Schuurman, H.J. · Houben, G.F. · Pieters, R.H.H. · Penninks, A.H. · Loveren, H. van
Keywords: Nutrition · Caramel colour III · Immunotoxicology · Organotins · Risk assessment · SCID-hu · Thymus · 2 acetyl 4 (1,2,3,4 tetrahydroxybutyl)imidazole · Dibutyltin dichloride · Food additive · Imidazole derivative · Animal experiment · Animal model · Animal tissue · Controlled study · Female · Histopathology · Immunotoxicity · Mouse · Nonhuman · Priority journal · Risk assessment · Thymus · Ammonia · Animal · Female · Food Coloring Agents · Human · Imidazoles · Immunosuppressive Agents · Mice · Mice, SCID · Organotin Compounds · Risk Assessment · Specific Pathogen-Free Organisms · Support, Non-U.S. Gov't · Teratogens · Thymus Gland · Animalia · Rodentia
[Abstract]

15 Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to the human thymus after implantation in SCID mice
article 1995    
Author: Heer, C. de · Schuurman, H.-J. · Liem, A.K.D. · Penninks, A.H. · Vos, J.G. · Loveren, H. van
Keywords: Toxicology

Search results also available in MS Excel format.

Showing 1 to 15 of 15 found. | Sort by date