Repository hosted by TU Delft Library

Home · Contact · About · Disclaimer ·
 

Search results also available in MS Excel format.

Showing 1 to 5 of 5 found. | Sort by date

1 Basil extract inhibits the sulfotransferase mediated formation of DNA adducts of the procarcinogen 1′-hydroxyestragole by rat and human liver S9 homogenates and in HepG2 human hepatoma cells
article 2008    
Author: Jeurissen, S.M.F. · Punt, A. · Delatour, T. · Rietjens, I.M.C.M.
Keywords: Alkenylbenzenes · DNA adducts · Estragole · Ocimum basilicum · Sulfotransferases · 1' hydroxyestragole · Animals · Anisoles · Biotransformation · Carcinoma, Hepatocellular · Cell Line, Tumor · Cell Survival · Chromatography, High Pressure Liquid · Deoxyguanosine · DNA Adducts · DNA Repair · Enzyme Inhibitors · Humans · Liver · Liver Neoplasms · Ocimum basilicum · Plant Extracts · Rats · Risk Assessment · Spectrometry, Mass, Electrospray Ionization · Subcellular Fractions · Sulfotransferases · Tetrazolium Salts · Thiazoles · Ocimum · Ocimum basilicum · Rattus
[Abstract]

2 Human cytochrome P450 enzyme specificity for the bioactivation of estragole and related alkenylbenzenes
article 2007    
Author: Jeurissen, S.M.F. · Punt, A. · Boersma, M.G. · Bogaards, J.J.P. · Fiamegos, Y.C. · Schilter, B. · Bladeren, P.J. van · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · 1' hydroxyestragole · alkenylbenzene derivative · alpha naphthoflavone · benzene derivative · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2C19 · cytochrome P450 2D6 · cytochrome P450 2E1 · estragole · methyleugenol · safrole · article · enzyme specificity · human · human cell · hydroxylation · liver microsome · phenotype · protein expression · Anisoles · Biotransformation · Chromatography, High Pressure Liquid · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Eugenol · Flavoring Agents · Humans · Hydroxylation · Microsomes, Liver · Safrole · Substrate Specificity
[Abstract]

3 Development of an on-line high performance liquid chromatography detection system for human cytochrome P450 1A2 inhibitors in extracts of natural products
article 2007    
Author: Jeurissen, S.M.F. · Claassen, F.W. · Havlik, J. · Bouwmans, E.E. · Cnubben, N.H.P. · Sudhölter, E.J.R. · Rietjens, I.M.C.M. · Beek, T.A. van
Keywords: Biomedical Research · Methoxyresorufin-O-demethylase · Mixture analysis · On-line detection · P450 1A2 inhibitors · Bioassay · Cytology · Enzyme inhibition · Fluorescence · Metabolites · Screening · Methoxyresorufin-O-demethylase · Mixture analysis · On-line detection · P450 1A2 inhibitors · High performance liquid chromatography · basil extract · cytochrome P450 1A2 · cytochrome P450 1A2 inhibitor · cytochrome P450 inhibitor · fluvoxamine · furafylline · kava extract · methoxyresorufin · naringenin · natural product · plant extract · propranolol · resorufin · resorufin derivative · tacrine · article · assay · basil · demethylation · fluorescence · high performance liquid chromatography · metabolite · methoxyresorufin O demethylation assay · minimum detectable amount · online analysis · parameter · priority journal · screening · Biological Products · Chromatography, High Pressure Liquid · Cytochrome P-450 CYP1A2 · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Humans · Inhibitory Concentration 50 · Kava · Methanol · Ocimum basilicum · Online Systems · Oxidoreductases · Plant Extracts · Spectrometry, Fluorescence · Spectrophotometry, Ultraviolet · Ocimum basilicum · Piper methysticum
[Abstract]

4 Human cytochrome P450 enzyme specificity for bioactivation of safrole to the proximate carcinogen 1′-hydroxysafrole
article 2004    
Author: Jeurissen, S.M.F. · Bogaards, J.J.P. · Awad, H.M. · Boersma, M.G. · Brand, W. · Fiamegos, Y.C. · Beek, T.A. van · Alink, G.M. · Sudhölter, E.J.R. · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Physiological Sciences · 1' hydroxysafrole · carcinogen · cytochrome P450 · cytochrome P450 2A6 · cytochrome P450 2C9 · cytochrome P450 2D6 · cytochrome P450 2E1 · safrole · unclassified drug · animal cell · article · enzyme activation · enzyme specificity · human · insect cell · microsome · nonhuman · reaction analysis · Biotransformation · Carcinogens · Cytochrome P-450 Enzyme System · Humans · Microsomes, Liver · Risk Assessment · Safrole · Statistics, Nonparametric · Substrate Specificity · Animalia · Insecta
[Abstract]

5 Human cytochrome P450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1′-hydroxymethyleugenol
article 2006    
Author: Jeurissen, S.M.F. · Bogaards, J.J.P. · Boersma, M.G. · Horst, J.P.F. ter · Awad, H.M. · Fiamegos, Y.C. · Beek, T.A. van · Alink, G.M. · Sudhölter, E.J.R. · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · 1' hydroxymethyleugenol · barbituric acid derivative · carcinogen · cytochrome P450 · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2C19 · cytochrome P450 2C9 · cytochrome P450 2D6 · methyleugenol · unclassified drug · article · carcinogenicity · concentration (parameters) · enzyme activation · enzyme kinetics · enzyme specificity · enzyme substrate · human · hydroxylation · incubation time · insect cell · lifestyle · liver microsome · nonhuman · sensitivity analysis · smoking · Aryl Hydrocarbon Hydroxylases · Benzoflavones · Biotransformation · Carcinogens · Cell Line · Cytochrome P-450 CYP1A2 · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Eugenol · Flavoring Agents · Humans · Kinetics · Microsomes, Liver · Mixed Function Oxygenases · Recombinant Proteins · Risk Assessment · Sulfaphenazole · Insecta
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 5 of 5 found. | Sort by date