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Showing 1 to 6 of 6 found. | Sort by date

1 Modelling the responses to biological reactive intermediates : establishing the borderlines of risk
article 2001    
Author: Bladeren, P.J. van · Bogaards, J.J.P. · Cnubben, N.H.P. · Hissink, E.M.
Keywords: Biology

2 Hepatic epoxide concentrations during biotransformation of 1,2- and 1,4- dichlorobenzene: The use of in vitro and in vivo metabolism, kinetics and PB- PK modeling
article 1996    
Author: Hissink, E. · Ommen, B. van · Bogaards, J.J. · Bladeren, P.J. van
Keywords: Toxicology · 1,2 dichlorobenzene · 1,4 dichlorobenzene · alanine aminotransferase · ascorbic acid · cytochrome p450 isoenzyme · epoxide · glutathione · isoniazid · animal cell · animal experiment · animal model · biotransformation · conference paper · controlled study · detoxification · enzyme substrate · liver microsome · liver toxicity · male · mathematical model · nonhuman · priority journal · rat · toxicokinetics · Animals · Biotransformation · Carcinogens · Chlorobenzenes · Cytochrome P-450 Enzyme System · Epoxy Compounds · Humans · Liver · Male · Microsomes, Liver · Models, Biological · Rats · Rats, Wistar

3 Prediction of interindividual variation in drug plasma levels in vivo from individual enzyme kinetic data and physiologically based pharmacokinetic modeling
article 2000    
Author: Bogaards, J.J.P. · Hissink, E.M. · Briggs, M. · Weaver, R. · Jochemsen, R. · Jackson, P. · Bertrand, M. · Bladeren, P. van
Keywords: Nutrition · Cytochrome P450 · Interindividual variation · Metabolism · Physiologically based pharmacokinetic modeling · Agomelatine · Bufuralol · Chlorzoxazone · Coumarin · Cytochrome P450 · Diclofenac · Ethoxyresorufin · Mephenytoin · Testosterone · Clinical trial · Controlled clinical trial · Controlled study · Drug blood level · Enzyme kinetics · Food drug interaction · Genetic polymorphism · Human · Human cell · Human experiment · Human tissue · Liver microsome · Male · Model · Normal human · Phase 1 clinical trial · Phenotype · Priority journal · Acetamides · Cell Line · Cytochrome P-450 Enzyme System · Humans · Hypnotics and Sedatives · Isoenzymes · Kinetics · Microsomes, Liver · Models, Biological · Pharmaceutical Preparations · Pharmacokinetics · Recombinant Proteins · Transfection
[Abstract]

4 Computer-aided biokinetic modelling combined with in vitro data
article 1995    
Author: Ommen, B. van · Jongh, J. de · Sandt, J. van de · Blaauboer, B. · Hissink, E. · Bogaards, J. · Bladeren, P. van
Keywords: Toxicology · Animalia · Oryctolagus cuniculus · Sus scrofa
[Abstract]

5 The use of in vitro metabolic parameters and physiologically based pharmacokinetic (PBPK) modeling to explore the risk assessment of trichloroethylene
article 2002    
Author: Hissink, E.M. · Bogaards, J.J.P. · Freidig, A.P. · Commandeur, J.N.M. · Vermeulen, N.P.E. · Bladeren, P.J. van
Keywords: Environment · PBPK · Radioactivity · Trichloroethylene
[Abstract]

6 Increased bioactivation of dihaloalkanes in rat liver due to induction of class Theta glutathione S-transferase T1-1
article 1998    
Author: Sherratt, P.J. · Manson, M.M. · Thomson, A.M. · Hissink, E.A.M. · Neal, G.E. · Bladeren, P.J. van · Green, T. · Hayes, J.D.
Keywords: Nutrition · 3 indolemethanol · Alkane derivative · Antineoplastic agent · Cytochrome p450 · Glutathione transferase · Liver enzyme · Messenger rna · Phenobarbital · Animal tissue · Cancer prevention · Chemoprophylaxis · Controlled study · Cytoplasm · Diet · Enzyme subunit · Female · Immunoblotting · Male · Nonhuman · Priority journal · Rat · Animals · Anticarcinogenic Agents · Biotransformation · Carcinogens · Dietary Supplements · Enzyme Induction · Female · Glutathione Transferase · Humans · Hydrocarbons, Brominated · Isoenzymes · Liver · Male · Methylene Chloride · Phenobarbital · Rats · Rats, Inbred F344 · Sex Characteristics · Xenobiotics · Animalia
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 6 of 6 found. | Sort by date