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Showing 1 to 11 of 11 found. | Sort by date

1 Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL
article 2005    
Author: Berbée, J.F.P. · Hoogt, C.C. van der · Sundararaman, D. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · Apolipoprotein C-I · Fatty acids · Lipid metabolism · Lipoprotein lipase · Triglycerides · Very low density lipoprotein · Lipoprotein receptor · Tritium · Very low density lipoprotein · Animal experiment · Animal model · Cholesterol blood level · Controlled study · Enzyme activity · Half life time · Hyperlipidemia · Hyperlipoproteinemia type 3 · Lipolysis · Mouse · Nonhuman · Pathophysiology · Protein expression · Transgenic mouse · Animals · Apolipoproteins · Apolipoproteins C · Apolipoproteins E · Humans · Hypertriglyceridemia · Lactoferrin · Lipoproteins, VLDL · Liver · Mice · Mice, Inbred C57BL · Mice, Transgenic · Phenotype · Time Factors
[PDF] [Abstract]

2 Cholesteryl ester transfer protein decreases high-density lipoprotein and severely aggravates atherosclerosis in APOE*3-Leiden mice
article 2006    
Author: Westerterp, M. · Hoogt, C.C. van der · Haan, W. de · Offerman, E.H. · Dallinga-Thie, G.M. · Jukema, J.W. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Health · Biomedical Research · CETP · Cholesterol efflux · Hyperlipidemia · Reverse cholesterol transport · Transgenic mice cholesterol · High density lipoprotein · Low density lipoprotein · Very low density lipoprotein · Animal cell · Animal experiment · Animal model · Animal tissue · Aorta root · Atherosclerosis · Cholesterol blood level · Controlled study · Diet · Mouse · Nonhuman · Plasma · Protein expression · Transgenic mouse · Animals · Antigens, CD36 · Apolipoprotein E3 · Apolipoproteins E · Atherosclerosis · Carrier Proteins · Cell Line, Tumor · Cholesterol · Cholesterol Ester Transfer Proteins · Diet · Female · Glycoproteins · Humans · Lipids · Lipoproteins · Lipoproteins, HDL · Macrophages · Mice · Mice, Transgenic · Rats
[Abstract]

3 Cholesterol 7α-hydroxylase deficiency in mice on an APOE*3-Leiden background increases hepatic ABCA1 mRNA expression and HDL-cholesterol
article 2006    
Author: Post, S.M. · Groenendijk, M. · Hoogt, C.C. van der · Fievet, C. · Luc, G. · Hoekstra, M. · Princen, H.M.G. · Staels, B. · Rensen, P.C.N.
Keywords: Health · Biomedical Research · High-density lipoprotein · ABC transporter A1 · High density lipoprotein cholesterol · Intermediate density lipoprotein · Low density lipoprotein · Messenger RNA · Phosphatidylcholine sterol acyltransferase · Very low density lipoprotein · Bile acid · Phospholipid transfer protein · Phospholipid transfer protein, mouse · Animal experiment · Animal tissue · Bile acid synthesis · Biosynthesis · Catabolism · Cholesterol blood level · Cholesterol metabolism · cholesterol transport · Conhuman · Protein expression · Transgenic mouse · Genetics · Metabolism · Mouse · Mouse mutant · Physiology · Animals · Apolipoprotein E3 · ATP-Binding Cassette Transporters · Bile Acids and Salts · Cholesterol 7-alpha-Hydroxylase · Cholesterol, HDL · Female · Gene Expression Regulation · Gene Expression Regulation, Enzymologic · Humans · Liver · Mice · Mice, Knockout · Mice, Transgenic · Phosphatidylcholine-Sterol O-Acyltransferase · Phospholipid Transfer Proteins · RNA, Messenger
[Abstract]

4 Apolipoprotein CI stimulates the response to lipopolysaccharide and reduces mortality in gram-negative sepsis.
article 2006    
Author: Berbée, J.F. · Hoogt, C.C. van der · Kleemann, R. · Schippers, E.F. · Kitchens, R.L. · Dissel, J.T. van · Bakker-Woudenberg, I.A. · Havekes, L.M. · Rensen, P.C.
Keywords: Biology · Drug effect · Gram negative bacterium · Immunology · Mortality · Mouse · Mouse mutant · Nucleotide sequence · Transgenic mouse · Animals · Antigen Presentation · Apolipoprotein C-I · Apolipoproteins C · Binding Sites · Conserved Sequence · Gram-Negative Bacteria · Humans · Immunity · Inflammation · Lipopolysaccharides · Macrophages · Mice · Mice, Knockout · Mice, Transgenic · Sepsis
[Abstract]

5 Plasma apolipoprotein CI correlates with increased survival in patients with severe sepsis
article 2008    
Author: Berbée, J.F.P. · Hoogt, C.C. van der · Haas, C.J.C. de · Kessel, K.P.M. van · Dallinga-Thie, G.M. · Romijn, J.A. · Havekes, L.M. · Leeuwen, H.J. van · Rensen, P.C.N.
Keywords: Health · Physiological Sciences · Apolipoprotein · Bacteria · Intensive care · Lipoprotein · Mortality · Sepsis · apolipoprotein A1 · apolipoprotein C1 · apolipoprotein C3 · high density lipoprotein cholesterol · lipid · low density lipoprotein cholesterol · triacylglycerol · adult · article · blood sampling · cholesterol blood level · clinical article · controlled study · correlation analysis · disease severity · female · hospitalization · human · intensive care unit · lipid blood level · male · outcome assessment · prospective study · protein blood level · sepsis · survival · Aged · Apolipoprotein C-I · Biological Markers · Female · Humans · Male · Middle Aged · Prospective Studies · Sepsis · Survival Analysis · Healthy for Life · Healthy Living
[Abstract]

6 Fenofibrate increases HDL-cholesterol by reducing cholesteryl ester transfer protein expression
article 2007    
Author: Hoogt, C.C. van der · Haan, W. de · Westerterp, M. · Hoekstra, M. · Dallinga-Thie, G.M. · Romijn, J.A. · Princen, H.M.G. · Jukema, J.W. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Health · Biomedical Research · Fibrate · High density lipoprotein · Peroxisome proliferator-activated receptor α · Transgenic mice · apolipoprotein E · cholesterol ester transfer protein · fenofibrate · high density lipoprotein cholesterol · very low density lipoprotein · animal experiment · cholesterol transport · controlled study · drug mechanism · food intake · gene expression · lipid metabolism · mouse · nonhuman · priority journal · protein expression · protein function · steady state · transgene · Animals · Antilipemic Agents · Apolipoproteins B · Cholesterol Ester Transfer Proteins · Cholesterol Esters · Cholesterol, HDL · Gene Expression · Humans · Liver · Male · Mice · Mice, Transgenic · Procetofen · RNA, Messenger
[PDF] [Abstract]

7 Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden.CETP mice
article 2008    
Author: Haan, W. de · Hoogt, C.C. van der · Westerterp, M. · Hoekstra, M. · Dallinga-Thie, G.M. · Princen, H.M.G. · Romijn, J.A. · Jukema, J.W. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Health · CETP · High-density lipoprotein · HMGCoA reductase · Statin · Transgenic mice · ABC transporter A1 · apolipoprotein A1 · apolipoprotein E3 · atorvastatin · cholesterol ester transfer protein · high density lipoprotein · high density lipoprotein cholesterol · messenger RNA · phospholipid transfer protein · scavenger receptor BI · very low density lipoprotein · very low density lipoprotein cholesterol · animal experiment · animal model · article · cholesterol blood level · cholesterol diet · controlled study · drug effect · gene expression · hypercholesterolemia · lipoprotein blood level · lipoprotein metabolism · male · mouse · nonhuman · priority journal · protein expression · transgenic mouse · Animals · Apolipoprotein E3 · Cholesterol Ester Transfer Proteins · Cholesterol, Dietary · Cholesterol, HDL · Cholesterol, VLDL · Dose-Response Relationship, Drug · Female · Gene Expression · Heptanoic Acids · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Hypercholesterolemia · Liver · Male · Mice · Mice, Inbred C57BL · Mice, Transgenic · Pyrroles · RNA, Messenger
[Abstract]

8 ApoE2-associated hypertriglyceridemia is ameliorated by increased levels of apoA-V but unaffected by apoC-III deficiency
article 2008    
Author: Gerritsen, G. · Hoogt, C.C. van der · Schaap, F.G. · Voshol, P.J. · Kypreos, K.E. · Maeda, N. · Groen, A.K. · Havekes, L.M. · Rensen, P.C.N. · Dijk, K.W. van
Keywords: Health · Physiological Sciences · Adenovirus-mediated gene transfer · APOE2-knockin mice · Apolipoprotein A-V · Apolipoprotein C-III · Apolipoprotein E2 · Lipoprotein lipase-mediated very low density lipoprotein-triglyceride hydrolysis · apolipoprotein A · apolipoprotein A5 · apolipoprotein B · apolipoprotein C · apolipoprotein C3 · apolipoprotein D · apolipoprotein E · apolipoprotein M · beta2 glycoprotein 1 · clusterin · heparin · Apoa5 protein, mouse · apolipoprotein · Adenovirus · animal experiment · animal model · cholesterol blood level · conference paper · controlled study · disease association · female · gene overexpression · hypertriglyceridemia · in vivo study · lipoprotein deficiency · mouse · nonhuman · stimulation · triacylglycerol blood level · animal · blood · gene transfer · genetics · mouse mutant · physiology · Adenoviridae · Animals · Apolipoprotein C-III · Apolipoprotein E2 · Apolipoproteins · Gene Transfer Techniques · Hypertriglyceridemia · Lipids · Lipoprotein Lipase · Male · Mice · Mice, Knockout
[PDF] [Abstract]

9 Apolipoprotein CI inhibits scavenger receptor BI and increases plasma HDL levels in vivo
article 2008    
Author: Haan, W. de · Out, R. · Berbée, J.F.P. · Hoogt, C.C. van der · Dijk, K.W.v. · Berkel, T.J.C. van · Romijn, J.A. · Wouter Jukema, J. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Health · Physiological Sciences · High density lipoprotein · Oxidized LDL · SR-BI · Transgenic mice · cholesterol ester · high density lipoprotein cholesterol · scavenger receptor BI · Adenovirus · animal cell · cholesterol metabolism · dose response · in vivo study · liver cell · mouse · nonhuman · particle size · protein expression · Adenoviridae · Animals · Apolipoprotein C-I · Cholesterol, HDL · Gene Transfer Techniques · Hepatocytes · Humans · Mice · Mice, Knockout · Scavenger Receptors, Class B · Adenoviridae · Murinae · Mus · Mus musculus
[Abstract]

10 The hepatic uptake of VLDL in lrp-ldlr-/-vldlr-/- mice is regulated by LPL activity and involves proteoglycans and SR-BI
article 2008    
Author: Hu, L. · Hoogt, C.C. van der · Espirito Santo, S.M.S. · Out, R. · Kypreos, K.E. · Vlijmen, B.J.M. van · Berkel, T.J.C. van · Romijn, J.A. · Havekes, L.M. · Dijk, K.W. van · Rensen, P.C.N.
Keywords: Biology · Apolipoprotein · Denovirus-mediated gene transfer · Lipoprotein lipase · Low density lipoprotein receptor · Low density lipoprotein receptor-related protein · Transgenic mice · Triglyceride-rich emulsion particles · Very low density lipoprotein receptor · apolipoprotein E · cell surface protein · cholesterol · lipoprotein lipase · low density lipoprotein receptor · low density lipoprotein receptor related protein · proteoglycan · proteoheparan sulfate · scavenger receptor BI · triacylglycerol · very low density lipoprotein · very low density lipoprotein receptor · CD36 antigen · ligand · very low density lipoprotein cholesterol · Adenovirus · animal cell · animal experiment · animal tissue · article · cell isolation · cell surface · controlled study · enzyme activity · in vitro study · in vivo study · internalization · lipid analysis · liver cell · male · mouse · nonhuman · priority journal · protein expression · regulatory mechanism · animal · blood · emulsion · genetics · liver · metabolism · mouse mutant · Animals · Antigens, CD36 · Cholesterol, VLDL · Emulsions · LDL-Receptor Related Proteins · Ligands · Lipoprotein Lipase · Liver · Male · Mice · Mice, Knockout · Proteoglycans · Receptors, LDL · Healthy for Life · Healthy Living
[Abstract]

11 Torcetrapib does not reduce atherosclerosis beyond atorvastatin and induces more proinflammatory lesions than atorvastatin
article 2008    
Author: Haan, W. de · Vries-van der Weij, J. de · Hoorn, J.W.A. van der · Gautier, T. · Hoogt, C.C. van der · Westerterp, M. · Romijn, J.A. · Jukema, J.W. · Havekes, L.M. · Princen, H.M.G. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · Atherosclerosis · Cholesteryl ester transfer proteins · Drugs · Lipids · Lipoproteins · Apolipoprotein E · Atorvastatin · Cholesterol · Cholesterol ester transfer protein · Collagen · High density lipoprotein cholesterol · Monocyte chemotactic protein 1 · Torcetrapib · Atherosclerosis · Cholesterol blood level · Drug activity · Evaluation · Female · Inflammation · Macrophage · Monocyte · Mouse · Nonhuman · Phenotype · Sham feeding · Statistical significance · Animals · Atherosclerosis · Cholesterol Ester Transfer Proteins · Drug Synergism · Heptanoic Acids · Inflammation · Mice · Mice, Inbred Strains · Pyrroles · Quinolines
[PDF] [Abstract]

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Showing 1 to 11 of 11 found. | Sort by date