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1 Pediatric Mïcrodose and Microtracer Studies Using 14C in Europe
article 2015    
Author: Turner, M.A. · Mooij, M.G. · Vaes, W.H.J. · Windhorst, A.D. · Hendrikse, N.H. · Knibbe, C.A.J. · Körgvee, L.T. · Maruszak, W. · Grynkiewicz, G. · Garner, R.C. · Tibbocl, D. · Park, B.K. · Wildt, S.N. de
Keywords: Nutrition · Carbon · Drug · Age · Dose calculation · Dose response · Drug-Related Side Effects and Adverse Reactions · Economics · Ethics · Legislation and jurisprudence · Metabolism · Newborn · Phase 1 clinical trial (topic) · Preschool child · Age Factors · Carbon Radioisotopes · Child · Child, Preschool · Clinical Trials, Phase I as Topic · Dose-Response Relationship, Drug · Drug Approval · Drug Costs · Drug Dosage Calculations · Drug-Related Side Effects and Adverse Reactions · Europe · Government Regulation · Humans · Infant · Infant, Newborn · Patient Safety · Pharmaceutical Preparations · Pharmacokinetics · Risk Assessment · Risk Factors · Food and Nutrition · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

2 Microdosing of a Carbon-14 Labeled Protein in Healthy Volunteers Accurately Predicts Its Pharmacokinetics at Therapeutic Dosages
article 2015    
Author: Vlaming, M.L. · Duijn, E. van · Dillingh, M.R. · Brands, R. · Windhorst, A.D. · Hendrikse, N.H. · Bosgra, S. · Burggraaf, J. · Koning, M.C. de · Fidder, A. · Mocking, J.A. · Sandman, H. · Ligt, R.A. de · Fabriek, B.O. · Pasman, W.J. · Seinen, W. · Alves, T. · Carrondo, M. · Peixoto, C. · Peeters, P.A. · Vaes, W.H.
Keywords: Biology · Alkaline phosphatase, placental · Carbon · Glycosylphosphatidylinositol anchored protein · Isoenzyme · Recombinant protein · Area under the curve · Biological model · Clinical trial · Controlled study · Dose calculation · Double blind procedure · Half life time · Intravenous drug administration · Phase 1 clinical trial · Procedures · Randomized controlled trial · Statistical model · Administration, Intravenous · Adolescent · Adult · Alkaline Phosphatase · Area Under Curve · Carbon Radioisotopes · Double-Blind Method · Drug Dosage Calculations · GPI-Linked Proteins · Half-Life · Healthy Volunteers · Humans · Isoenzymes · Linear Models · Male · Mass Spectrometry · Metabolic Clearance Rate · Models, Biological · Netherlands · Recombinant Proteins · Young Adult · Biomedical Innovation · Healthy Living · Life Triskelion BV · MSB - Microbiology and Systems Biology ARPC - Analytical Research (Pharm & Chemistry) · ELSS - Earth, Life and Social Sciences TNO Bedrijven
[Abstract]

3 Pediatric Microdose Study of [14C]Paracetamol to Study Drug Metabolism Using Accelerated Mass Spectrometry: Proof of Concept
article 2014    
Author: Mooij, M.G. · Duijn, E. van · Knibbe, C.A.J. · Windhorst, A.D. · Hendrikse, N.H. · Vaes, W.H.J. · Spaans, E. · Fabriek, B.O. · Sandman, H. · Grossouw, D. · Hanff, L.M. · Janssen, P.J.J.M. · Koch, B.C.P. · Tibboel, D. · Wildt, S.N. de
Keywords: Nutrition · Carbon 14 · Drug metabolite · Paracetamol · Accelerator mass spectrometry · Blood sampling · Child · Clinical article · Drug blood level · Drug metabolism · Female · Human · Indwelling catheter · Infant · Limit of quantitation · Liquid chromatography · Male · Mass spectrometry · Maximum plasma concentration · Newborn · Open study · Pharmacokinetics · Pilot study · Preschool child · Priority journal · Single drug dose · Time to maximum plasma concentration · Food and Nutrition · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

Search results also available in MS Excel format.

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