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1 Active MMPs captured by alpha2Macroglobulin as a marker of disease activity in rheumatoid arthritis
article 2003    
Author: Tchetverikov, I. · Verzijl, N. · Huizinga, T.W.J. · TeKoppele, J.M. · Hanemaaijer, R. · Groot, J. de
Keywords: Biology · Biomedical Research · α2Macroglobulin · Matrix metalloproteases · Rheumatoid arthritis · alpha 2 macroglobulin · batimastat · collagenase 3 · matrix metalloproteinase · tissue inhibitor of metalloproteinase 1 · article · circulation · clinical article · complex formation · concentration (parameters) · controlled study · correlation analysis · disease activity · disease course · disease marker · enzyme linked immunosorbent assay · erythrocyte sedimentation rate · fast protein liquid chromatography · fluorescence analysis · human · molecular weight · priority journal · protein analysis · protein blood level · quantitative analysis · rheumatoid arthritis · Adult · alpha-Macroglobulins · Arthritis, Rheumatoid · Biological Markers · Case-Control Studies · Disease Progression · Enzyme-Linked Immunosorbent Assay · Female · Humans · Male · Matrix Metalloproteinases · Middle Aged · Probability · Prognosis · Reference Values · Sensitivity and Specificity · Severity of Illness Index
[PDF] [Abstract]

2 Leflunomide and methotrexate reduce levels of activated matrix metalloproteinases in complexes with α2 macroglobulin in serum of rheumatoid arthritis patients
article 2008    
Author: Tchetverikov, I. · Kraan, M.C. · El, B. van · Hanemaaijer, R. · Groot, J. de · Huizinga, T.W.J.
Keywords: Biology · Biomedical Research · alpha 2 macroglobulin · C reactive protein · leflunomide · matrix metalloproteinase · methotrexate · teriflunomide · tissue inhibitor of metalloproteinase 1 · analysis · blood sampling · clinical study · complex formation · controlled study · disease activity · drug activity · drug dose increase · drug effect · drug efficacy · drug exposure · loading drug dose · major clinical study · priority journal · protein blood level · quantitative analysis · rheumatoid arthritis · serum · systemic circulation · Aged · alpha-Macroglobulins · Antirheumatic Agents · Arthritis, Rheumatoid · Biological Markers · C-Reactive Protein · Down-Regulation · Enzyme Inhibitors · Female · Humans · Isoxazoles · Male · Matrix Metalloproteinases · Methotrexate · Middle Aged · Multiprotein Complexes · Phenylalanine · Statistics, Nonparametric · Thiophenes
[Abstract]

3 RAGE activation induces invasiveness of RA fibroblast-like synoviocytes in vitro
article 2007    
Author: Steenvoorden, M.M.C. · Toes, R.E.M. · Ronday, H.K. · Huizinga, T.W.J. · Groot, J. de
Keywords: Biomedical Research · Fibroblast-like synoviocyte · HMGB-1 · Invasiveness · RAGE · Rheumatoid arthritis · advanced glycation end product · advanced glycation end product receptor · chemoattractant · glycosylated albumin · high mobility group B1 protein · ligand · matrigel · protein antibody · article · cell activation · cell function · cell invasion · controlled study · culture medium · fibroblast · human · human cell · in vitro study · joint prosthesis · priority journal · rheumatoid arthritis · serum · synovial fluid · synoviocyte · synovium · Antibodies, Anti-Idiotypic · Arthritis, Rheumatoid · Cell Movement · Cells, Cultured · Glycosylation End Products, Advanced · HMGB1 Protein · Humans · Receptors, Immunologic · Synovial Membrane
[Abstract]

4 MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis
article 2005    
Author: Tchetverikov, I. · Lohmander, L.S. · Verzijl, N. · Huizinga, T.W.J. · TeKoppele, J.M. · Hanemaaijer, R. · Groot, J. de
Keywords: Biomedical Research · alpha 2 macroglobulin · interstitial collagenase · matrix metalloproteinase · prointerstitial collagenase · prostromelysin · stromelysin · tissue inhibitor of metalloproteinase 3 · unclassified drug · arthritis · controlled study · enzyme activation · enzyme activity · enzyme inhibition · human · immunoassay · joint injury · knee · major clinical study · osteoarthritis · priority journal · protein determination · pseudogout · quantitative analysis · synovial fluid level · Acute Disease · Adult · alpha-Macroglobulins · Arthritis · Chondrocalcinosis · Cross-Sectional Studies · Female · Humans · Knee Injuries · Male · Matrix Metalloproteinases · Middle Aged · Osteoarthritis, Knee · Synovial Fluid · Tissue Inhibitor of Metalloproteinase-1
[Abstract]

5 Association between weight or body mass index and hand osteoarthritis: A systematic review
article 2010    
Author: Yusuf, E. · Nelissen, R.G. · Ioan-Facsinay, A. · Stojanovic-Susulic, V. · Groot, J. de · Osch, G. van · Middeldorp, S. · Huizinga, T.W.J. · Kloppenburg, M.
Keywords: Health · Biomedical Research
[Abstract]

6 Fibroblast-like synoviocyte-chondrocyte interaction in cartilage degradation
article 2007    
Author: Steenvoorden, M.M.C. · Bank, R.A. · Ronday, H.K. · Toes, R.E.M. · Huizinga, T.W.J. · Groot, J. de
Keywords: Health · Biomedical Research · Alginate recovered chondrocytes · Cartilage · Cartilage degradation · Fibroblast-like synoviocytes · In vitro model · Rheumatoid arthritis · Alginates · Animals · Arthritis, Rheumatoid · Cartilage · Cattle · Cell Communication · Cells, Cultured · Chondrocytes · Collagen · Disease Models, Animal · Fibroblasts · Glucuronic Acid · Hexuronic Acids · Interleukin-1beta · Osteoarthritis · Proteoglycans · Synovial Membrane · Tumor Necrosis Factor-alpha
[Abstract]

7 Elevated formation of pyridinoline cross-links by profibrotic cytokines is associated with enhanced lysyl hydroxylase 2b levels
article 2005    
Author: Slot, A.J. van der · Dura, E.A. van · Wit, E.C. de · Groot, J. de · Huizinga, T.W.J. · Bank, R.A. · Zuurmond, A.M.
Keywords: Lysyl hydroxylase 2b · Pyridinoline · TGF-β · Activin A · Protein lysine 6 oxidase · Transforming growth factor beta · Tumor necrosis factor alpha · Controlled study · Cross linking · Human cell · Protein expression · Skin fibroblast · Skin fibrosis · Upregulation · Activins · Amino Acids · Cells, Cultured · Collagen Type I · Cross-Linking Reagents · Cytokines · Fibroblasts · Fibrosis · Gene Expression Regulation, Enzymologic · Humans · Inhibin-beta Subunits · Interleukin-4 · Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase · Protein Isoforms · RNA, Messenger · Skin · Time Factors · Transforming Growth Factor beta · Tumor Necrosis Factor-alpha · Up-Regulation
[Abstract]

8 Matrix metalloproteinases-3, -8, -9 as markers of disease activity and joint damage progression in early rheumatoid arthritis
article 2003    
Author: Tchetverikov, I. · Lard, L.R. · Groot, J. de · Verzijl, N. · TeKoppele, J.M. · Breedveld, F.C. · Huizinga, T.W.J. · Hanemaaijer, R.
Keywords: Biology · Biomedical Research · gelatinase B · neutrophil collagenase · stromelysin · aged · arthropathy · disease activity · disease course · disease marker · enzyme activity · enzyme blood level · enzyme linked immunosorbent assay · female · human · joint destruction · longitudinal study · major clinical study · male · prediction · rheumatoid arthritis · Adult · alpha-Macroglobulins · Arthritis, Rheumatoid · Biological Markers · C-Reactive Protein · Disease Progression · Female · Humans · Joints · Male · Matrix Metalloproteinase 3 · Matrix Metalloproteinase 9 · Matrix Metalloproteinases · Middle Aged · Prospective Studies · Statistics, Nonparametric
[Abstract]

9 MMP profile in paired serum and synovial fluid samples of patients with rheumatoid arthritis
article 2004    
Author: Tchetverikov, I. · Ronday, H.K. · El, B. van · Kiers, G.H. · Verzijl, N. · TeKoppele, J.M. · Huizinga, T.W.J. · Groot, J. de · Hanemaaijer, R.
Keywords: alpha 2 macroglobulin · biological marker · gelatinase A · gelatinase B · hydroxyproline · interstitial collagenase · matrix metalloproteinase · neutrophil collagenase · stromelysin · tissue inhibitor of metalloproteinase 1 · aged · circulation · clinical article · collagen degradation · concentration (parameters) · controlled study · correlation analysis · enzyme activity · enzyme assay · enzyme linked immunosorbent assay · female · high performance liquid chromatography · human · male · osteoarthritis · priority journal · rheumatoid arthritis · sampling · serum · statistical significance · synovial fluid · Adult · Aged · alpha-Macroglobulins · Arthritis, Rheumatoid · Case-Control Studies · Collagenases · Enzyme Precursors · Enzyme-Linked Immunosorbent Assay · Female · Humans · Hydroxyproline · Male · Matrix Metalloproteinase 8 · Matrix Metalloproteinase 9 · Matrix Metalloproteinases · Metalloendopeptidases · Middle Aged · Osteoarthritis, Knee · Statistics, Nonparametric · Synovial Fluid · Tissue Inhibitor of Metalloproteinase-1
[Abstract]

10 Profiling the Secretion of Soluble Mediators by End Stage Osteoarthritis Synovial Tissue Explants Reveals a Reduced Responsiveness to an Inflammatory Trigger
article 2013    
Author: Gierman, L.M. · El, B. van · Ham, F. van der · Koudijs, A. · Stoop, R. · Verheijen, J.H. · Kloppenburg, M. · Osch, G.J.V.M. van · Stojanovic-Susulic, V. · Huizinga, T.W.J. · Zuurmond, A.-M.
Keywords: Biology · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

11 Metabolic Stress–Induced Inflammation Plays a Major Role in the Development of Osteoarthritis in Mice
article 2012    
Author: Gierman, L.M. · Ham, F. van der · Koudijs, A. · Wielinga, P.Y. · Kleemann, R. · Kooistra, T. · Stoop, R. · Kloppenburg, M. · Osch, G.J.V.M. van · Stojanovic-Susulic, V. · Huizinga, T.W. · Zuurmond, A.M.
Keywords: Biology · Healthy for Life · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences

12 Metabolic profiling reveals differences in concentrations of oxylipins and fatty acids secreted by the infrapatellar fat pad of donors with end-stage osteoarthritis and normal donors
article 2013    
Author: Gierman, L.M. · Wopereis, S. · El, B. van · Verheij, E.R. · Werff-Van Der Vat, B.J.C. · Bastiaansen-Jenniskens, Y.M. · Osch, G.J.V.M. van · Kloppenburg, M. · Stojanovic-Susulic, V. · Huizinga, T.W.J. · Zuurmond, A.M.
Keywords: Biology · Food and Nutrition · Healthy Living · Life · MHR - Metabolic Health Research MSB - Microbiology and Systems Biology RAPID - Risk Analysis for Products in Development · EELS - Earth, Environmental and Life Sciences
[Abstract]

13 An explorative study comparing levels of soluble mediators in control and osteoarthritic synovial fluid
article 2013    
Author: Beekhuizen, M. · Gierman, L.M. · Spil, W.E. van · Osch, G.J.V.M. van · Huizinga, T.W.J. · Saris, D.B.F. · Creemers, L.B. · Zuurmond, A.-M.
Keywords: Biology · Chemokines · Cytokines · Growth factors · Synovial fluid · Food and Nutrition · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

14 Synovial inflammation, immune cells and their cytokines in osteoarthritis: A review
article 2012    
Author: Lange-Brokaar, B.J.E. de · Ioan-Facsinay, A. · Osch, G.J.V.M. van · Zuurmond, A.-M. · Schoones, J. · Toes, R.E.M. · Huizinga, T.W.J. · Kloppenburg, M.
Keywords: Cytokines · Histology · Immune cells · Inflammation · Osteoarthritis · Synovial tissue · gamma interferon · interleukin 10 · interleukin 18 · interleukin 1beta · interleukin 2 · interleukin 4 · interleukin 6 · interleukin 8 · transforming growth factor beta · tumor necrosis factor alpha · cell infiltration · cytokine release · hip arthroplasty · immunocompetent cell · immunohistochemistry · information retrieval · knee arthroscopy · macrophage · mast cell · needle biopsy · osteoarthritis · priority journal · review · rheumatoid arthritis · synovectomy · synovitis · T lymphocyte · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

15 Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE*3Leiden.CETP mice, a translational model for atherosclerosis
article 2014    
Author: Gierman, L.M. · Kühnast, S. · Koudijs, A. · Pieterman, E.J. · Kloppenburg, M. · Osch, G.J.V.M. van · Stojanovic-Susulic, V. · Huizinga, T.W.J. · Princen, H.M.G. · Zuurmond. A.M.
Keywords: Biology · Alanine aminotransferase · Apolipoprotein E · Atorvastatin · Cholesterol ester transfer protein · Endothelial leukocyte adhesion molecule 1 · Etimibe · Monocyte chemotactic protein 1 · Serum amyloid A · Very low density lipoprotein · Animal experiment · Animal model · Animal tissue · Atherosclerosis · Cholesterol blood level · Cholesterol intake · Controlled study · Female · Knee osteoarthritis · Mouse · Nonhuman · Priority journal · Transgenic mouse · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

16 Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of a cell surface-targeted plasmin inhibitor
article 2000    
Author: Laan, W.H. van der · Pap, T. · Ronday, H.K. · Grimbergen, J.M. · Huisman, L.G.M. · TeKoppele, J.M. · Breedveld, F.C. · Gay, R.E. · Gay, S. · Huizinga, T.W.J. · Verheijen, J.H. · Quax, P.H.A.
Keywords: Health · Biomedical Research

17 Degradation of a cartilage-like matrix by rheumatoid synovial fibroblasts is inhibited by gene transfer with a cell surface-targeted plasmin inhibitor: abstract
article 1999    
Author: Laan, W.H. van der · Ronday, H.K. · Grimbergen, J.M. · Huisman, L.G.M. · Breedveld, F.C. · Koppele, J.M. te · Huizinga, T.W.J. · Quax, P.H.A. · Verheijen, J.H.
Keywords: Biomedical Research
[PDF]

18 Cartilage invasion by rheumatoid synovial fibroblasts in vivo is inhibited by gene transfer of a cell surface-targeted plasmin inhibitor: abstract
article 2000    
Author: Laan, W.H. van der · Ronday, H.K. · Grimbergen, J.M. · Huisman, L.G.M. · TeKoppele, J.M. · Breedveld, F.C. · Gay, R.E. · Gay, S. · Huizinga,T.W.J. · Verheijen, J.H. · Quax, P.H.A. · Pap, T.
Keywords: Biomedical Research

19 Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of TIMP-1 and TIMP-3
article 2003    
Author: Laan, W.H. van der · Quax, P.H.A. · Seemayer, C.A. · Huisman, L.G.M. · Pieterman, E.J. · Grimbergen, J.M. · Verheijen, J.H. · Breedveld, F.C. · Gay, R.E. · Gay, S. · Huizinga, T.W.J. · Pap, T.
Keywords: Adenoviridae · Animals · Arthritis, Rheumatoid · Cartilage, Articular · Cell Division · Fibroblasts · Gene Expression · Gene Therapy · Genetic Vectors · Humans · Matrix Metalloproteinases · Mice · Mice, SCID · Synovial Membrane · Tissue Inhibitor of Metalloproteinase-1 · Tissue Inhibitor of Metalloproteinase-3 · Transduction, Genetic · Adenoviridae · Animalia
[Abstract]

20 Afbraak van kraakbeenmatrix door rheumatoïde synoviocyten wordt geremd door een membraan gebonden plasmine remmer via gentherapie
bookPart 1999    
Author: Laan, W.H. van der · Ronday, H.K. · Grimbergen, J.M. · Huisman, L.G.M. · TeKoppele, J.M. · Huizinga, T.W.J. · Breedveld, F.C. · Verheijen, J.H. · Quax, P.H.A.
Keywords: Health · Biomedical Research

Search results also available in MS Excel format.

Showing 1 to 20 of 25 found. Next | Sort by date