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1 The CCR2 Inhibitor Propagermanium Attenuates Diet-Induced Insulin Resistance, Adipose Tissue Inflammation and Non-Alcoholic Steatohepatitis
article 2017    
Author: Mulder, P. · Hoek, A.M. van den · Kleenann, R.
Keywords: Biology · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

2 Leptin deficiency per se dictates body composition and insulin action in ob/ob mice
article 2008    
Author: Hoek, A.M. van den · Teusink, B. · Voshol, P.J. · Havekes, L.M. · Romijn, J.A. · Pijl, H.
Keywords: Biology · Adiposity hormone · Brain · Insulin resistance · Metabolism · Type 2 diabetes mellitus · glucose · insulin · leptin · animal experiment · animal tissue · article · body composition · body weight · caloric restriction · controlled study · diet restriction · female · gluconeogenesis · glucose clamp technique · glucose metabolism · hormone deficiency · insulin resistance · insulin sensitivity · lean body weight · leptin deficiency · male · mouse · mouse strain · nonhuman · obesity · pathophysiology · priority journal · quantitative analysis · signal transduction · wild type · Animals · Blood Glucose · Body Composition · Body Weight · Fatty Acids, Nonesterified · Female · Food Deprivation · Glucose · Glucose Clamp Technique · Growth and Development · Insulin · Leptin · Male · Mice · Mice, Inbred C57BL · Mice, Obese · Mice, Transgenic · Obesity
[Abstract]

3 Colestilan decreases weight gain by enhanced NEFA incorporation in biliary lipids and fecal lipid excretion
article 2013    
Author: Sugimoto-Kawabata, K. · Shimada, H. · Sakai, K. · Suzuki, K. · Kelder, T. · Pieterman, E.J. · Cohen, L.H. · Havekes, L.M. · Princen, H.M. · Hoek, A.M. van den
Keywords: Biology · Adipose tissue · Bile acid sequestrant · Hyperinsulinemic-euglycemic clamp · Insulin sensitivity · Nonesterified fatty acid · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

4 Aliskiren inhibits atherosclerosis development and improves plaque stability in APOE*3Leiden.CETP transgenic mice with or without treatment with atorvastatin
article 2012    
Author: Kühnast, S. · Hoorn, J.W.A. van der · Hoek, A.M. van den · Havekes, L.M. · Liau, G. · Jukema, J.W. · Princen, H.M.G.
Keywords: aliskiren · APOE*3Leiden.CETP mice · atherosclerosis · atorvastatin · hypertension · plaque stability · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

5 Intracerebroventricular administration of neuropeptide Y induces hepatic insulin resistance via sympathetic innervation
article 2008    
Author: Hoek, A.M. van den · Heijningen, C. van · Schröder - Elst, J.P. van der · Ouwens, D.M. · Havekes, L.M. · Romijn, J.A. · Kalsbeek, A. · Pijl, H.
Keywords: corticosterone · glucose · insulin · liothyronine · neuropeptide Y · testosterone · thyroxine · antidiabetic agent · animal experiment · animal model · animal tissue · article · controlled study · drug mechanism · glucose metabolism · hormone blood level · insulin resistance · liver · male · nonhuman · parasympathetic innervation · priority journal · rat · sympathetic innervation · adrenergic system · animal · drug effect · glucose blood level · glucose clamp technique · hyperinsulinism · innervation · intracerebroventricular drug administration · metabolism · pathophysiology · physiology · sympathectomy · vagotomy · Wistar rat · Animals · Blood Glucose · Glucose Clamp Technique · Hyperinsulinism · Hypoglycemic Agents · Injections, Intraventricular · Insulin · Insulin Resistance · Liver · Male · Neuropeptide Y · Parasympathectomy · Rats · Rats, Wistar · Sympathectomy · Sympathetic Nervous System
[Abstract]

6 Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology
article 2014    
Author: Liang, W. · Menke, A.L. · Driessen, A. · Koek, G.H. · Lindeman, J.H. · Stoop, R. · Havekes, L.M. · Kleemann., R. · Hoek, A.M. van den
Keywords: Biology · Adult · Animal experiment · Animal model · Clinical article · Controlled study · Female · Hepatitis · Histopathology · Human · Human tissue · Human versus animal comparison · Liver biopsy · Liver fibrosis · Liver hypertrophy · Macrovesicular steatosis · Male · Microvesicular steatosis · Nonalcoholic fatty liver · Nonhuman · Process development · Reproducibility · Scoring system · Steatosis · Validation process · Rodentia · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

7 Metabolically induced liver inflammation leads to NASH and differs from LPS-or IL-1β-induced chronic inflammation
article 2014    
Author: Liang, W. · Lindeman, J.H. · Menke, A.L. · Koonen, D.P. · Morrison, M. · Havekes, L.M. · Hoek, A.M. van den · Kleemann, R.
Keywords: Biology · human NASH · inflammation · neutrophils · NF-κB · steatosis · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

8 Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice
article 2005    
Author: Heijboer, A.C. · Hoek, A.M. van den · Pijl, H. · Voshol, P.J. · Havekes, L.M. · Romijn, J.A. · Corssmit, E.P.M.
Keywords: Biology · Biomedical Research · Brain · Diabetes · Glut4 · Insulin resistance · Metabolism · Neuropeptides · Glucose transporter 4 · Hormone receptor stimulating agent · Insulin · Melanocortin 3 receptor · Melanocortin 4 receptor · Melanotan II · Messenger RNA · Placebo · Tritium · Unclassified drug · Water · Animal experiment · Animal tissue · Body weight · Brain lateral ventricle · Controlled study · Distillation · Drug effect · Food intake · Gluconeogenesis · Glucose blood level · Glucose clamp technique · Glucose metabolism · Hyperinsulinemia · Insulin sensitivity · Isotope labeling · Mouse · Mouse strain · Nonhuman · Skeletal muscle · Alpha-MSH · Animals · Blood Glucose · Corticosterone · Fatty Acids, Nonesterified · Glucose · Glucose Clamp Technique · Glucose Transporter Type 4 · Injections, Intraventricular · Insulin · Insulin Resistance · Kinetics · Liver · Male · Mice · Mice, Inbred C57BL · Monosaccharide Transport Proteins · Muscle Proteins · Peptides, Cyclic · Receptor, Melanocortin, Type 3 · Receptor, Melanocortin, Type 4 · RNA, Messenger
[Abstract]

9 Ghrelin differentially affects hepatic and peripheral insulin sensitivity in mice
article 2006    
Author: Heijboer, A.C. · Hoek, A.M. van den · Parlevliet, E.T. · Havekes, L.M. · Romijn, J.A. · Pijl, H. · Corssmit, E.P.M.
Keywords: Biology · Biomedical Research · Animal models · GHRP-6 · Glucose metabolism · Gut hormone · Hyperinsulinaemic- euglycaemic clamp technique · Insulin resistance · Tracer methodology · Deoxyglucose · Desoctanoylghrelin · Ghrelin · Growth hormone secretagogue receptor · Growth hormone secretagogue receptor stimulating agent · Histidyl dextro tryptophylalanyltryptophyl dextro phenylalanyllysinamide · Peptide derivative · Unclassified drug · Adipose tissue · Adolescent · Body weight · Controlled study · Food intake · Glucogenesis · Glucose clamp technique · Glucose metabolism · Hormone action · Hyperinsulinemia · Insulin sensitivity · Isotope dilution assay · Liver metabolism · Mouse · Muscle metabolism · Nonhuman · Animals · Body Weight · Glucose · Hepatocytes · Insulin · Male · Mice · Mice, Inbred C57BL · Peptide Hormones
[Abstract]

10 Overexpression of APOC1 in obob mice leads to hepatic steatosis and severe hepatic insulin resistance
article 2004    
Author: Muurling, M. · Hoek, A.M. van den · Mensink, R.P. · Pijl, H. · Romijn, J.A. · Havekes, L.M. · Voshol, P.J.
Keywords: Biology · Biomedical Research · Free fatty acid metabolism · Hepatic fat accumulation · Lipid metabolism · Peroxisome proliferator-activated receptor-γ · Rosiglitazone · Diacylglycerol · Glucose · Ketone body · Peroxisome proliferator activated receptor gamma · Rosiglitazone · Triacylglycerol · Adipose tissue · Animal experiment · Animal model · Animal tissue · APOC1 gene · Cholesterol blood level · Controlled study · Fatty acid metabolism · Gene · Gene overexpression · Gluconeogenesis · Glucose blood level · Glucose transport · Hyperglycemia · Hyperinsulinemia · Hyperlipidemia · Insulin blood level · Insulin resistance · Lipid metabolism · Lipid storage · Mouse · Nonhuman · Obesity · Transgenic mouse · Triacylglycerol blood level · Weight reduction · Animals · Apolipoprotein C-I · Apolipoproteins C · Blood Glucose · Body Weight · Fatty Acids · Fatty Liver · Gene Expression · Humans · Hyperglycemia · Hyperinsulinism · Hyperlipidemias · Insulin · Insulin Resistance · Mice · Mice, Transgenic
[PDF] [Abstract]

11 Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin
article 2014    
Author: Kühnast, S. · Hoorn, J.W.A. van der · Pieterman, E.J. · Hoek, A.M. van den · Sasiela, W.J. · Gusarova, V. · Peyman, A. · Schäfer, H.L. · Schwahn, U. · Jukema, J.W. · Princen, H.M.G.
Keywords: Biology · 3Leiden.CETP mice · APOE · Atorvastatin · Proprotein convertase subtilisin/kexin type 9 · Alirocumab · Apolipoprotein E · Atorvastatin · Bile acid · Cholesterol · Collagen · Low density lipoprotein receptor · Sterol · Triacylglycerol · Animal experiment · Animal model · Atherosclerosis · Atherosclerotic plaque · Controlled study · Disease severity · Dose response · Drug effect · Drug potentiation · Drug safety · Fat content · Female · Lipid blood level · Monocyte · Monotherapy · Mouse · Nonhuman · Protein degradation · Smooth muscle fiber · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

12 CETP does not affect triglyceride production or clearance in APOE*3-Leiden mice
article 2010    
Author: Bijland, S. · Berg, S.A.A. van den · Voshol, P.J. · Hoek, A.M. van den · Princen, H.M.G. · Havekes, L.M. · Rensen, P.C.N. · Dijk, K.W. van
Keywords: Biology · Food and Chemical Risk Analysis · Cholesteryl ester transfer protein · HDL · Postprandial lipoproteins · Triglyceride metabolism
[PDF] [Abstract]

13 Plasma and liver lipidomics response to an intervention of rimonabant in ApoE*3Leiden.CETP transgenic mice
article 2011    
Author: Hu, C. · Wei, H. · Hoek, A.M. van den · Wang, M. · Heijden, R. van der · Spijksma, G. · Reijmers, T.H. · Bouwman, J. · Wopereis, S. · Havekes, L.M. · Verheij, E. · Hankemeier, T. · Xu, G. · Greef, J. van der
Keywords: Health · Life · MHR - Metabolic Health Research MSB - Microbiology and Systems Biology · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

14 Circulating insulin stimulates fatty acid retention in white adipose tissue via KATP channel activation in the central nervous System only in insulin-sensitive mice
article 2011    
Author: Coomans, C.P. · Geerling, J.J. · Guigas, B. · Hoek, A.M. van den · Parlevliet, E.T. · Ouwens, D.M. · Pijl, H. · Voshol, P.J. · Rensen, P.C.N. · Havekes, L.M. · Romijn, J.A.
Keywords: Health Biology · Brain · Brown adipose tissue · Insulin resistance · Lipid metabolism · Lipoprotein lipase · Triglycerides · adenosine triphosphate sensitive potassium channel · CD36 antigen · cyclic AMP · fatty acid · insulin · leptin · serum albumin · tolbutamide · triacylglycerol · animal experiment · animal model · animal tissue · brown adipose tissue · central nervous system · channel gating · controlled study · drug administration route · drug distribution · drug half life · drug targeting · fatty acid metabolism · fatty acid retention · hormone action · hyperinsulinemia · insulin action · insulin sensitivity · male · mouse · nonhuman · signal transduction · white adipose tissue · wild type · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

15 A novel EPO receptor agonist improves glucose tolerance via glucose uptake in skeletal muscle in a mouse model of diabetes
article 2011    
Author: Scully, M.S. · Ort, T.A. · James, I.E. · Bugelski, P.J. · Makropoulos, D.A. · Deutsch, H.A. · Pieterman, E.J. · Hoek, A.M. van den · Havekes, L.M. · Dubell, W.H. · Wertheimer, J.D. · Picha, K.M.
Keywords: Health · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

16 Time-resolved and tissue-specific systems analysis of the pathogenesis of insulin resistance.
article 2010    
Author: Kleemann, R. · Erk, M. van · Verschuren, L. · Hoek, A.M. van den · Koek, M. · Wielinga, P.Y. · Jie, A. · Pellis, L. · Bobeldijk-Pastorova, I. · Kelder, T. · Toet, K. · Wopereis, S. · Cnubben, N. · Evelo, C. · Ommen, B. van · Kooistra, T.
Keywords: Biology · Biomedical Research · Apolipoprotein E3 · Fatty acid · Blood · DNA microarray · Genetics · Obesity · physiology · transgenic mouse · Western blotting · Adiposity · Animals · Apolipoprotein E3 · Blotting, Western · Fatty Acids, Nonesterified · Glucose Tolerance Test · Insulin Resistance · Male · Mice · Mice, Transgenic · Oligonucleotide Array Sequence Analysis · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research MSB - Microbiology and Systems Biology · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

17 Coordinated and Interactive Expression of Genes of Lipid Metabolism and Inflammation in Adipose Tissue and Liver during Metabolic Overload
article 2013    
Author: Liang, W. · Tonini, G. · Mulder, P. · Kelder, T. · Erk, M. van · Hoek, A.M. van den · Mariman, R. · Wielinga, P.Y. · Baccini, M. · Kooistra, T. · Biggeri, A. · Kleemann, R.
Keywords: Biology · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

18 The APOE∗3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis
article 2019    
Author: Pouwer, M.G. · Heinonen, S.E. · Behrendt, M. · Andréasson, A.M. · Koppen A. van · Menke, A.L. · Pieterman, E.J. · Hoek, A.M. van den · Jukema, J.W. · Leighton, B. · Jonsson-Rylander, A.M. · Princen, H.M.G.
Keywords: Health · Inflammatory diseases · Diabetes · Atherosclerosis · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

19 APOE*3Leiden.CETP transgenic mice as model for pharmaceutical treatment of the metabolic syndrome
article 2014    
Author: Hoek, A.M. van den · Hoorn, J.W.A. van der · Maas, A.C. · Hoogen, R.M. van den · Nieuwkoop, A. van · Droog, S. · Offerman, E.H. · Pieterman, E.J. · Havekes, L.M. · Princen, H.M.G.
Keywords: Biology · Diabetic dyslipidemia · Insulin resistance · NAFLD · Obesity · Pharmacological treatment · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

20 Metformin lowers plasma triglycerides by promoting vldl-triglyceride clearance by brown adipose tissue in mice
article 2014    
Author: Geerling, J.J. · Boon, M.R. · Zon, G.C. van der · Berg, S.A.A. van den · Hoek, A.M. van den · Lombès, M. · Princen, H.M.G. · Havekes, L.M. · Rensen, P.C.N. · Guigas, B.
Keywords: Biology · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 32 found. Next | Sort by date